Cordysterone

[Grayson]

Does anyone know where to find this?

http://www.genabolix.com/yydetailpro.php?id=69#pa

 

[Grayson]

PR from their site:

I. What is Cordysterone™?
*Cordysterone™ is the branded product of Cordycepin presented by GENABOLIX.
*Cordycepin is the main active constituent of Cordyceps, one kind of amazing medicinal fungi.
*Cordysterone™can enhance Testosterone production.
*Cordysterone™ can regulate immune system.
*Cordysterone™ has nootropic effects.
*Cordysterone™ also has numerous other healthy effects.
II. The Amazing Treasure: Cordyceps
Cordyceps is a genus of sac fungi that includes about 400 identified species and many yet to be described. All Cordyceps species are endoparasitoids, mainly on insects and other arthropods; a few are parasitic on other fungi. Until recently, the best known species of the genus is Cordyceps sinensis, called “Dong Chong Xia Cao” in Chinese, meaning winter worm summer grass. [1]
Cordyceps has a long history as medicinal fungi. The earliest clear record is a Tibetan medical text in the 15th century outlining the tonic propensities of Cordyceps sinensis, especially as an aphrodisiac.[1]
Now people realize that Cordyceps is very beneficial to human health, including pro-sexual, anti-inflammatory, anti-oxidant, anti-aging, anti-tumor, anti-leukemic, anti-proliferative, anti-metastatic, immunomodulatory, anti-microbial, anti-bacterial, anti-viral, anti-fungal, larvicidal, anti-fibrotic, steroidogenic, anti-diabetic, anti-HIV, anti-malarial, anti-fatigue, neuroprotective, liver-protective, reno-protective as well as pneumo-protective, let alone their other synergistic activities, which let it be marketable in western countries as over-the-counter medicine or tonics.
With the development of biotechnology and medicine, more and more in vitro and in vivo models provide preliminary support for some of the traditional medicinal uses. Scientists also discovered the main active constituent of Cordyceps fruiting bodies is Cordycepin, which was first extracted from Cordyceps militaris and then found to be present in natural Cordyceps sinensis and cultured Cordyceps.

III. Cordycepin
The main active constituent of Cordyceps fruiting bodies is Cordycepin, and Cordycepin has not been found in any other species. Cordycepin, also known as 3'-Deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter only by the absence of oxygen in the 3' position of its ribose part.
Because Cordycepin is so similar to adenosine, some enzymes cannot discriminate between the two. For example, Cordycepin can function as normal building bloc of DNA, having the ability to confuse the DNA synthetic enzyme, Terminal Deoxynucleotidyl Transferase, and it also can be incorporated into RNA molecules, thus causing the premature termination of RNA synthesis.[2] With this capability, Cordycepin has broad applicability for disease treatment.

IV. Functions of Cordycepin
1. Testosterone Booster
Long ago people found Cordyceps was good for male reproductive system. With the help of modern molecular biology, scientists find the key constituent of Cordyceps, Cordycepin, plays an important role as a bioactive metabolite in the regulation of male reproductive tissues.
In one research, researchers investigated the in vivo and in vitro effects of Cordycepin in primary mouse Leydig cell steroidogenesis. [3] The results indicated that Cordycepin significantly increased the plasma Testosterone concentration. Cordycepin also stimulated in vitro mouse Leydig cell Testosterone production in dose- and time-dependent manners.
As mentioned above, Cordycepin resembles adenosine in chemical structure, so the metabolic pathways of Cordycepin inside body should closely mimic those of adenosine. Researchers in the study proved this hypothesis. It has been confirmed that mouse testis contains several adenosine receptors, and Cordycepin activates the cAMP-PKA signal transduction pathway to induce StAR protein expression, and then to enhance Testosterone production, possibly by exerting its effect through adenosine subtype receptors A1, A2a, and A3.
According with the Testosterone elevation report, another research found long-term administration of Cordycepin could reverse the decline of testicular function induced with age. [4] In this research, scientist divided the rats into young group, middle-aged group and Cordycepin-treated middle-aged group. The middle-aged group exhibited epididymal weight loss, decreased sperm motility, and reduced spermatogenesis compared to the young control group. Interestingly, the epididymal weights of middle-aged rats were dose-dependently increased by long-term treatment with Cordycepin. Cordycepin also improved calcium levels and decreased urea and nitrogen, uric acid, and creatinine in the blood of middle-aged rats. In addition, Cordycepin significantly increased sperm motility and the progressiveness of sperm movement. All Cordycepin-treated groups showed well-arranged spermatogonia, densely packed cellular material, and increased numbers of mature spermatozoa in the seminiferous lumen compared to the middle-aged control group.

2. Anti-tumor
The anti-tumor function of Cordyceps has been widely known. As the main ingredient of Cordyceps, the anti-tumor ability of Cordycepin has also been proved.
In one Japanese report, the anti-tumor effect of orally administered Cordycepin was examined in mice inoculated with B16 melanoma cells. [5] Results showed that Cordycepin (15 mg/kg per day, 2 weeks) significantly reduced by 36% the wet weight of the primary tumor lump compared to that of the untreated control mice, without any loss of bodyweight or systemic toxicity.
An early paper once talked about the mechanism of this famous function of Cordycepin. [6] Cordycepin is an analogue of adenosine lacking the 3'-OH, which makes it easily incorporated into a growing RNA molecule instead of adenosine. Cordycepin prevents further elongation, thus producing a prematurely terminated RNA molecule. The synthesis of transfer RNA is also found to be reduced in the presence of Cordycepin. By this way the growth of tumor cells is attenuated.

