a good quick read on Agmatine

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    a good quick read on Agmatine


    Agmatine [4-(aminobutyl)guanidine], an endogenous neurotransmitter [1], is decarboxylated L-arginine and is a metabolic product of mammalian cells. Agmatine binds to α2-adrenergic receptor, it induces the release of some peptide hormones, and was reported to inhibit nitric oxide synthase (nitric oxide synthases are responsible for the production of nitric oxide from L-arginine) [1,2]. Agmatine benefits for exercise

    There are many claimed benefits of agmatine and a lot of disinformation is circling all over internet. Some even claim that agmatine increases nitric oxide production via inhibition of nitric oxide synthase enzyme, which is nonsense. A study by Elena Galea and others [2] reported that agmatine is a competitive inhibitor of all nitric oxide synthase isoenzymes. However, it seems that agmatine stimulates some types of nitric oxide synthase while inhibiting others. Morrissey and Klahr [3] reported that agmatine caused activation of nitric oxide synthase in endothelial cells (layer of cells on inner surface of blood vessels). Agmatine appears to act directly on endothelial cells to increase the synthesis of nitric oxide, which induces them to cause vasodilatation [3].
    Agmatine has potential to treat chronic pain, addictive states and brain injury due to its ability to inhibit hyperalgesia (increased sensitivity to pain) and its neuroprotective activity [4]. Therefore it may potentiate the effects of analgesics used during recovery from injury. Feyza Aricioglu and Hale Altunbas [5] reported modulatory effect of agmatine on anxiety and depression. Accumulating evidence suggests that agmatine possesses nootropic effects and that is a novel neurotransmitter [6]. More and more evidence is accumulating on the involvement of agmatine in the processes of learning and memory, however, direct evidence of its involvement is currently lacking [6].
    In vitro studies are also showing insulin-like effect [7]. Sener A. et al. [8] have shown that agmatine causes stimulation of insulin secretion but fails to affect insulin release in the absence of glucose.



    References

    1. Feng, Yangzheng, John E. Piletz, and Michael H. Leblanc. “Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats.” Pediatric research 52.4 (2002): 606-611.
    2. Galea, Elena, et al. “Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine.” Biochem. J 316 (1996): 247-249.
    3. Morrissey, Jeremiah J., and Saulo Klahr. “Agmatine activation of nitric oxide synthase in endothelial cells.” Proceedings of the Association of American Physicians 109.1 (1997): 51-57.
    4. Reis, Donald J., and Soundararajan Regunathan. “Is agmatine a novel neurotransmitter in brain?.” Trends in pharmacological sciences 21.5 (2000): 187-193.
    5. Aricioglu, Feyza, and Hale Altunbas. “Is agmatine an endogenous anxiolytic/antidepressant agent?.” Annals of the New York Academy of sciences 1009.1 (2003): 136-140.
    6. Liu, Ping, et al. “Spatial learning results in elevated agmatine levels in the rat brain.” Hippocampus 18.11 (2008): 1094-1098.
    7. Weitzel, Günther, Brigitte Pfeiffer, and Wieland Stock. “Insulin-like partial effects of agmatine derivatives in adipocytes.” Hoppe-Seyler´ s Zeitschrift für physiologische Chemie 361.1 (1980): 51-60.
    8. Sener, Abdullah, et al. “Stimulus-secretion coupling of arginine-induced insulin release: Insulinotro action of agmatine.” Biochemical pharmacology 38.2 (1989): 327-330.





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    Very interesting read!! thanks for posting!! i Just started taking agmatine and have liked what i have seen but i also added 5g of citrulline malate to my preworkout too.
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    Quote Originally Posted by R1balla View Post
    Agmatine [4-(aminobutyl)guanidine], an endogenous neurotransmitter [1], is decarboxylated L-arginine and is a metabolic product of mammalian cells. Agmatine binds to α2-adrenergic receptor, it induces the release of some peptide hormones, and was reported to inhibit nitric oxide synthase (nitric oxide synthases are responsible for the production of nitric oxide from L-arginine) [1,2]. Agmatine benefits for exercise

