dosing - p5p and na r ala

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    dosing - p5p and na r ala


    Started taking these two supps recently, but not sure about what the typical dosing should be. Bottle of p5p says to take one 50mg capsule daily, and the r ala is 100mg caps and it says to take 1-2 daily. I'm taking p5p for prolactin (running LMG right now), and just heard a lot of good things about r ala. Should I just go by the labels on these - are those effective doses?

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    I'm not to sure about the p5p but I currently take 200mg r-ala in the morning followed by a second dose later in the day (before two largest carb containing meals).
    I have seen ppl take 300mg 2 times a day but I personally did not see any extra benefit of the increased dose except for a lighter wallet lol
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    300mg na-r-ala daily with your highest carb meal(s)
    P5P with food
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES
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    Quote Originally Posted by mr.cooper69 View Post
    300mg na-r-ala daily with your highest carb meal(s) P5P with food
    It has a half life of 12 hours right?

    One dosage with biggest carb meal. It's still effective later on with others when carbs are taken correct? Basically no need to take twice per day?
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    Quote Originally Posted by halfhuman View Post
    It has a half life of 12 hours right?

    One dosage with biggest carb meal. It's still effective later on with others when carbs are taken correct? Basically no need to take twice per day?
    Right
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    Better options than P5P for PRL control
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    Quote Originally Posted by hyperCat View Post
    Started taking these two supps recently, but not sure about what the typical dosing should be. Bottle of p5p says to take one 50mg capsule daily, and the r ala is 100mg caps and it says to take 1-2 daily. I'm taking p5p for prolactin (running LMG right now), and just heard a lot of good things about r ala. Should I just go by the labels on these - are those effective doses?
    INHIBIT P would be a better choice for prolactin control. Its usually less than $19 a bottle

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    Quote Originally Posted by mr.cooper69 View Post
    300mg na-r-ala daily with your highest carb meal(s)
    P5P with food
    How much p5p is generally recommended?
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    Quote Originally Posted by mw1 View Post
    INHIBIT P would be a better choice for prolactin control. Its usually less than $19 a bottle
    Not really, dosing L-Dopa and P5P together tends to be counterproductive
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    Interesting. First time I have ever heard of this

    You got any proof?

    Thanks

    Quote Originally Posted by Diesel0022 View Post
    Not really, dosing L-Dopa and P5P together tends to be counterproductive
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    Quote Originally Posted by Whacked View Post
    Interesting. First time I have ever heard of this

    You got any proof?

    Thanks
    Inhibit P would be good stacked with a decarboxylase inhibitor, still a wiser choice to buy bulk ingredients (Dopadex/P5P) and a decarboxylase inhibitor, in regards to both money saved and "quality" (higher percentage L-Dopa). Not to mention at 300mg Vitex is essentially moot.

    Inhibition of l-Dopa-Induced Growth Hormone Stimulation by Pyridoxine and Chlorpromazine

    Abstract

    One gram of l-dopa was administered orally to 12 male control subjects and induced an increase of growth hormone (GH) secretion. The l-dopa-induced GH response was inhibited by an intravenous infusion of pyridoxine, but pyridoxine did not inhibit the GH response to hypoglycemia. Chlorpromazine also inhibited l-dopa-induced GH stimulation. Glucose concentrations were unaffected by l-dopa, chlorpromazine, and pyridoxine administration in these subjects. The mechanism of the suppressed l-dopa-induced GH response by pyridoxine appears to be mediated by peripheral acceleration of the conversion of l-dopa to dopamine, while that of chlorpromazine appears to be mediated through hypothalamic centers. Pyridoxine and chlorpromazine should be added to the list of other factors affecting the response to L-dopa-induced GH stimulation.




    Failure of vitamin B6 to reverse the l-dopa effect in patients on a dopa decarboxylase inhibitor

    Abstract

    Seven patients with Parkinsonism previously on l-dopa were placed on a regimen of l-dopa and alpha methyl dopa hydrazine (a dopa decarboxylase inhibitor). Two of these patients had previously shown marked clinical deterioration of the l-dopa improvement when given pyridoxine. None of the seven patients receiving alpha methyl dopa hydrazine demonstrated any change in their condition when given pyridoxine. The failure of vitamin B6 to reverse the clinical effect of l-dopa in patients receiving both l-dopa and a peripheral dopa decarboxylase inhibitor suggests that reversal of the l-dopa effect induced by vitamin B6 is due to increasing the activity of the enzyme dopa decarboxylase outside the central nervous system.




