Thank you for the clarification, that is why I asked. Many people use GDAs whilst bulking with the thought process that they are preferentially shuttling carbohydrates into skeletal muscle even when the MOA of the ingredient isn't this. A couple of examples where the data supporting it's use is good but not necessarily the MOA you are looking for. Green coffee bean: "The mechanism(s) of the significant effects of GCA on weight loss, BMI, percent body fat, and heart rate are unknown. There have been some recent articles indicating that chlorogenic acid and its metabolite, caffeic acid, inhibit amylase at mM concentrations in vitro which, if it occurred in the gastrointestinal tract in vivo, would inhibit sugar absorption from starch consumption and thus decrease caloric input.12 That chlorogenic acid has a significant influence on glucose metabolism was well demonstrated by Rodrigues de Sotillo et al when they were able to demonstrate a significant improvement in glucose tolerance in Zucker rats.13 This relative deprivation of glucose could possibly explain the reduction in BMI as well as fat content seen in their other rat study14 and in our human study. Another group has clearly demonstrated that chlorogenic acid may in fact have an antagonistic effect on human glucose transport.15 Based on the dietary data in our study, the product was not an appetite suppressant. Extracts of green coffee beans inhibited pancreatic lipase in vitro with a 50% inhibitory concentration of 43 ?M polyphenols.16 In support of this result, caffeinated but not decaffeinated coffee supplementation in humans produced a decrease in lipoprotein lipase.17"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267522/ --- Gymnema sylvestre; "Gymnemic acid formulations have also been found useful against obesity, according to recent reports [10]. This is attributed to the ability of gymnemic acids to delay the glucose absorption in the blood. The atomic arrangement of gymnemic acid molecules is similar to that of glucose molecules. These molecules fill the receptor locations on the taste buds thereby preventing its activation by sugar molecules present in the food, thereby curbing the sugar craving. Similarly, Gymnemic acid molecules fill the receptor location in the absorptive external layers of the intestine thereby preventing the sugar molecules absorption by the intestine, which results in low blood sugar level [11]. Gymnema leaf extract, notably the peptide 'Gurmarin', has been found to interfere with the ability of the taste buds on the tongue to taste sweet and bitter. Gymnemic acid has a similar effect. It is believed that by inhibiting the sweet taste sensation, people taking it will limit their intake of sweet foods, and this activity may be partially responsible for its hypoglycemic effect [14]. There are some possible mechanisms by which the leaves and especially Gymnemic acids from G. sylvestre exert its hypoglycemic effects are: 1) it increases secretion of insulin, 2) it promotes regeneration of islet cells, 3) it increases utilization of glucose: it is shown to increase the activities of enzymes responsible for utilization of glucose by insulin-dependant pathways, an increase in phosphorylase activity, decrease in gluconeogenic enzymes and sorbitol dehydrogenase, and 4) it causes inhibition of glucose absorption from intestine. The gymnemic acid components are believed to block the absorption of glucose in the small intestine, the exact action being unknown. It could be involve one or more mechanisms [14].
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170951/