Forskolin-95 GI distress

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  1. Quote Originally Posted by Johnston View Post
    Anyone else experienced this? This is on Synthetic Supplements' Forskolin-95. I did read other less reputable brands had this side effect. I'm on 100mg daily (x2 morning, x2 pre-workout), only been on it a week, and it's not pleasant, proper Hershey Squirts lol. Should I dial back dosage, or am I just a bad responder to this stuff? Anything else I could take to alleviate this problem?
    I have rank gas when I take foreskolin but I've never been a fire hydrant of Hershey squirts
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  2. rank gas

    Excellent
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  3. Well I read somewhere that due to the way Forskolin works, it reacts in such a way in the small intestine that means this side effect can be quite common (something to do with membrane permanent cAMP I think), so it's not a negative as much as a normal reaction, and you're lucky if you DON'T get it. Not sure if this is true or not though.

  4. ....Be careful while doing squats!.

  5. Quote Originally Posted by Johnston View Post
    Well I read somewhere that due to the way Forskolin works, it reacts in such a way in the small intestine that means this side effect can be quite common (something to do with membrane permanent cAMP I think), so it's not a negative as much as a normal reaction, and you're lucky if you DON'T get it. Not sure if this is true or not though.
    GI issues and Forsk have long been common, it isn't really a new supplement that no one has had trouble running. 95% is supposed to be nicer on the GI sides than the lower extract versions, but I have limited experience with taking a bunch of different extract amounts. Like anything else it's very user dependent.
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  6. I'm nearing 12 weeks @100mg/day...no gi issues that I recall...possible increase in hair shedding though...? Anyone else experience that?

  7. Quote Originally Posted by Geoforce View Post
    95% is supposed to be nicer on the GI sides than the lower extract versions,
    Completely false. The higher % forskolin, the more likely GI effects will occur.

    If a 95% forskolin extract does not cause increased motility/diarrhea, then it is bunk.

  8. Be careful what you squirt for.
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  9. Quote Originally Posted by T-Bone View Post
    ....Be careful while doing squats!.
    Be careful while you Twerk

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  10. He's a squirter

  11. Quote Originally Posted by lronFist View Post
    Completely false. The higher % forskolin, the more likely GI effects will occur.

    If a 95% forskolin extract does not cause increased motility/diarrhea, then it is bunk.
    Hey I don't make the supplement nor the claims. As I said it's supposed (as in it's marketed) to be less than other extracts, but I put in my post I had limited experience with forsk and various extracts. I was only posting what is said about it, not my experience. I don't have enough personal experience with other extract percentages to say this is what I've noticed. AS 95% is pretty much all I've personally used.

    Do you have evidence for your post?
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  12. Quote Originally Posted by lronFist View Post

    Completely false. The higher % forskolin, the more likely GI effects will occur.

    If a 95% forskolin extract does not cause increased motility/diarrhea, then it is bunk.
    From what I have read you are incorrect in this regard

  13. Quote Originally Posted by Geoforce View Post
    Do you have evidence for your post?
    We know exactly how forskolin produces diarrhea in the GI tract: it binds to adenylyl cyclase and dumps chloride ions into the lumen. The ions draw water producing an ismotic effect in the same way as Cholera.

    There is no mystery.

    Anyone who claims otherwise is mistaken.

  14. Ironfist is quite right about the MOA by which forskolin can induce diarrhea. Anecdotally speaking, I think most would agree that an equivalent dose of forskolin, ingested as a low % extract vs a high % extract, produces different degrees of GI distress. This would most plausibly be due to other components found within the plant...the root is usually the specific site of extraction:

    http://www.ncbi.nlm.nih.gov/pubmed/16468372

    For more general info on forskolin's array of effects, here is a nice review:

    http://www.altmedrev.com/publications/11/1/47.pdf

  15. Quote Originally Posted by mr.cooper69 View Post
    Ironfist is quite right about the MOA by which forskolin can induce diarrhea. Anecdotally speaking, I think most would agree that an equivalent dose of forskolin, ingested as a low % extract vs a high % extract, produces different degrees of GI distress. This would most plausibly be due to other components found within the plant...the root is usually the specific site of extraction:

    http://www.ncbi.nlm.nih.gov/pubmed/16468372

    For more general info on forskolin's array of effects, here is a nice review:

    http://www.altmedrev.com/publications/11/1/47.pdf
    Your post confuses me Coop. This is from the description of F-95.

    Other extracts are typically 10-40% pure and bring along many complaints of indigestion and nauseua. We welcome those people to see why 95% pure is the best on the market.
    The MOA is correct, but is IF correct when saying the higher extract should increase problems and not decrease them. If so the description of F-95 may need tweaked.
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  16. Quote Originally Posted by Geoforce View Post
    Your post confuses me Coop. This is from the description of F-95.



    The MOA is correct, but is IF correct when saying the higher extract should increase problems and not decrease them. If so the description of F-95 may need tweaked.
    You're misunderstanding me completely. The higher extract would increase GI issues? Not even Ironfist is saying that...

    Forksolin possesses the inherent capability to cause GI issues. The extract % is irrelevant here; the dose is what counts. However, exactly as the writeup says, people generally notice more GI issues with lower % extracts at equivalent forskolin doses. Since the only variation between a high and low % extract is the extra constituents of a lower % extract, the issue likely lies there (do some research on the compounds in the paper I posted).

  17. Quote Originally Posted by mr.cooper69 View Post
    You're misunderstanding me completely. The higher extract would increase GI issues? Not even Ironfist is saying that...