    ON THE MECHANISM OF THE NULLIFICATION OF CNS EFFECTS OF l-DOPA BY PYRIDOXINE IN PARKINSONIAN PATIENTS


    Abstract

    Administration of either Levodopa (l-DOPA) or pyridoxine increased the concentration of dopamine in the basal ganglia of rats. However, administration of pyridoxine to rats pretreated with l-DOPA for several days resulted in a reversal of the l-DOPA-induced elevation of dopamine. Pretreatment of rats with Ro 4-4602 (an inhibitor of peripheral aromatic amino acid decarboxylases) enhanced the l-DOPA-induced rise in the CNS level of dopamine. This effect was also reduced substantially after the administration of pyridoxine. We interpret these results to indicate that the antagonistic effect of pyridoxine on the beneficial effects of l-DOPA in the CNS is centrally mediated as a result of decreased formation of dopamine.
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    Quote Originally Posted by Diesel0022 View Post
    Not really, dosing L-Dopa and P5P together tends to be counterproductive
    I think a lot of that was debated in this thread:
    Inhibit-P SNS

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    Quote Originally Posted by mw1 View Post
    I think a lot of that was debated in this thread:
    Inhibit-P SNS

    Dosing P5P and Mucuna increases Dopamine conversion outside the BBB by a much larger amount (more blood outside the brain than inside) so the net effect is negative.

    You're better off either dosing them separately, or using another supplement to control PRL.

    Now, a post from another board.

    Quote Originally Posted by Diesel0022 View Post
    Alright, I am going to quote Cy word for word from the text messages

    It started on here, he stated that he "preferred dopadex", when compared to L-Dopa/P5P together.

    And straight from the text messages "Using l-dopa with p5p is not optimal"


    I confirmed with him before I posted this to make sure it was ok


    Now for the complications. (Aren't there always complications
    in life?) The final reaction to the neurotransmitter in both the
    case of dopamine and serotonin, is decarboxylation, and the same
    enzyme (the aromatic L-amino acid decarboxylase) is involved in
    both conversions. This decarboxylase enzyme is present in the
    liver, and it acts in the case of L-DOPA to convert the compound
    to dopamine before it can make it into the brain (and if this
    happens, the L-DOPA is wasted). The decarboxylase enzyme uses B6
    as a cofactor for this reaction, and for this reason a
    Parkinson's disease patient taking L-DOPA cannot take more than
    the RDA of B6, because doing so would act to neutralize
    oral L-DOPA too quickly. These days, almost all Parkinson's
    patients on L-DOPA take the drug in a combination with an
    artificial decarboxylase inhibitor, called Carbidopa (the
    combination is called Sinemet). But even with Carbidopa,
    Parkinson's patients are advised not to exceed a daily dose of B6
    of 25 mg, since more will overwhelm the Carbidopa effect, and
    cause pharmacologic L-DOPA to be destroyed in the liver before it
    can get into the brain.
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    Quote Originally Posted by Diesel0022 View Post

    Not really, dosing L-Dopa and P5P together tends to be counterproductive
    It isn't significant. Inhibit p works well.
    Do you know of any studies done with oral administration.

    If it only contained a small amount of muca, and a large amount of p5p, it might make a difference.

    But it's the opposite. And it also has vitex.
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    Quote Originally Posted by jbryand101b View Post
    It isn't significant. Inhibit p works well.

    If it only contained a small amount of muca, and a large amount of p5p, it might make a difference.

    But it's the opposite. And it also has vitex.
    It only takes 25mg to "cause pharmacologic L-DOPA to be destroyed in the liver before it can get into the brain. "

    There's really not much of an argument here. Standalone L-Dopa would be superior.
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    Quote Originally Posted by Diesel0022 View Post

    It only takes 25mg to "cause pharmacologic L-DOPA to be destroyed in the liver before it can get into the brain. "

    There's really not much of an argument here. Standalone L-Dopa would be superior.
    Also, do you have info on prolactin effects? Cause those studies are referring to gh responce.
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    Quote Originally Posted by jbryand101b View Post
    Also, do you have info on prolactin effects? Cause those studies are referring to gh responce.
    That's egregiously irrelevant. All 3 came to the conclusion that dosing B6 alongside L-Dopa increases conversion outside the BBB. Same MOA for PRL control/reduction.

