Pregnenolone long-term use...safe?
- 05-09-2014, 01:35 PM
Dude, you have lots of great info about under-appreciated supps. Between this thread and an ashwagandha thread awhile ago, you have really helped me a lot with your info (and probably others as well). FYI after trying sensoril I actually had better sedative results from the NOW ash for some reason and I have switched back to that. Weird, but I didn't question it and went back to what worked the best.
- 05-09-2014, 01:41 PM
Regarding preg, for some reason it seems to work best for me just taking it a couple of days a week. I took it several days in a row and stopped getting much from it. Then I took several days off and took it upon waking for my 12-hour day today and WOW. Between that and rhodiola (1g bulk powder), all day energy with almost no stims (75 mg from my green supplement first thing AM and a cup of milk tea with lunch and that actually felt like more of a kick than I wanted).
And my wife is STILL not bitchy at all and is thrilled to be feeling great and in better control of her emotions. She is taking it daily, so I guess she has more of a need for it than I do.
Best 10 bucks I ever spent
05-09-2014, 02:02 PM
05-09-2014, 02:04 PM
About your wife- isn't it the greatest thing in the world? We are lucky to have wives that are open to learning more about this and not shutting down or just wanting to mask things with a script.
05-12-2014, 04:33 PM
I have to say, pregnenolone and rhodiola are a great combo. Talk about a lot of energy, good mood and focus.
05-29-2014, 05:03 PM
Has anyone tried the micronized lipid matrix tablets (sustained release)? I'm curious as to how it compares to sublingual and transdermal.
05-29-2014, 07:06 PM
another option is dermacrine....transdermals have always worked better for me than sublinguals, and dermacrine contains both preg and dhea + the estrogen balancers trans-resveratrol and 7,8-benzoflavone.
06-23-2014, 10:04 AM
For those that use (or have used) both pregnenolone and Ashwagandha - have you noticed a reduction in Ashwagandha's calming effects? I recently read that pregnenolone may inhibit or block the GABA receptor.
06-23-2014, 10:24 AM
07-26-2014, 06:00 PM
Started taking 50 mg/day of pregnenolone as a slow release, micronized tablet and so far like it more than sublingual tablets. The focus, energy and mood benefits seem to last all day for me (versus the sublingual tablets which tended to fade in the early afternoon).
07-26-2014, 07:11 PM
07-26-2014, 07:19 PM
07-29-2014, 09:16 AM
Well, it appears the McPherson Labs 50mg tablet (which is the only dosage they sell) is a little too much for me. I started getting acne pretty bad a couple days ago. I've also noticed that while my sleep has greatly improved, it's almost too good. I have trouble waking up in the morning and am really groggy for a little while. However, I still really like the slow release action since the energy and mood benefits are very steady for me. Unfortunately, based on information provided by McPherson, their tablets can't be split without losing the slow release action. So, I'm going to order the Nutricology micronized lipid matrix, slow release tablets. Their lowest dosage tablet is also 50 mg but it's scored. So, it can be split without losing the time release action.
08-18-2014, 11:54 AM
The switch to micronized lipid matrix tablets was a failed experiment. I kept decreasing the dose but still had problems with waking up in the morning and feeling tired/groggy most of the day. I'm not sure why I had better energy and mood benefits at the beginning (placebo?). Well, back to sublingual tablets. They seem to be the best way to go.
08-18-2014, 01:59 PM
08-18-2014, 02:44 PM
08-18-2014, 05:14 PM
08-18-2014, 05:38 PM
01-19-2017, 02:23 AM
Anyone who posted here about positive experiences on pregnenolone still taking it? I'm a 34 year old guy with anxiety issues... tried a whole bunch of stuff with some success, but can't completely kick it. Head fog, and somewhat low energy are also an issue.
I want to try pregnenolone but am concerned about side effects. It seems like everyone here has had good experiences, but I have read about some bad withdrawal from pregnenolone, as well as long term hair loss. Also I'm taking an SSRI and a bit concerned about interaction with that, although I assume it shouldn't.
01-19-2017, 10:09 AM
There is zero withdrawal from pregnenolone so I don't know who or where you are getting that information from. I've taken it for years.
01-19-2017, 10:19 AM
01-19-2017, 10:41 AM
It's significant. There have been studies completed on it and anecdotally, there is nothing more useful to improve memory and learning. It would always be the first thing I would recommend to anyone 30+ looking to brain hack, but I don't because it is a hormone.
01-19-2017, 02:41 PM
01-19-2017, 02:49 PM
I like 10mg for maintenance and on the weekends I will sometimes go up 50mg for a nice recreational experience. Mood and energy are very elevated and makes activities very interesting. As close to a "Limitless" feeling I have found, but shouldn't be run at that level for extended times because it is hormone and can convert to estrogen.
01-19-2017, 04:25 PM
01-19-2017, 04:32 PM
01-19-2017, 06:22 PM
"Careful with this. I had a really hard time coming off of Pregnenolone, even at low doses. I didn't really have medical justification for using it, but it was great to combat stress and generally made me feel great. It works, but it was debilitating for me to come off of, even at 2.5 mg every other day."
I've only seen one guy say that, so maybe that's just a weird anomaly. Hair loss however does seem to be a more common side effect. Anyway, from all the amazing testimonials I've read about it I guess I gotta give it a go... especially since I've had mono which supposedly can cause pregnenolone problems. I would rather get my serum pregnenolone tested first, however I doubt I could convince an MD to get that done for me. I've had my DHEAS tested and it was pretty high (although testosterone was low), so I'm not sure if that means my pregnenolone is likely ok or not.
I assume the 10 mg you're taking is orally and not sublingual? I have 5 mg sublingual tablets which I was planning on cutting in half and starting with that every second or third day.
01-19-2017, 06:27 PM
I take sublingual. It is very easy to test for preg, DHEAS, and progesterone and quite common, so you would have no issue if you wanted to get tested.
The reddit post is 100% in that user's mind. There is no "coming off" of pregnenolone.
01-19-2017, 06:32 PM
01-19-2017, 06:34 PM
Sublingual works better for me. e2 tends to rise faster on oral and I maintain a good e2 level on sublingual form.
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