New GDA Ingredient - Ficus lutea

Grayson

Grayson

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Source: http://science-project.ru/imedia/4440292381332791_manuscript.pdf

The potential role of GLUT4 transporters and insulin receptors in the hypoglycaemic activity
of Ficus lutea acetone leaf extract.
Abstract
Background: Some Ficus species have been used in traditional African medicine in the
treatment of diabetes. The antidiabetic potential of certain species has been confirmed in vivo
but the mechanism of activity remains uncertain.
The aim was to investigate the hypoglycaemic potential of ten Ficus species focussing on
glucose uptake, insulin secretion and the possible mechanism of hypoglycaemic activity.
Methods: The dried and ground leaves of ten Ficus species were extracted with acetone. The
dried acetone extract was reconstituted with DMSO to a concentration of 100 mg/ml which
was then serially diluted and used to assay for glucose uptake in muscle, fat and liver cells,
and insulin secretion in pancreatic cells.
Results: Only the F. lutea extract was able to modulate glucose metabolism. In comparison to
insulin in the primary muscle cells, the glucose uptake ability of the extract was 33% as
effective. In the hepatoma cell line, the extract was as effective as metformin in decreasing extracellular glucose concentration by approximately 20%. In the pancreatic insulin secretory
assay, the extract was 4 times greater in its secretory activity than commercial glibenclamide.
With F. lutea extract significantly increasing glucose uptake in the primary muscle cells,
primary fat cells, C2C12 muscle and H-4-II-E liver cells, the extract may act by increasing
the activity of cell surface glucose transporters. When the 3T3-L1 pre-adipocytes were
compared to the primary muscle, primary fat and C2C12 cells, the differences in the former’s
ability to transport glucose into the cell is due to the absence of the GLUT4 transporter, which
on activation via the insulin receptor decreases extracellular glucose concentrations. Because
the pre-adipocytes failed to show any active increase in glucose uptake, the present effect has
to be linked to the absence of the GLUT4 transporter.

Conclusion: Only F. lutea possessed substantial in vitro activity related to glucose
metabolism. Based on the effect produced in the various cell types, F. lutea also appears to be
a partial agonist/antagonist of the insulin cell membrane receptor. While the clinical
effectiveness of F. lutea is not known, this plant species does possess the ability to modify
glucose metabolism.
 

De__eB

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Someone may or may not end up selling it based on this but it would really be folly without some effectiveness data, when we already have numerous other compounds working along the same MOA on the market today.
 
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Grayson

Grayson

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Someone may or may not end up selling it based on this but it would really be folly without some effectiveness data, when we already have numerous other compounds working along the same MOA on the market today.
I agree with your statement. We need in vitro data before making assumptions, but this initial data does look promising.
 
warbird01

warbird01

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Someone may or may not end up selling it based on this but it would really be folly without some effectiveness data, when we already have numerous other compounds working along the same MOA on the market today.
I am already capping this in my bathtub, shhh
 
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