Has anyone seen these studies on bcaas. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049458/ http://www.ncbi.nlm.nih.gov/m/pubmed/20832409/
Me? No. I already drank my first of the day PES Amino IV this morning and will have another tonight during training. I'm saying that this study makes huge leaps using limited science and has shown absolutely no correlation between their findings and what they claim their findings say.So your saying bcaa s could really mess your brain up?
Thanks for posting - first time I've seen this. ALS is a severe neurodegenerative disorder and a devastating diagnosis. This study raises some interesting questions. The Carunchio et al study is dated 2010; I will check to see if similar research has been published since that time.MonteHas anyone seen these studies on bcaas. Stronger is not always better: could a bodybuilding dietary supplement lead to ALS? Increased levels of p70S6 phosphorylati - PubMed Mobile
That's a bit dismissive, isn't it? In response, the scientists from Northwestern Univeristy prepared a reasonable critique, saying the data is thought-provoking but more work needs to be done. I only have access to the Carunchio abstract but it didn't appear to make definitive comments around the relationship between BCAA consumption and sporadic ALS. MonteMe? No. I already drank my first of the day PES Amino IV this morning and will have another tonight during training. I'm saying that this study makes huge leaps using limited science and has shown absolutely no correlation between their findings and what they claim their findings say.
Alex is very educated. I trust his opinion on the matterThat's a bit dismissive, isn't it? In response, the scientists from Northwestern Univeristy prepared a reasonable critique, saying the data is thought-provoking but more work needs to be done. I only have access to the Carunchio abstract but it didn't appear to make definitive comments around the relationship between BCAA consumption and sporadic ALS. Monte
The scientists from Northwestern University are very educated, as well.Alex is very educated. I trust his opinion on the matter
But without reading the FT, you have no idea how substantive the evidence is.The scientists from Northwestern University are very educated, as well.
You're right - I don't. But the Northwestern U. scientists do and they wrote what seems like a balanced response. I think it's worth reading.But without reading the FT, you have no idea how substantive the evidence is.
Most studies than cannot find causation state that further research is necessary.You're right - I don't. But the Northwestern U. scientists do and they wrote what seems like a balanced response. I think it's worth reading.
Can you please link me to the critique you mentioned, I probably know them. And I didn't mean to be so harsh towards the article, but I still maintain that they shouldn't even mention ALS which they do. I was more responding to "So your saying bcaa s could really mess your brain up?" when I was pretty clear why this study shows absolutely zero link between BCAA and ALS. A quick net search will show that this article has been used on several other boards to try and show that there is a link and I am trying to avoid that.That's a bit dismissive, isn't it? In response, the scientists from Northwestern Univeristy prepared a reasonable critique, saying the data is thought-provoking but more work needs to be done. I only have access to the Carunchio abstract but it didn't appear to make definitive comments around the relationship between BCAA consumption and sporadic ALS. Monte
True. And that is a fair position for a researcher to take when the evidence is inconclusive.Most studies than cannot find causation state that further research is necessary.
Aleks, I was referring to this one: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049458/Can you please link me to the critique you mentioned, I probably know them. And I didn't mean to be so harsh towards the article, but I still maintain that they shouldn't even mention ALS which they do. I was more responding to "So your saying bcaa s could really mess your brain up?" when I was pretty clear why this study shows absolutely zero link between BCAA and ALS. A quick net search will show that this article has been used on several other boards to try and show that there is a link and I am trying to avoid that.
I read that as well, but dismissed it as it isn't a study itself. It's a book report on the Carunchio paper written by a post-doc. Here's my issue with both and hopefully it will give you a better picture of why I have issues with them even mentioning ALS. The Carunchio paper found an interesting physiological phenomenon. They fed mice BCAA and saw hyperexcitability in some neurons that were either cultured in a dish or in a brain slice. Both of these brain preps are important and have led to an endless amount of medical science breakthroughs, but I still am more convinced when people repeat these experiments in vivo in an intact animal, partially because that is what I have done and partially because hyperexcitability can easily rely on those connections that are lost when the brain is not intact. It's also a pretty generic phenomenon that can be caused by countless reasons.Aleks, I was referring to this one: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049458/
I didn't realize you were replying to that "mess up your brain question." I agree - there is no firm evidence to support such a claim. I did notice the study on some other forums after OP posted it here.
The BCAA-sporadic ALS-hyperexcitability concept is intersting but far from conclusive. ALS is a confounding condition whose genesis is poorly understood. But people who suffer from this horrific condition would likely welcome any research.
Aleks, terrific points. I often enjoy reading the book report/critique papers published in response to actual studies. It's refreshing to see other experts in the field comment on the data.I read that as well, but dismissed it as it isn't a study itself. It's a book report on the Carunchio paper written by a post-doc. Here's my issue with both and hopefully it will give you a better picture of why I have issues with them even mentioning ALS. The Carunchio paper found an interesting physiological phenomenon. They fed mice BCAA and saw hyperexcitability in some neurons that were either cultured in a dish or in a brain slice. Both of these brain preps are important and have led to an endless amount of medical science breakthroughs, but I still am more convinced when people repeat these experiments in vivo in an intact animal, partially because that is what I have done and partially because hyperexcitability can easily rely on those connections that are lost when the brain is not intact. It's also a pretty generic phenomenon that can be caused by countless reasons.
But here is my problem with the link to ALS. This group found a phenomenon that does not occur in ALS and has not been shown to have any link to ALS. This phenomenon occurs in their very specific genetic model of ALS, of which there are literally hundreds and every group thinks their model is the answer. However, finding a cool physiological phenomenon isn't always enough to get a paper published in the journal that they want to publish in, so they have to bedazzle it and talk about something that will catch people's attention.
I do sympathize with individuals and families that suffer from ALS and other diseases. I also know firsthand how much funding for this research completely blows and the need to exaggerate to get findings out in the public, but that can also give those suffering from these diseases false hope.
Steve, thanks. The dangers of "overzealous extrapolation" - I like that and will use it in the future.Good points all around and I concur re: the dangers of overzealous extrapolation.
that too is a very dangerous extrapolationThe scientists from Northwestern University are very educated.
Stating that scientists from a highly regarded university are "highly educated" is anything but "dangerous extrapolation."that too is a very dangerous extrapolation
"well they are scientists at a big school, so the study MUST have some merit"
1+1 does not always = 2, in the land of scientific studies
you went a little beyond thatStating that scientists from a highly regarded university are "highly educated" is anything but "dangerous extrapolation."
You need a lesson in reading comprehension. Nowhere in this post did I agree with their conclusions. I said their opinion deserves to be considered as it raised interesting questions. I agreed with Aleks' critique on numerous points; just stated the Northwestern critique deserves to be heard, as well.you went a little beyond that
in actuality, you used the premise of their intelligence, as your sole basis for agreeing with their elusive "conclusion"
you cited no factual relevance of your own
that would be called an appeal to authority
ie, a worthless extrapolation
Really? That is the dumbest think iv heard all day!!!!I did a study. Bcaa's didn't ruin my brain. And I'm a genius.
WowReally? That is the dumbest think iv herd all day!!!!
Heard*Really? That is the dumbest think iv herd all day!!!!
speechless!!Really? That is the dumbest think iv herd all day!!!!
For every study, there is a counter study:I did a study.
Bcaa's didn't ruin my brain. And I'm a genius.
Really? That is the dumbest think iv herd all day!!!!
It was a double blind study by Ray Charles and Homer.For every study, there is a counter study:
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