Muscle Specific GDA

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  1. Muscle Specific GDA


    Are there any?

    From all the research and threads I've encountered, not once have I read that a glucose disposal agent ingredient would be muscle specific.

    If anything, can we suppose that the most we'd want to accomplish before a cheat meal/heavy carb load would be reduced blood sugar?


  2. TUDCA may be.

    Not at an economically feasible dosage, though.
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  3. You also need to differentiate between products that have GDA properties and ones that promote insulin sensitivity.
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  4. Quote Originally Posted by aaronuconn View Post
    You also need to differentiate between products that have GDA properties and ones that promote insulin sensitivity.
    For a body recomp position, we don't want total enhanced insulin sensitivity due to insulin acting on both muscle and fat cells.

    We also do not want enhanced glut-4 expression because glut-4 is located in skeletal muscle and adipose tissue.

    Thus to get the most out of carbs, instead of the aforementioned, and instead of delaying/preventing glucose absorbtion (GCB or gymnema), how can we create an optimal situation for shuttling glucose into skeletal muscle without affecting fat? (besides working out)

  5. Quote Originally Posted by The Engineer View Post
    For a body recomp position, we don't want total enhanced insulin sensitivity due to insulin acting on both muscle and fat cells. We also do not want enhanced glut-4 expression because glut-4 is located in skeletal muscle and adipose tissue. Thus to get the most out of carbs, instead of the aforementioned, and instead of delaying/preventing glucose absorbtion (GCB or gymnema), how can we create an optimal situation for shuttling glucose into skeletal muscle without affecting fat? (besides working out)
    Correct, I was referring to muscle insulin sensitivity as opposed to adipose insulin sensitivity.

    There aren't many compounds that I can think if that take preference for muscle.
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  6. Isn't berberine?

  7. Quote Originally Posted by xhrr View Post
    Isn't berberine?
    I would say so…..

  8. Quote Originally Posted by xhrr View Post
    Isn't berberine?
    This. Berberine is unique in that it activates Glut4 but also blocks PPAR gamma, thus making it tissue specific to muscle tissue.
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  9. Squats!

    I am also a fan of berberine
    "The only good is knowledge and the only evil is ignorance." - Socrates

  10. Quote Originally Posted by Myokemist View Post
    This. Berberine is unique in that it activates Glut4 but also blocks PPAR gamma, thus making it tissue specific to muscle tissue.
    May I have a source please?

  11. Quote Originally Posted by The Engineer View Post
    May I have a source please?
    http://www.ncbi.nlm.nih.gov/pubmed/16890192

  12. Thanks. But, what about atrogin-1 and suppressing muscle hypertrophy?

    Working would theoretically blunt this, but still there are no guarantees.

  13. Quote Originally Posted by The Engineer View Post
    May I have a source please?
    This shows inhibition of PPAR gamma:
    http://www.ncbi.nlm.nih.gov/m/pubmed/19767038/

    PPAR gamma agonists activate GLUT4 translocation. PPAR gamma is present primarily in adipocytes. So by inhibiting PPAR gamma, berberine will not cause GLUT4 translocation in adipocytes.

    Hope this helps.
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  14. "The only good is knowledge and the only evil is ignorance." - Socrates

  15. Quote Originally Posted by The Engineer View Post
    Thanks. But, what about atrogin-1 and suppressing muscle hypertrophy? Working would theoretically blunt this, but still there are no guarantees.
    I'd think anything increasing AMPk would be considered something "suppressing hypertrophy", how to an appreciable amount? Doubt it.
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  16. Quote Originally Posted by aaronuconn View Post
    I'd think anything increasing AMPk would be considered something "suppressing hypertrophy", how to an appreciable amount? Doubt it.
    Anecdotally I have never noticed it. By far one of my favorite ingredients regardless of goals.

  17. Good thread, Ive actually noticed that I gain fat easier with some GDA products. With that in mind, Recompadrol is my go-to now, dont even bother with those that actually slow my progress.
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  18. Quote Originally Posted by SwolenONE View Post
    Good thread, Ive actually noticed that I gain fat easier with some GDA products. With that in mind, Recompadrol is my go-to now, dont even bother with those that actually slow my progress.
    Recompadrol is my go-to GDA too along with NA-RALA

  19. Quote Originally Posted by cbsharpe View Post
    Recompadrol is my go-to GDA too along with NA-RALA
    Amen
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  20. Quote Originally Posted by The Engineer View Post
    Thanks. But, what about atrogin-1 and suppressing muscle hypertrophy?

