inb4 inside future PES product.
GDA, b2 agonist, sleep aid, anxiolytic activity, NO Booster, Improved memory and learning,
Saffron has been widely used throughout the world due to its innumerable effect on the human body as a spice and as a folk medicine, to treat the nervous system (insomnia, paralysis), the respiratory system (asthma, colds), the cardiovascular system (heart disease), the digestive system (stomach disorders, flatulence, colic, and ailments such as scarlet fever, smallpox, gout, and eye disease. It has been also used as an aphrodisiac, antispasmodic, and expectorant . Modern pharmacological studies have demonstrated Crocus sativus or its active constituents to have anti-inflammatory, antioxidant, hypolipidemic insulin-resistance reducing , and hypoglycemic effects.
GDA - Saffron (Crocus sativus L.) increases glucose upta... [Food Chem. 2012] - PubMed - NCBI
Appetite suppressant - Satiereal, a Crocus sativus L extract, reduces snac... [Nutr Res. 2010] - PubMed - NCBI
Erectile dysfunction
- Evaluation of Crocus sativus L. (saffron) on m... [Phytomedicine. 2009] - PubMed - NCBI
- Effect of saffron on fluoxetine-in... [Psychopharmacology (Berl). 2012] - PubMed - NCBI
Relaxant property
To study the mechanism(s) of the relaxant effects of C. sativus (Iridaceae), the stimulatory effect of aqueous-ethanolic extracts of this plant and one of its constituent, safranal, was examined on β-adrenoreceptors in tracheal chains of guinea pigs. The β2-adrenergic stimulatory was tested by performing the cumulative concentration-response curves of isoprenaline-induced relaxation of pre-contracted isolated guinea pig tracheal chains. The studied solutions included two concentrations of aqueous ethanolic extracts from C. sativus (0.1 and 0.2 g%), safranal (1.25 and 2.5 μg), 10 nM propranalol, and saline. The study was done in two different conditions including non-incubated (group 1, n = 9) and incubated tissues with 1 μM chlorpheniramine (group 2, n = 6). The results showed clear leftward shifts in isoprenaline curves obtained in the presence of only higher concentration of the extract in group 1 and its both concentrations in group 2 compared with that of saline. The EC50 (the effective concentration of isoprenaline, causing 50% of maximum response) obtained in the presence of both concentrations of the extract (0.17 ± 0.06 and 0.12 ± 0.02) and safranal (0.22 ± 0.05 and 0.22 ± 0.05) in group 1 and only in the presence of two concentrations of the extract (1.16 ± 0.31 and 0.68 ± 0.21) in group two was significantly lower compared to saline. The maximum responses obtained in the presence of both concentrations of the extract and safranal in group 1 were significantly lower than that of saline. The results indicated a relatively potent stimulatory effect of the extract from C. sativus on β2-adrenoreceptors, which is partially due to its constituent, safranal. A possible inhibitory effect of the plant on histamine (H1) receptors was also suggested
in addition, in a recent pre-clinical study, it has been reported that petal of C. sativus, the part of this herb that is very cheap compared to stigma of C. sativus (saffron), has antidepressant effect.
The saffron extract and two of its main ingredients, crocin and crocetin, improved memory and learning skills in ethanol-induced learning behavior impairments in mice and rats. Oral administration of saffron may be useful in the treatment of neurodegenerative disorders and related memory impairment.
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Crocin analogs isolated from saffron significantly increased the blood flow in the retina and choroid as well as facilitated retinal function recovery and it could be used to treat ischemic retinopathy and/or age-related macular degeneration.
