Curcumin - Longvida vs Meriva

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  1. Curcumin - Longvida vs Meriva




    Both of those brands use some form of phospholipid, but the two formulas do not have identical absorption.
    Meriva (sold by Thorne) has a small human study showing benefit using two capsules twice a day for osteoarthritis, but that is only based on subjective data (pain and functionality scales rather than serum inflammatory markers).
    Usana (a large supplement company) analyzed Meriva bioavailability and here is what they said:
    Free curcumin could not be detected in any plasma samples, in accordance with previous studies that have mostly failed to detect unconjugated curcumin in human plasma even after the administration of megadoses of curcumin.
    However, Usana did find some metabolites of curcumin (referred to as ‘curcuminoids’):
    The peak plasma total curcuminoid concentration (Cmax) reached with the high dosage of Meriva was 206.9 ng/mL…. [However] Within the context of curcumin human absorption, the >200 ng/mL concentration of conjugated curcuminoids is still lower than the low micromolar concentration of free curcumin required for direct activity against its various targets. 6
    In addition, some studies suggest that although some of the curcuminoid metabolites have anti-inflammatory effects (and thus may be helpful against arthritis, which is what Meriva is marketed for), only curcumin, not its metabolites, will work against Alzheimer’s:
    Despite dramatically higher drug plasma levels after administering [the curcuminoid metabolite] tetrahydro-curcumin… only curcumin was effective in reducing amyloid plaque burden. Tetrahydro-curcumin had no impact on [Alzheimer’s] plaques or insoluble Amyloid-β… Curcumin, but not tetrahydro-curcumin, prevented Amyloid β aggregation. 7
    Therefore, for prevention of Alzheimer’s, Longvida is the better choice.
    Curcumin: Not all brands are created equal!
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard


  2. I've recently used a product called Curamin, the Extra Strength version. Very effective anti-inflammatory. It uses BCM-95 which is some sort of patented curcumin extract. It also contains a patented form of Boswellia extract.

    Stuff worked pretty darn well on relieving my shoulder issue when I had the issue. I stopped using it after the issue went away though since supposedly the stuff is a strong COX-2 inhibitor and also inhibits ArA formation.

    So, yeah, I think the type of curcumin most certainly can play a part on how effective the stuff is. I think in general, curcumin is said to have pathetically bad bioavailibility?
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  3. here's a great breakdown to make it simple for anyone with questions or confused about curcumin - Supplement Truths: Caught between Offit and Oz

    Go down to Part 3: The lowdown on Curcumin


    Furthermore

    It looks like Theracurmin seriously misleads with the way they present their data. The short version is, they give you the impression that their awesome absorption is of free curcumin, when actually it is of curcumin metabolites– which are much easier to measure from any brand. Furthermore I have now seen a Theracurmin trial in pancreatic cancer which shows no activity despite the tremendous “absorption”– and in the (very) fine print it turns out that it’s not free curcumin at all… which is probably why there is no effect. So I’m now back to recommending Longvida instead… certainly for Alzheimer’s and probably for cancer prevention too. - See more at: Curcumin update: What about Theracurmin?



  4. Quote Originally Posted by kissdadookie View Post
    I've recently used a product called Curamin, the Extra Strength version. Very effective anti-inflammatory. It uses BCM-95 which is some sort of patented curcumin extract. It also contains a patented form of Boswellia extract.

    Stuff worked pretty darn well on relieving my shoulder issue when I had the issue. I stopped using it after the issue went away though since supposedly the stuff is a strong COX-2 inhibitor and also inhibits ArA formation.

    So, yeah, I think the type of curcumin most certainly can play a part on how effective the stuff is. I think in general, curcumin is said to have pathetically bad bioavailibility?
    This post is way off. Curcumin is a TNF-alpha inhibitor, and furthermore, ArA formation is never inhibited by ANY anti-inflammatory.

  5. There was a pretty a good thread in the advance discussion section on Curcumin. I thought BCM-95 was the most popular?Seems like regardless of the "delivery system", it will be good for GI health.
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  6. Quote Originally Posted by aaronuconn View Post
    I thought BCM-95 was the most popular?.
    Maybe the most popular because many companies use it, but their studies are suspect
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  7. Quote Originally Posted by mr.cooper69 View Post
    This post is way off. Curcumin is a TNF-alpha inhibitor, and furthermore, ArA formation is never inhibited by ANY anti-inflammatory.
    Was just going by the product description for the Curamin product. Nothing more nothing less. If it's safe to continue taking it and not have it inhibit adaptation, let me know, I wouldn't mind continuing to use it as it's pretty effective.

    EDIT: Looked at the product description more carefully, so it looks like they are saying that the product blocks the inflammation response of the ArA cascade rather than blocking ArA formation.

    So, big question, is it ok to continue to take this stuff if it's blocking the inflammation response from the ArA cascade or better to use it as I was using it before, when I have some more serious joint pain?

  8. Quote Originally Posted by kissdadookie View Post

    So, big question, is it ok to continue to take this stuff if it's blocking the inflammation response from the ArA cascade or better to use it as I was using it before, when I have some more serious joint pain?
    not perhaps the best thing for fully utilizing ArA lucky for me I'm not a fan of ArA

    http://www.ncbi.nlm.nih.gov/pubmed/7784468
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  9. Quote Originally Posted by Touey View Post
    not perhaps the best thing for fully utilizing ArA lucky for me I'm not a fan of ArA

    http://www.ncbi.nlm.nih.gov/pubmed/7784468
    I meant for times when I'm not using ArA. Wondering if it's ok to still use the product if I dosed it away from a workout (like in the evening, I workout in the morning).