    Forksolin possesses the inherent capability to cause GI issues. The extract % is irrelevant here; the dose is what counts. However, exactly as the writeup says, people generally notice more GI issues with lower % extracts at equivalent forskolin doses. Since the only variation between a high and low % extract is the extra constituents of a lower % extract, the issue likely lies there (do some research on the compounds in the paper I posted).
    Isn't IronFist saying exactly that? He was responding to my original post of the higher extract should see less GI distress.

    Quote Originally Posted by lronFist View Post
    Completely false. The higher % forskolin, the more likely GI effects will occur.

    If a 95% forskolin extract does not cause increased motility/diarrhea, then it is bunk.
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  18. Quote Originally Posted by Geoforce View Post
    Isn't IronFist saying exactly that? He was responding to my original post of the higher extract should see less GI distress.
    I know what he's trying to say, and that is that more forskolin = more GI issues. It is dose-dependent, not extract %-dependent, and I'm fairly certain he's just saying that a higher extract % will yield a higher dose of forskolin at an equivalent extract dose. In essence, he is saying that if you take equivalent doses of forskolin extracts, the one with the higher % forskolin will elicit more GI issues. Aka 500mg of 95% extract will cause more GI issues than 500mg of 20% extract. These are equivalent extract doses.

    I am saying that based on the experiences of most forskolin users, 50mg of forskolin from 95% extract will yield less GI issues than 50mg of forskolin from a 20% extract. These are equivalent forskolin doses. I hope that's clear enough

  19. Neither theory fits my own exp. ha When I use lower % I tend to have bad cramps the first and sometimes second days(stomach feels like its in knots),however with higher % I just have general diarrhea for several week - not terrible , but consistant loose stools for the run

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  20. Quote Originally Posted by mr.cooper69 View Post
    Ironfist is quite right about the MOA by which forskolin can induce diarrhea. Anecdotally speaking, I think most would agree that an equivalent dose of forskolin, ingested as a low % extract vs a high % extract, produces different degrees of GI distress. This would most plausibly be due to other components found within the plant...the root is usually the specific site of extraction:

    http://www.ncbi.nlm.nih.gov/pubmed/16468372

    For more general info on forskolin's array of effects, here is a nice review:

    http://www.altmedrev.com/publications/11/1/47.pdf
    Wow - especially the 2nd review. Thank you.

  21. So if I'm not getting GI distress from the forskolin 95 I should up my dose?. I'm already taking 150mg per day. Confused.

  22. Quote Originally Posted by lronFist View Post

    If a 95% forskolin extract does not cause increased motility/diarrhea, then it is bunk.

    So...I'm just confused about this statement.

  23. Your dose is fine. The forskolin isn't bunk, it's from Sabinsa. His statement was hyperbole. Many people will never get GI issues from forskolin for a variety of reasons (other supplements that slow GI motility, a genetically hypokinetic GI tract, etc)

  24. Quote Originally Posted by Johnston View Post
    Yeah, I read that was the optimal way to take it... but if it's going to cause me upset, then clearly I'm going to get upset the worst this way.
    Let me know if you find something that works. I have tried dosing it every which way and it does not seem to reduce GI distress....thanks.

  25. I don't get any GI issues with Forskolin 95, but sometimes when I take it (usually on weekends for some reason) it makes my resting heart rate increase by about 15 bpm and my pulse gets stronger, sometimes to the point where I can actually see my chest or upper abdomen move. It's actually rather unpleasant, and that's with only one cap a day.

  26. Quote Originally Posted by Spindletop View Post
    I don't get any GI issues with Forskolin 95, but sometimes when I take it (usually on weekends for some reason) it makes my resting heart rate increase by about 15 bpm and my pulse gets stronger, sometimes to the point where I can actually see my chest or upper abdomen move. It's actually rather unpleasant, and that's with only one cap a day.
    Yeah, forskolin is a positive inotrope, which is actually a good thing (improves cardiac function) while also acting as a vasodilator. The net effect would be an increase in systolic BP but a drop in diastolic BP, and an overall improved cardiovascular profile.
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    Quote Originally Posted by mr.cooper69 View Post

    Yeah, forskolin is a positive inotrope, which is actually a good thing (improves cardiac function) while also acting as a vasodilator. The net effect would be an increase in systolic BP but a drop in diastolic BP, and an overall improved cardiovascular profile.
    The more you teach me about Forskolin the more I am glad I loaded up on the AS sale
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  28. Quote Originally Posted by T-Bone View Post
    So...I'm just confused about this statement.
    If you do not get the GI symptoms I mentioned earlier, then you are not consuming genuine forskolin. It's a pretty reliable litmus test, as forskolin has been used for decades as an artificial means of mimicking diarrhea-causing pathogens.

    http://jn.nutrition.org/content/135/10/2320.long
    http://clincancerres.aacrjournals.or...t/7/2/343.long
    http://www.ncbi.nlm.nih.gov/pubmed/16112134
    http://www.ncbi.nlm.nih.gov/pubmed/16061885
    http://www.ncbi.nlm.nih.gov/pubmed/16614995
    http://www.ncbi.nlm.nih.gov/pubmed/2311974
    http://www.ncbi.nlm.nih.gov/pubmed/16495521
    http://www.ncbi.nlm.nih.gov/pubmed/14684576
    http://www.ncbi.nlm.nih.gov/pubmed/16455334
    http://www.ncbi.nlm.nih.gov/pubmed/1329520

    et cetra

  29. neuron, you of all people know that not everyone will get GI issues at the same dose. Diarrhea may be a litmus test, but I wouldn't call it "reliable" unless we are controlling for dose, GI motility, etc.

    Even the human trials on forskolin for fat loss note that some users experienced GI upset while others didn't.

  30. My GI tract also doesn't necessarily work normally. I have had irritable bowel syndrome for 20 years.
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