Higher ArA dosage, or ArA stack?

Page 3 of 5 First 12345 Last

  1. From what I can tell from reading information Neuron has posted:

    arachidonic acid --> triglyceride --> chylomicron --> interaction with enzyme Lipoprotein Lipase (LPL) --> "only isoform of LPL that is active with insulin is located on adipocytes".


  2. Quote Originally Posted by aaronuconn View Post
    From what I can tell from reading information Neuron has posted:

    arachidonic acid --> triglyceride --> chylomicron --> interaction with enzyme Lipoprotein Lipase (LPL) --> "only isoform of LPL that is active with insulin is located on adipocytes".
    Did he say that last statement? Both forms are active but the adipose form predominates with insulin
    •   
       


  3. Quote Originally Posted by mr.cooper69 View Post
    Did he say that last statement? Both forms are active but the adipose form predominates with insulin
    It's from his first post on the Maximizing AA to skeletal muscle on bb.com.

  4. Here's the entire first post from Neuron on the aforementioned thread:

    "I made a cursory glance into the X-Factor thread and I didn't see any suggestion on when to take X-Factor, or other Arachidonic acid products, so here is my suggestion.

    Background
    After ingestion, fatty acids like arachidonic acid are emulsifed and taken up into enterocytes where they are esterfied on a glycerol backbone to form a triglyceride. Next, the triglycerides and cholesterol esters are bound together to form a chylomicron. This entity can now diffuse into the lymphatics and then into the blood. Once in the blood, the chylomicrons are free to interact with various tissue receptors depending on energy homeostasis. When needed, they can interact with an enzyme called Lipoprotein Lipase (LPL) that will hydrolyze the triglycerides back into fatty acids to be used as fuel or for storage purposes.

    The point being...
    In which tissue the fatty acids are deposited is a function of the energetic state of the organism overall. In a post-prandial, high fed, state, the dominant hormone is insulin. Similarly, the only isoform of LPL that is active with insulin is located on adipocytes. It should be obvious now that consuming fats when eating will direct them to adipose. This isn't necessarily a bad thing in the context of fish oil, as adipose is now recognized as a great contributer to endogenous hormone production like the prostanoids.

    But...
    In the context of Arachidonic Acid, the final destination should be skeletal muscle. Luckily, there is an energetic state which favors fatty acid delievery to this tissue: Exercise (or acute starvation) [1]. In an exercise-induced environment, LPL on skeletal muscle becomes active which serves as an adjunct to glycolysis for the TCA cycle via beta-oxidation. Similarly, the enzyme DGAT also becomes active in skeletal muscle which functions to store excess fatty acids as triglycerides. Since both of these enzymes are heavily active during exercise, it is clear that an excess of fatty acids are being removed from blood plasma into skeletal muscle as a reservoir (this also serves to decrease insulin insensitivity [2]).

    Based on these observations
    To maximize ArA supplemention it is advisable to supplement 30-40 minutes prior to exercise in order to ensure plasma delievery of ArA and also to reduce exercises effects on gastric motility."

    [1] http://ajpendo.physiology.org/cgi/co...act/268/2/E229
    [2] http://ajpendo.physiology.org/cgi/co...act/294/5/E882

  5. Happy to hear that the stack I'm starting in a couple of weeks should be pretty kick ass.

    ArA + ABE + GMS + LCLT. (maybe Amino IV, too)
    •   
       


  6. Yeah, I make sure to take 1.5gms at least 45 minutes to an hour before I work out.

  7. Quote Originally Posted by doggy_dog View Post
    Happy to hear that the stack I'm starting in a couple of weeks should be pretty kick ass.

    ArA + ABE + GMS + LCLT. (maybe Amino IV, too)
    I'm doing the same stack, starting in mid Feb
    PES REPRESENTATIVE
    pescience.com
    http://pescience.com/insider

  8. Quote Originally Posted by doggy_dog View Post
    Happy to hear that the stack I'm starting in a couple of weeks should be pretty kick ass. ArA + ABE + GMS + LCLT. (maybe Amino IV, too)
    Throw some Agmatine in too

  9. Quote Originally Posted by Misfit28 View Post
    Throw some Agmatine in too
    Pumps would hurt too much lol (kinda srs)

  10. Quote Originally Posted by kbayne View Post
    Pumps would hurt too much lol (kinda srs)
    Lol, may get counterproductive.

