I would usually only get them in my calves a little during cardio if I wasn't staying hydrated enough or taking in enough sodium. One time though, I was food shopping and when it came time to load up the car I started feeling really sore. I thought it was workout soreness but when I got home everything started to lock up, I started downing water and electrolytes and was fine after like an hour. That was my fault though, barely hydrated myself in fear of having to hit the pisser a million times at the store.
Now I stick at 1 gram per day divided morning and night instead of pushing it towards 2 grams. Also, if I know I won't be able to drink for a while (I teach and you can't leave your classroom to piss lol) then I will just push back the dose and make it work for my schedule.