3. Nootropics
Cordycepin also has great potency in Nootropics.
In one research, scientists used Y-maze test to assess Cordycepin on learning and memory in mice. [7] And then they found that oral Cordycepin administration at dose of 10mg/kg significantly improved Y-maze learning performance both in healthy and ischemic mice. The data in this study provided valuable evidence that Cordycepin may act as a nootropic product or potential clinical application in improving cognitive function of patients with ischemic stroke in the future.
There’s another interesting report of sleep regulation function of Cordycepin. [8]In this research, sleep was recorded using electroencephalogram (EEG) for 4 hours after oral administration of Cordycepin (2 and 4mg/kg) in rats. Sleep architecture and EEG power spectra were analyzed. At last, Cordycepin reduced sleep-wake cycles, significantly increased nonrapid eye movement sleep and suppressed waking, which means the improvement of sleep quality. Therefore, Cordycepin, targeting on adenosine receptors, can be helpful for sleep disturbance subjects. Thus, the results also indicated a role for Cordycepin, an adenosine analogue, in the regulation of sleep and held promise for a new class of compounds as potential agents in the treatment of sleep disorders, such as insomnia.

4. Immunoregulatory
Another important merit of Cordyceps is its immunoregulatory activity. In fact, many therapeutic effects of traditional Chinese medicine Cordyceps on some diseases, such as asthma and nephritis, may be due to its immunoregulatory effects on human body.
One research investigated the regulatory effects of Cordycepin and Cordyceps sinensis on human immune cells. [9]The results showed Cordycepin and Cordyceps sinensis intensively regulated the functions of human immune cells in vitro. They both promoted the expression of IL-1β, IL-6, IL-8, IL-10 and TNF-α of resting cells, and inhibited the PHA-induced expression of IL-2, IL-4, IL-5, IL-12, IFN-γ and TNF-α. These results led to the opinion that Cordycepin and Cordyceps sinensis pleiotropically affected the actions of immune cells and cytokine network in a similar fashion. Cordycepin could be an important immunoregulatory active ingredient in Cordyceps sinensis.

V. Application of Cordysterone™
Cordyceps has traditionally been a prized Chinese folk medicine for the human well-being. Hundreds of years passed, it is still one of the most important candidates that may be used as the herbal medicinal bases in the future for the welfare of mankind. As the focus constituent of Cordyceps, Cordycepin possesses almost the same healthy effects, which is proved by more and more scientific researches.
Our Cordysterone™ is the very high-quality purified Cordycepin product. Although the brand is named from its Testosterone booster effect, Cordysterone™ has numerous beneficial functions for human health. It helps regulate users’ immune systems, improve sleep quality, strengthen memory and prevent diseases.
For Testosterone booster and male reproductive function, the recommended dosage is 100mg/serving.
For immunoregulatory or nootropic purpose, the recommended dosage is 50mg/serving.

VI. Reference
1. http://en.wikipedia.org/wiki/Cordyceps
2. http://en.wikipedia.org/wiki/Cordycepin
3. Sew-Fen LEU, Song Ling Poon, et al. The in vivo and in vitro stimulatory effects of Cordycepin on mouse Leydig cell steroidogenesis. Biosci. Biotechnol. Biochem., 75(4), 723-731, 2011.
4. Sang-Hyun Sohn, Su-Chan Lee, et al. Effect of Long-term Administration of Cordycepin from Cordyceps militaris on Testicular Function in Middle-aged Rats. Planta Med 2012; 78: 1620–1625.
5. Noriko Yoshikawa, Kazuki Nakamura, et al. ANTITUMOUR ACTIVITY OF CORDYCEPIN IN MICE. Clinical and Experimental Pharmacology and Physiology (2004)31, S51–S53.
6. MOSHE SIEV, ROBERT WEINBERG, and SHELDON PENMAN. THE SELECTIVE INTERRUPTION OF NUCLEOLAR RNA SYNTHESIS IN HELA CELLS BY CORDYCEPIN. TUE JOURNAL OF CELL BIOLOGY, VOLUME 41, 1969
7. Zhao-Lin Cai, Chun-YangWang et al. Effects of cordycepin on Y-maze learning task in mice. European Journal of Pharmacology, 714(2013)249–253.
8. Zhenzhen Hu, Chung-Il Lee, et al. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats. Evidence-Based Complementary and Alternative Medicine. Volume 2013.
9. Xiaoxia Zhou, Liping Luo, et al. Cordycepin is an Immunoregulatory Active Ingredient of Cordyceps sinensis. The American Journal of Chinese Medicine, Vol. 36, No. 5, 967–980.

 

[thescience]

Does anyone know where to find this?Cordysterone™-Yongyi

the company appears to be based in canada. while i see the product listed in their lineup on the page you provided, it is not listed on their homepage i found in my own research, though they have a phone number listed. the ad seems to suggest the supplement only contains that one component of corycepts, which sounds cool, but no label or dose is presented so i dont know how for sure different it is from taking cordyceps powder straight up, which goes for 30$ a pound and is 10% cordysterone.

 

[tyrub42]

Have you tried cordyceps before? If not, just start with a cheap bulk extract, or you could get this for a bit more http://www.nutraplanet.com/product/millennium-sport-technologies/ultra-cordygen-v02-120-v02-caps.html which has good reviews.

I have 100g of bulk waiting to be taken when I get a chance and I am excited. I don't think people report much from it regarding strength gains or testosterone increase like that website you linked said. I think it is mostly an endurance/health supplement. It has great reviews for those purposes, though.

 

[xhrr]

If you are going to purchase a cordyceps product stick with MST