    There are many claimed benefits of agmatine and a lot of disinformation is circling all over internet. Some even claim that agmatine increases nitric oxide production via inhibition of nitric oxide synthase enzyme, which is nonsense. A study by Elena Galea and others [2] reported that agmatine is a competitive inhibitor of all nitric oxide synthase isoenzymes. However, it seems that agmatine stimulates some types of nitric oxide synthase while inhibiting others. Morrissey and Klahr [3] reported that agmatine caused activation of nitric oxide synthase in endothelial cells (layer of cells on inner surface of blood vessels). Agmatine appears to act directly on endothelial cells to increase the synthesis of nitric oxide, which induces them to cause vasodilatation [3].
    Agmatine has potential to treat chronic pain, addictive states and brain injury due to its ability to inhibit hyperalgesia (increased sensitivity to pain) and its neuroprotective activity [4]. Therefore it may potentiate the effects of analgesics used during recovery from injury. Feyza Aricioglu and Hale Altunbas [5] reported modulatory effect of agmatine on anxiety and depression. Accumulating evidence suggests that agmatine possesses nootropic effects and that is a novel neurotransmitter [6]. More and more evidence is accumulating on the involvement of agmatine in the processes of learning and memory, however, direct evidence of its involvement is currently lacking [6].
    In vitro studies are also showing insulin-like effect [7]. Sener A. et al. [8] have shown that agmatine causes stimulation of insulin secretion but fails to affect insulin release in the absence of glucose.



    References

    1. Feng, Yangzheng, John E. Piletz, and Michael H. Leblanc. “Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats.” Pediatric research 52.4 (2002): 606-611.
    2. Galea, Elena, et al. “Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine.” Biochem. J 316 (1996): 247-249.
    3. Morrissey, Jeremiah J., and Saulo Klahr. “Agmatine activation of nitric oxide synthase in endothelial cells.” Proceedings of the Association of American Physicians 109.1 (1997): 51-57.
    4. Reis, Donald J., and Soundararajan Regunathan. “Is agmatine a novel neurotransmitter in brain?.” Trends in pharmacological sciences 21.5 (2000): 187-193.
    5. Aricioglu, Feyza, and Hale Altunbas. “Is agmatine an endogenous anxiolytic/antidepressant agent?.” Annals of the New York Academy of sciences 1009.1 (2003): 136-140.
    6. Liu, Ping, et al. “Spatial learning results in elevated agmatine levels in the rat brain.” Hippocampus 18.11 (2008): 1094-1098.
    7. Weitzel, Günther, Brigitte Pfeiffer, and Wieland Stock. “Insulin-like partial effects of agmatine derivatives in adipocytes.” Hoppe-Seyler´ s Zeitschrift für physiologische Chemie 361.1 (1980): 51-60.
    8. Sener, Abdullah, et al. “Stimulus-secretion coupling of arginine-induced insulin release: Insulinotro action of agmatine.” Biochemical pharmacology 38.2 (1989): 327-330.





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    JK good read thanks R1!
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    Quote Originally Posted by DJBeanPole View Post
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    JK good read thanks R1!


    bahahhahaha
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    Quote Originally Posted by pcowan13 View Post
    Very interesting read!! thanks for posting!! i Just started taking agmatine and have liked what i have seen but i also added 5g of citrulline malate to my preworkout too.

    try taking agmatine before bed. its awesome
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    Quote Originally Posted by R1balla View Post
    try taking agmatine before bed. its awesome
    Just better sleep or what?
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    Quote Originally Posted by pcowan13 View Post
    Just better sleep or what?
    I really dont know exactly how it happens. @mr.cooper69 can better explain it but if im not mistaken, it indirectly increases GH levels.
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    so do i take it pre work out and before bed or just before bed?
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    Quote Originally Posted by pcowan13 View Post
    so do i take it pre work out and before bed or just before bed?
    i do 500mg pre workout and 500mg at night
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    Quote Originally Posted by R1balla View Post
    i do 500mg pre workout and 500mg at night
    Yeah, that's generally my protocol with agmatine as well. I like it.
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    awesome info.

    This is why we suggest using our bulk Agmatine powder 50g tubs before meals, pre-workout, and/or pre-bed
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    Quote Originally Posted by VaughnTrue View Post
    awesome info.

    This is why we suggest using our bulk Agmatine powder 50g tubs before meals, pre-workout, and/or pre-bed
    This is why we also suggest our 50g and 100g tubs of Agmatine powder .
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    Spaniard's Corner :P

    Quote Originally Posted by Spaniard View Post
    This is why we also suggest our 50g and 100g tubs of Agmatine powder .
    100 gram tubs? Oooooooooooooo. I know what I'm going for when I run out of my PrimaForce
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    Quote Originally Posted by Spaniard View Post

    This is why we also suggest our 50g and 100g tubs of Agmatine powder .
    Exactly.
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    Very nice to know as I've just started on this as well. So far have only been taking 500mg upon waking. Will add into my before bed routine as well,

    Thanks for the read and the information,
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    Nice read.
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    Has anyone taken agmatine and a GDA pre meal?
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    i do 2g agmatine prework another 1-2(depends on size of scoop) some where during the day and another 2 or so before i sleep