something interesting
New insights into the biological properties o... [Eur J Med Chem. 2014] - PubMed - NCBI
-
Crocus sativus L.: A comprehensive review
Crocus sativus - Epilepsy Naturapedia
New insights into the biological properties o... [Eur J Med Chem. 2014] - PubMed - NCBI
Nephrotoxicity and hepatotoxicity evaluation of Crocus sativus stigmas in neonates of nursing mice
Selective Th2 Upregulation by Crocus sativus: A Neutraceutical Spice
GDA, b2 agonist, sleep aid, anxiolytic activity, NO Booster, Improved memory and learning,
Saffron has been widely used throughout the world due to its innumerable effect on the human body as a spice and as a folk medicine, to treat the nervous system (insomnia, paralysis), the respiratory system (asthma, colds), the cardiovascular system (heart disease), the digestive system (stomach disorders, flatulence, colic, and ailments such as scarlet fever, smallpox, gout, and eye disease. It has been also used as an aphrodisiac, antispasmodic, and expectorant . Modern pharmacological studies have demonstrated Crocus sativus or its active constituents to have anti-inflammatory, antioxidant, hypolipidemic insulin-resistance reducing , and hypoglycemic effects.
GDA - Saffron (Crocus sativus L.) increases glucose upta... [Food Chem. 2012] - PubMed - NCBI
Appetite suppressant - Satiereal, a Crocus sativus L extract, reduces snac... [Nutr Res. 2010] - PubMed - NCBI
Erectile dysfunction
- Evaluation of Crocus sativus L. (saffron) on m... [Phytomedicine. 2009] - PubMed - NCBI
- Effect of saffron on fluoxetine-in... [Psychopharmacology (Berl). 2012] - PubMed - NCBI
Relaxant property
To study the mechanism(s) of the relaxant effects of C. sativus (Iridaceae), the stimulatory effect of aqueous-ethanolic extracts of this plant and one of its constituent, safranal, was examined on β-adrenoreceptors in tracheal chains of guinea pigs. The β2-adrenergic stimulatory was tested by performing the cumulative concentration-response curves of isoprenaline-induced relaxation of pre-contracted isolated guinea pig tracheal chains. The studied solutions included two concentrations of aqueous ethanolic extracts from C. sativus (0.1 and 0.2 g%), safranal (1.25 and 2.5 μg), 10 nM propranalol, and saline. The study was done in two different conditions including non-incubated (group 1, n = 9) and incubated tissues with 1 μM chlorpheniramine (group 2, n = 6). The results showed clear leftward shifts in isoprenaline curves obtained in the presence of only higher concentration of the extract in group 1 and its both concentrations in group 2 compared with that of saline. The EC50 (the effective concentration of isoprenaline, causing 50% of maximum response) obtained in the presence of both concentrations of the extract (0.17 ± 0.06 and 0.12 ± 0.02) and safranal (0.22 ± 0.05 and 0.22 ± 0.05) in group 1 and only in the presence of two concentrations of the extract (1.16 ± 0.31 and 0.68 ± 0.21) in group two was significantly lower compared to saline. The maximum responses obtained in the presence of both concentrations of the extract and safranal in group 1 were significantly lower than that of saline. The results indicated a relatively potent stimulatory effect of the extract from C. sativus on β2-adrenoreceptors, which is partially due to its constituent, safranal. A possible inhibitory effect of the plant on histamine (H1) receptors was also suggested
in addition, in a recent pre-clinical study, it has been reported that petal of C. sativus, the part of this herb that is very cheap compared to stigma of C. sativus (saffron), has antidepressant effect.
The saffron extract and two of its main ingredients, crocin and crocetin, improved memory and learning skills in ethanol-induced learning behavior impairments in mice and rats. Oral administration of saffron may be useful in the treatment of neurodegenerative disorders and related memory impairment.
-
Crocin analogs isolated from saffron significantly increased the blood flow in the retina and choroid as well as facilitated retinal function recovery and it could be used to treat ischemic retinopathy and/or age-related macular degeneration.
something interesting
New insights into the biological properties o... [Eur J Med Chem. 2014] - PubMed - NCBI
-
Crocus sativus L.: A comprehensive review
Crocus sativus - Epilepsy Naturapedia
New insights into the biological properties o... [Eur J Med Chem. 2014] - PubMed - NCBI
Nephrotoxicity and hepatotoxicity evaluation of Crocus sativus stigmas in neonates of nursing mice
Selective Th2 Upregulation by Crocus sativus: A Neutraceutical Spice