    Stop while you're ahead.
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    One human study showed a single 300mg dosage of B6 exerts 'a hypothalamic dopaminergic effect' which causes a 'significant decrease of plasma prolactin'(1);
    Another found that 300mg of B6 taken twice a day by 10 normal women lowered prolactin levels and slightly but significantly raised growth hormone levels. The authors concluded: 'The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level'(2);
    Another study found B6 to significantly reduce 'opioids-induced hyperprolactinemia'(3); This study on men found that 'Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise'(4);
    And a study on male rats found that, 'Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01)'(5).

    (1)http://www.ncbi.nlm.nih.gov/pubmed/1254699
    (2)http://www.ncbi.nlm.nih.gov/pubmed/6324828
    (3)http://www.ncbi.nlm.nih.gov/pubmed/3967846
    (4)http://www.ncbi.nlm.nih.gov/pubmed/7088124
    (5)http://www.ncbi.nlm.nih.gov/pubmed/501547
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    Quote Originally Posted by jbryand101b View Post
    One human study showed a single 300mg dosage of B6 exerts 'a hypothalamic dopaminergic effect' which causes a 'significant decrease of plasma prolactin'(1);
    Another found that 300mg of B6 taken twice a day by 10 normal women lowered prolactin levels and slightly but significantly raised growth hormone levels. The authors concluded: 'The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level'(2);
    Another study found B6 to significantly reduce 'opioids-induced hyperprolactinemia'(3); This study on men found that 'Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise'(4);
    And a study on male rats found that, 'Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01)'(5).
    That's not even remotely relevant. And please quote the source where you copy and paste from.

    I'm sure Ed Clements would not appreciate you parroting his articles.
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    Quote Originally Posted by Diesel0022 View Post

    That's not even remotely relevant. And please quote the source where you copy and paste from.
    Recheck

    And op is looking for a prolactin inhibition responce, not growth hormone.

    I'm sure ed doesn't have a problem.

    I'm on my phone, and can only c n p so much. You respond too fast.
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    Quote Originally Posted by jbryand101b View Post
    Recheck

    And op is looking for a prolactin inhibition responce, not growth hormone.
    I don't see how dosing P5P alone is relevant to P5P+L-Dopa

    I'm getting the feeling you are not versed on this subject.
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    Quote Originally Posted by Diesel0022 View Post

    I don't see how dosing P5P alone is relevant to P5P+L-Dopa
    You have oral administration not intravenous, you also have vitex, brb

    Looking for studies to show p5p combined with muca puriens, and all 3 including vitex are counterproductive, for inhibition of prolactin.

    But unable to find any. If you know of any using oral administration, please share.

    However, anecdotally, user feedback has been overwhelmingly positive.
    I even use inhibit p myself. Doesn't say much though cause I'm a Sns rep. But I don't push products from anyone I don't use, even Sns.
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    Quote Originally Posted by Whacked View Post
    Interesting. First time I have ever heard of this

    You got any proof?

    Thanks
    Have read that a lot of times also
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    Quote Originally Posted by Diesel0022 View Post
    Inhibit P would be good stacked with a decarboxylase inhibitor, still a wiser choice to buy bulk ingredients (Dopadex/P5P) and a decarboxylase inhibitor, in regards to both money saved and "quality" (higher percentage L-Dopa). Not to mention at 300mg Vitex is essentially moot.
    Please excuse my ignorance (thus, this question) but can you suggest a herbal or other non-prescription decarboxylase inhibitor?
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    Quote Originally Posted by Beau View Post
    Please excuse my ignorance (thus, this question) but can you suggest a herbal or other non-prescription decarboxylase inhibitor?
    I believe green tea caps will do the trick. could be wrong though.



    http://www.nutraplanet.com/product/s...-capsules.html

    10 bucks.
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    Quote Originally Posted by jbryand101b View Post
    I believe green tea caps will do the trick. could be wrong though.

    [img]http://www.seriousnutritionsolutions. com/img/products/Green-Tea.png[/mg]

    http://www.nutraplanet.com/product/s...-capsules.html



    10 bucks.
    Only at very high dosages, ~5G
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    Quote Originally Posted by Diesel0022 View Post
    Only at very high dosages, ~5G
    I will look at see if anyone offers an extract; say 4:1.
  

  
 

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