Berberine and Muscle Protein Synthesis

  1. Advanced Member
    GreenMachineX's Avatar
    Stats
    5'8"  232 lbs.
    Join Date
    Jan 2014
    Posts
    579
    Rep Power
    378483
    Level
    31
    Lv. Percent
    18.54%
    Achievements Activity Pro

    Berberine and Muscle Protein Synthesis


    Atrogin-1 affects muscle protein synthe - PubMed Mobile

    Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine.

    AuthorsWang H, et al. Show all Journal
    Diabetes. 2010 Aug;59(8):1879-89. doi: 10.2337/db10-0207. Epub 2010 Jun 3.

    CONCLUSIONS: Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy.

    PMID 20522589 [PubMed - indexed for MEDLINE]

    Looks like bad news for berberine. Anyone have any thoughts?

  2. Senior Member
    cbsharpe's Avatar
    Stats
    6'1"  225 lbs.
    Join Date
    Apr 2008
    Posts
    1,725
    Rep Power
    846833
    Level
    45
    Lv. Percent
    66.18%
    Achievements Activity ProPosting Pro

    Whoa....
  3. Advanced Member
    GreenMachineX's Avatar
    Stats
    5'8"  232 lbs.
    Join Date
    Jan 2014
    Posts
    579
    Rep Power
    378483
    Level
    31
    Lv. Percent
    18.54%
    Achievements Activity Pro

    Hopefully someone can dispel this as not applicable to humans...
    •   
       

  4. Board Sponsor
    Distilled Water's Avatar
    Stats
    5'9"  191 lbs.
    Join Date
    Oct 2006
    Posts
    9,837
    Rep Power
    2469152
    Level
    76
    Lv. Percent
    80.81%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Yes, I use it and am 195lbs and sub 8%bf. It's nothing to be worried about, I know plenty of others who do. I understand the point, but you're majoring in the minors here.
    Serious Nutrition Solutions Representative
  5. New Member
    johnnyp's Avatar
    Stats
    6'1"  1? lbs.
    Join Date
    May 2012
    Posts
    177
    Rep Power
    138940
    Level
    19
    Lv. Percent
    91.96%

    Berberine induced Atrogin-1/AMPk
    Quoting Mr.Cooper
    "Yeah I've seen this. It was demonstrated in normal mice too, but I think the key here is understanding the big picture. Yes, berberine potently induces AMPK, but in trained individuals, this will simply increase glucose flux (and subsequent glycogen storage) in muscle tissue. In the context of a high protein diet (lots of mTOR signaling) and resistance training, me thinks the effects would be rather negligible. We don't see people on berberine or metformin catabolizing ridiculous amounts of muscle tissue typically "
  6. Senior Member
    aaronuconn's Avatar
    Stats
    5'10"  182 lbs.
    Join Date
    Jun 2011
    Posts
    2,480
    Rep Power
    1912907
    Level
    59
    Lv. Percent
    43.35%
    Achievements Activity AuthorityActivity ProPosting Pro

    I'm guessing this is due to Berberine's effect on AMPK. I wouldn't be overly concerned.
    PES - Physique Enhancing Science
  7. Enhanced Body Formulations
    EBF Inc's Avatar
    Join Date
    Apr 2012
    Posts
    4,772
    Rep Power
    1704913
    Level
    68
    Lv. Percent
    13.43%
    Achievements Activity ProActivity AuthorityPosting Pro

    This issue has been beaten down

    I've yet to see much in the way of muscle loss from any berberine containing product
    Enhanced Body Formulations Product Educator

    For any questions on our products that need a quick response, please email me directly
    EnhancedBodyFormulations@gmail .com
  

  
 

Similar Forum Threads

  1. Replies: 16
    Last Post: 04-06-2012, 05:07 PM
  2. SHR 7/29 Muscle Protein Synthesis Occurs While Fasted
    By triceptor in forum Super Human Radio
    Replies: 3
    Last Post: 08-02-2011, 01:18 AM
  3. Replies: 19
    Last Post: 05-31-2008, 06:38 AM
  4. Replies: 12
    Last Post: 11-24-2004, 03:46 AM
  5. Replies: 1
    Last Post: 03-03-2003, 12:37 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in