  10. Quote Originally Posted by kissdadookie View Post
    I meant for times when I'm not using ArA. Wondering if it's ok to still use the product if I dosed it away from a workout (like in the evening, I workout in the morning).
    you have to weigh the pros and cons for yourself kd, I take it this way like I do cissus and don't notice ill effects on workouts
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  11. Quote Originally Posted by Touey View Post
    you have to weigh the pros and cons for yourself kd, I take it this way like I do cissus and don't notice ill effects on workouts
    Yeah, I just didn't want to risk interfering with adaptation.

  12. Theracumin might be the strongest on the market right now, but I don't really know.

    "Theracurmin produces blood levels of curcumin metabolites in human and animal studies that are up to 300 times greater than regular curcumin and significantly greater than any other commercial form."
    Iconic Formulations Rep.
    APE = 25% off
    PM for help with our line.

  13. Quote Originally Posted by Ape McGrapes View Post
    Theracumin might be the strongest on the market right now, but I don't really know.

    "Theracurmin produces blood levels of curcumin metabolites in human and animal studies that are up to 300 times greater than regular curcumin and significantly greater than any other commercial form."
    Are the blood levels what we're after here, though?

  14. I have no clue. None at all.

    I use 300mg theracumin and 875mg of BCM-95 with bioperine.

    Doubt full I need to do anymore. That would seem obsessive.
    Iconic Formulations Rep.
    APE = 25% off
    PM for help with our line.

  15. Quote Originally Posted by Ape McGrapes View Post
    Theracumin might be the strongest on the market right now, but I don't really know.

    "Theracurmin produces blood levels of curcumin metabolites in human and animal studies that are up to 300 times greater than regular curcumin and significantly greater than any other commercial form."
    that's the problem it's curcumin metabolites not free curcumin.. I'd choose longvida, Now Foods will be coming out with it in a product soon
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  16. Quote Originally Posted by Touey View Post
    that's the problem it's curcumin metabolites not free curcumin.. I'd choose longvida, Now Foods will be coming out with it in a product soon
    I'll keep an eye out for it.

    Like I said though, I use the two different products to try and get a better blend persay.
    Iconic Formulations Rep.
    APE = 25% off
    PM for help with our line.

  17. Quote Originally Posted by Ape McGrapes View Post
    I have no clue. None at all.

    I use 300mg theracumin and 875mg of BCM-95 with bioperine.

    Doubt full I need to do anymore. That would seem obsessive.
    I ran into your thread because i use curcumin and glutathione... I was using a bcm-95 curcumin from LE but have changed a few of my supps to this company called maxhealthlabs. the curcumin and glutathione are a liposomal gel that comes in a packet. they deliver 100x better than all other supps.. my recovery time i feel, has gotten better since using the two products.... i do use their resveratrol also...

    Hope this helps out.

  18. Quote Originally Posted by Ape McGrapes View Post
    I'll keep an eye out for it.

    Like I said though, I use the two different products to try and get a better blend persay.
    http://www.nowfoods.com/CurcuBrain-4...g-Capsules.htm

    it's out should be in stores soon
    "To your wife you should kiss try today"-Touey

    Brotato's bark brings shakes to the pups in the yard

  19. Good topic.

    What about a liposomal? I have seen a couple brands of liposomal curcumin?

  20. Quote Originally Posted by FireRescue View Post
    Good topic.

    What about a liposomal? I have seen a couple brands of liposomal curcumin?
    Look at MaxHealthLabs Liposomal Curcumin..

    I use their Curcumin and the Glutathione..

    Also, i was reading in another article, about fish oils. look for Cardia7 Oil its a purified Omega7 that kills inflammation. Works for me...
    It is not a replacement for Omega 3 fish oils but is an inflammatory.

  21. Reviving an old thread. If my main goal was for anti inflammatory effects in the GI tract, and not as much systemically, would some of the less absorbable forms like BCM 95 be better options?

  22. Quote Originally Posted by boatnerj View Post
    Reviving an old thread. If my main goal was for anti inflammatory effects in the GI tract, and not as much systemically, would some of the less absorbable forms like BCM 95 be better options?
    If you are wanting to use it for that application, you could get away with just using a non enhanced curcumin. It would be much cheaper as well.

  23. Quote Originally Posted by boatnerj View Post
    Reviving an old thread. If my main goal was for anti inflammatory effects in the GI tract, and not as much systemically, would some of the less absorbable forms like BCM 95 be better options?
    I have had EXCELLENT luck with bulk 95% Curcumin and Bioperine - Anti-Inflamatory as heck for me (Achilles Tendon pain is GAWN bro's!) I "2 Heaping Red Micro-Scoop" the Bioperine - so it's a lot more than the typical 5mg used in stuff - but it's cheap in bulk and still way cheaper than pre-made Curcumin caps. I also add a good bit of bulk Ground Black Pepper (from Sam's Club) for good measure.

  24. bumping this thread back up...

    Trying to find a winner between the following types, or at least a ranking:

    1. Longvida
    2. Meriva
    3. theracumin
    4. BCM 95
    5. Curcuwin

  25. Quote Originally Posted by Max32 View Post
    bumping this thread back up...

    Trying to find a winner between the following types, or at least a ranking:

    1. Longvida
    2. Meriva
    3. theracumin
    4. BCM 95
    5. Curcuwin
    I've never used theracumin or curcuwin. However, for the other 3 my rankings are as follows:

    Anti-Inflammatory Effects (for me, lower back pain) - from best to worst
    1. BCM-95
    2. Meriva
    3. Longvida

    Mental/Nootropic Effects (for me, antidepressant/mood benefits) - from best to worst
    1. Longvida
    2. BCM-95
    3. Meriva
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