- 01-07-2014, 12:41 PM
Has anyone seen these studies on bcaas. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049458/ http://www.ncbi.nlm.nih.gov/m/pubmed/20832409/Knowledge is power- The power to do your part and make a difference.
- 01-07-2014, 02:14 PM
They're stretching a wee bit***PES Representative***
01-10-2014, 01:34 AM
01-10-2014, 10:55 AM
The first one isn't a study, but an intro and summary of the second one. The second one, the paper by Carunchio et al., found that if you feed mice BCAAs, then they show neuronal hyperexcitability in culture and slice preps (both of these preps of course lose regulation that would be there in vivo in an intact brain). The hyperexcitability that they observed is similar to what was observed in their genetic model of ALS which uses a mutation in SOD1 (note that over 100 mutations in SOD1 have been linked with ALS and they are running with just one of those). Nobody has been able to actually show a link between this hyperexcitability and ALS, though there is a lot of interest in that area. So yes, they are stretching.
01-10-2014, 11:52 AM
01-10-2014, 11:57 AM
01-10-2014, 01:57 PM
what? a study that is full of shinola? impossible
LOL wow I have seen it all now, BCAAs cause ALS
NOW we finally know what PEDs Lou Gehrig was using back in 1930...
01-10-2014, 02:01 PM
honestly seems like they have tons of studies that say that something is bad for you then they will have just the same amount or more that say that it will do no harm. these studies should be read but just keep in mind that there are more studies
01-10-2014, 06:35 PM
01-10-2014, 06:50 PM
01-10-2014, 07:06 PM
01-10-2014, 07:12 PM
01-10-2014, 07:30 PM
01-10-2014, 07:52 PM
01-10-2014, 08:06 PM
01-10-2014, 08:57 PM
01-11-2014, 12:14 AM
01-11-2014, 12:25 AM
I didn't realize you were replying to that "mess up your brain question." I agree - there is no firm evidence to support such a claim. I did notice the study on some other forums after OP posted it here.
The BCAA-sporadic ALS-hyperexcitability concept is intersting but far from conclusive. ALS is a confounding condition whose genesis is poorly understood. But people who suffer from this horrific condition would likely welcome any research.
01-11-2014, 10:48 AM
But here is my problem with the link to ALS. This group found a phenomenon that does not occur in ALS and has not been shown to have any link to ALS. This phenomenon occurs in their very specific genetic model of ALS, of which there are literally hundreds and every group thinks their model is the answer. However, finding a cool physiological phenomenon isn't always enough to get a paper published in the journal that they want to publish in, so they have to bedazzle it and talk about something that will catch people's attention.
I do sympathize with individuals and families that suffer from ALS and other diseases. I also know firsthand how much funding for this research completely blows and the need to exaggerate to get findings out in the public, but that can also give those suffering from these diseases false hope.
01-11-2014, 11:23 AM
Good points all around and I concur re: the dangers of overzealous extrapolation.
01-11-2014, 09:59 PM
You make a very valid point about the desire for papers to get published and the often sensationalistic headlines/conclusions. One would hope medical professionals would not succumb to such base tactics but scientists are flawed like the rest of us. I try to keep that in mind and maintain a critical eye.
I applaud any research of this nature. All diseases bring varying degrees of pain and challenges but neurodegenerative diseases are a special piece of hell. People in my family have died and are afflicted currently by such diseases, which more often than not lack robust treatment options.
01-11-2014, 10:02 PM
01-12-2014, 10:03 AM
01-14-2014, 12:34 AM
01-14-2014, 01:55 AM
in actuality, you used the premise of their intelligence, as your sole basis for agreeing with their elusive "conclusion"
you cited no factual relevance of your own
that would be called an appeal to authority
ie, a worthless extrapolation
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