    Working would theoretically blunt this, but still there are no guarantees.
    EFB has addressed this in a thread before stating that the amount of suppression is negligible, regardless the glut4 activation greatly outweighs the amount of suppression

  21. Yellow Gold is pure berberine I believe but its out of stock atm

    NutraPlanet Yellow Gold (150 grams): Discount Yellow Gold Supplements
    phaggy opinions+certainty=douchebag status

  22. Actually 50 gram bottle is in stock http://www.nutraplanet.com/product/n...-50-grams.html
    phaggy opinions+certainty=douchebag status

  23. Quote Originally Posted by Quadzilla99 View Post
    Yellow Gold is pure berberine I believe but its out of stock atm NutraPlanet Yellow Gold (150 grams): Discount Yellow Gold Supplements
    Do you typically cap this yourself or take as powder?
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  24. Quote Originally Posted by aaronuconn View Post
    Do you typically cap this yourself or take as powder?
    I've heard its nearly deadly as far as taste goes ha.
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  25. Quote Originally Posted by aaronuconn View Post
    Do you typically cap this yourself or take as powder?
    I haven't tried it yet. I bought a bottle and am planning to start taking it this week. Heard it tastes awful might wrap it up in something digestible and swallow it that way if it tastes too horrid
    phaggy opinions+certainty=douchebag status

  26. I can assure you that you DO NOT want to just throw it in the mouth and chase it with water. It is by far the worst tasting supplement/thing you will ever try. I would at least parachute it.

    Or try it, video it, and let us watch haha.
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  27. Quote Originally Posted by kbayne View Post
    I can assure you that you DO NOT want to just throw it in the mouth and chase it with water. It is by far the worst tasting supplement/thing you will ever try. I would at least parachute it. Or try it, video it, and let us watch haha.
    Please do! LOL
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  28. Quote Originally Posted by kbayne View Post
    I can assure you that you DO NOT want to just throw it in the mouth and chase it with water. It is by far the worst tasting supplement/thing you will ever try. I would at least parachute it.

    Or try it, video it, and let us watch haha.
    I've chugged it and gotten used to it. Cissus is much more tolerable than berberine though. However it stains everything horribly.
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  29. Quote Originally Posted by Adobo View Post
    I've chugged it and gotten used to it. Cissus is much more tolerable than berberine though. However it stains everything horribly.
    I went through a 50 gram bottle and never got used to it lol. I did the parachute method whenever I could.
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  30. What about playing around with turmeric?

    http://www.ergo-log.com/turmericglucose.html

    Increased glycogen = fuller muscles. This looks like you can increase muscle glycogen while burning fat through AMPK.

  31. Quote Originally Posted by The Engineer View Post
    What about playing around with turmeric?

    http://www.ergo-log.com/turmericglucose.html

    Increased glycogen = fuller muscles. This looks like you can increase muscle glycogen while burning fat through AMPK.
    Has bioavailability problems. I got some meriva phytosomal curcumin on a sale which is supposed to be the best kind and I still don't think it worked
    phaggy opinions+certainty=douchebag status

  32. Quote Originally Posted by Quadzilla99 View Post
    Has bioavailability problems. I got some meriva phytosomal curcumin on a sale which is supposed to be the best kind and I still don't think it worked
    I remember discussing this with you before, but is Mervia still considered number 1? What were some of the other options?
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  33. Quote Originally Posted by Quadzilla99 View Post
    Has bioavailability problems. I got some meriva phytosomal curcumin on a sale which is supposed to be the best kind and I still don't think it worked
    From what I've read, bioperine greatly increases bioavailabiliy.
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  34. Berberine uncapped worse than cissus lol. No thanks.

  35. Quote Originally Posted by aaronuconn View Post
    I remember discussing this with you before, but is Mervia still considered number 1? What were some of the other options?
    I think the meriva is still supposed to be the best. I tried two big bottles (Source Naturals brand) and stopped caring when that did nothing perceivable for me so I dunno if anythings changed
    phaggy opinions+certainty=douchebag status

  36. The way I can describe the taste of yellow gold is burnt rubber. If you have ever smelled that smell after someone burned rubber, just imagine what it would taste like. Nothing can cover up that taste.
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  37. Quote Originally Posted by T-Bone View Post
    The way I can describe the taste of yellow gold is burnt rubber. If you have ever smelled that smell after someone burned rubber, just imagine what it would taste like. Nothing can cover up that taste.
    Yep it is horrible. I can tolerate bulk cissus powder by chugging it in a little bit of water but Berberine is way worse so if you can't handle cissus don't even bother trying bulk berberine. Cissus is nice in that it doesn't linger like berberine. Berberine will hang around for an hour or so after it's that bad. I didn't believe it at first so I tried it myself and all accounts are true. I capped 100 grams before which is a pain in the ass but some powder still gets on the side of the caps so when I take it I get a little bit of that delicious residue. I would just stick to a good GDA that includes berberine unless you have time to cap the bulk powder. Burn 24 is the best imo followed by Recompadrol. They work better than straight berberine in my exp,. anyway but I would never use a GDA that didn't include it as I think it is the all star of any good formulation.

  38. Quote Originally Posted by aaronuconn View Post
    I'd think anything increasing AMPk would be considered something "suppressing hypertrophy", how to an appreciable amount? Doubt it.
    lifting weights increases AMPK

  39. also Anabolic Pump (AP) is the only GDA shown to work acutely in healthy males that exercise.

  40. Quote Originally Posted by USPlabsRep View Post
    also Anabolic Pump (AP) is the only GDA shown to work acutely in healthy males that exercise.
    Yet to try AP still. Not sure why I haven't gave it a go yet.
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