  11. Quote Originally Posted by kbayne View Post
    Pumps would hurt too much lol (kinda srs)
    Good point! I've just recently fallen in love with Agmatine. Not just the pump aspect (which is awesome), but the neurological/mood effects for me

  12. What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.

  13. Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    It's uptake into adipose. Insulin facilitates it I believe

  14. Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    Drop the carbs if possible and dose Ara completely fasted
    Serious Nutrition Solutions Representative
    X-gels for strength, Focus XT for mental performance & Joint Support XT for pain free mobility

  15. Im running ArA with Glycergrow & hemoval and ABE, except ive been dosing ABE with my biggest meals... gotta start dosing PWO I suppose
    http://anabolicminds.com/forum/powerlifting-strongman/240580-road-derby-cup.html

  16. Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    As Jiigzz stated, I would drop the Glycofuse pre-workout and dose your ArA fasted.

  17. Quote Originally Posted by HITFrank View Post
    What are the conclusion on the carbs with ARA?

    I take 25g Glycofuse with my ARA + PWO + LCLT + GMS + AminoIV pre-workout and 25g Glycofuse + AminoIV intra-workout.
    save the carbs for postWO or eat slightly more carbs with other meals if worried about losing those carbs/calories in order to maximize your ArA

    Darren and NP are too awesome, still selling X-Factor and XFA for right around $30!

    http://www.nutraplanet.com/product/m...-softgels.html
    Molecular Nutrition - Unlevel The Field
    X-Factor: THE Most Scientifically Valid Muscle Builder, Ever!
    Sign up for INSANE deals via our newsletter: www.mninsider.com

  18. Quote Originally Posted by SwolenONE View Post

    save the carbs for postWO or eat slightly more carbs with other meals if worried about losing those carbs/calories in order to maximize your ArA

    Darren and NP are too awesome, still selling X-Factor and XFA for right around $30!

    http://www.nutraplanet.com/product/m...-softgels.html
    Or use FORSKOLIN with ara

    Start training. Wait till set 4-8 and then start your carbs

  19. Quote Originally Posted by EBF Inc View Post
    Or use FORSKOLIN with ara

    Start training. Wait till set 4-8 and then start your carbs
    I just picked up some Forskolin 50.

  20. Is there a time frame after taking ARA where carbs shouldn't be consumed? 2-3 hours or less?

  21. Quote Originally Posted by Johnston View Post
    Is there a time frame after taking ARA where carbs shouldn't be consumed? 2-3 hours or less?
    Well start training this way phospholipase a2 does its job and ara get to those muscle cells. After that I don't see a reason to avoid carbs IMO

    Use the FORSKOLIN to prevent any ara dependant adipocyte differentiation (when insulin is present).

  22. Quote Originally Posted by Johnston View Post
    Is there a time frame after taking ARA where carbs shouldn't be consumed? 2-3 hours or less?
    I still keep my intra workout carbs in place
    Serious Nutrition Solutions Representative
    X-gels for strength, Focus XT for mental performance & Joint Support XT for pain free mobility

  23. Quote Originally Posted by Jiigzz View Post

    I still keep my intra workout carbs in place
    So do I I just start drinking between sets 4 and 8

  24. Quote Originally Posted by EBF Inc View Post
    Well start training this way phospholipase a2 does its job and ara get to those muscle cells. After that I don't see a reason to avoid carbs IMO

    Use the FORSKOLIN to prevent any ara dependant adipocyte differentiation (when insulin is present).
    Carbs are avoided to keep a higher relative activity of LPL in muscle vs fat (nothing to do with PLA2).

    But for the last time (and I mean the last time, not to you EBF, but to people asking the Qs as I've probably said this 25+ times now in the past month), if you are exercising, carbs/amino acids consumed with ArA won't matter. So take them all preworkout if you want and get to it

  25. Any thoughts on ARA/forskokin combo in PCT?
  •   

      
     

Similar Forum Threads

  1. Arachidonic Acid (ArA) Alone or with Fish Oil?
    By w_llewellyn in forum Supplements
    Replies: 13
    Last Post: 03-03-2014, 10:40 PM
  2. Should I add ArA do this cutting stack?
    By doggy_dog in forum Supplements
    Replies: 18
    Last Post: 11-20-2013, 04:10 AM
  3. Replies: 0
    Last Post: 06-02-2011, 03:48 AM
  4. Any advice on higher dosage of Trifecta stack??
    By Frtdrmrose7 in forum LG Sciences
    Replies: 18
    Last Post: 04-08-2010, 11:30 PM
  5. Need dosages for cutting stack
    By Bigmac in forum Supplements
    Replies: 0
    Last Post: 04-17-2003, 08:08 PM
Log in
Log in