    500mg - one gram does nada for me
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    Quote Originally Posted by Spaniard View Post
    This is why we also suggest our 50g and 100g tubs of Agmatine powder .
    This is why @BioCor .....

    ah nevermind, not worth it lol
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    Quote Originally Posted by halfhuman View Post
    Has anyone taken agmatine and a GDA pre meal?
    I take both glycophase and agmatine before my preworkout meal
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    Quote Originally Posted by halfhuman View Post
    Has anyone taken agmatine and a GDA pre meal?
    I take both glycophase and agmatine before my preworkout meal.
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    Quote Originally Posted by kissdadookie View Post
    Spaniard's Corner :P



    100 gram tubs? Oooooooooooooo. I know what I'm going for when I run out of my PrimaForce
    Spaniard's Arena hell Yea man pick some up 100 days worth at a gram a day

    Quote Originally Posted by R1balla View Post
    This is why @BioCor .....

    ah nevermind, not worth it lol
    Lmao it's always worth it!
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    Quote Originally Posted by VaughnTrue View Post
    awesome info.

    This is why we suggest using our bulk Agmatine powder 50g tubs before meals, pre-workout, and/or pre-bed
    Is it ok to mix bulk Agmatine together with Leucine? I Normally mix 1 gram Agmatine to 3 grams Leucine Pre work out.
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    Quote Originally Posted by ironranger View Post
    Is it ok to mix bulk Agmatine together with Leucine? I Normally mix 1 gram Agmatine to 3 grams Leucine Pre work out.
    Sure thing. But only if its SNS Agmatine, any other brand will spontaneously combust when you shake it.

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    Quote Originally Posted by fightbackhxc View Post
    I take both glycophase and agmatine before my preworkout meal
    Ima try this than. Sounds great and weird no one ever mentioned it.
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    Quote Originally Posted by R1balla View Post
    This is why @BioCor .....

    ah nevermind, not worth it lol




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    Quote Originally Posted by BioCor View Post



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    Quote Originally Posted by Spaniard View Post
    Spaniard's Arena hell Yea man pick some up 100 days worth at a gram a day
    Excellent. Very convenient so that I don't have to keep reordering so frequently
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    Hi again,

    In my research last evening (on the web, lol) I came across a site that gave a lot of pro's and con's on Agmatine. It was a very positive article with links to a lot of research that has been done in different studies, etc. However, one con they mentioned twice was that Agmatine has the capability to negate the blocking properties of Yohimbe.

    Is this something that is well known or not a major deal. I'm going to continue using the Agmatine but I just had that question. Thanks,
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    Quote Originally Posted by cedman1 View Post
    Hi again,

    In my research last evening (on the web, lol) I came across a site that gave a lot of pro's and con's on Agmatine. It was a very positive article with links to a lot of research that has been done in different studies, etc. However, one con they mentioned twice was that Agmatine has the capability to negate the blocking properties of Yohimbe.

    Is this something that is well known or not a major deal. I'm going to continue using the Agmatine but I just had that question. Thanks,
    I've never heard of this and I happen to be using Agmatine and Yohimbine HCL at the moment... In for more info
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    Quote Originally Posted by mtinsideout View Post

    I've never heard of this and I happen to be using Agmatine and Yohimbine HCL at the moment... In for more info
    Agmatine binds but posses no action there actually the intra workout agmatine leucine and yohimbine with 15-30g carbs will produce mind boggling pumps add in a few othe key ingredients and it's anabolism all day
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    Quote Originally Posted by EBF Inc View Post
    Agmatine binds but posses no action there actually the intra workout agmatine leucine and yohimbine with 15-30g carbs will produce mind boggling pumps add in a few othe key ingredients and it's anabolism all day
    You didn't english to well there lol... I know agmatine+cit mal+BA+creatine+green tea+caffeine+yohimbine+DMAA+po wder gatorade=F'ing epic gym time... But is there anything wrong with this combo??
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    Quote Originally Posted by EBF Inc View Post
    Agmatine binds but posses no action there actually the intra workout agmatine leucine and yohimbine with 15-30g carbs will produce mind boggling pumps add in a few othe key ingredients and it's anabolism all day
    I've always wondered what yohimbine's effects on pumps was. Anybody care to explain? Does it have bloodflow promoting qualities?
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    Quote Originally Posted by cedman1 View Post
    Hi again,

    In my research last evening (on the web, lol) I came across a site that gave a lot of pro's and con's on Agmatine. It was a very positive article with links to a lot of research that has been done in different studies, etc. However, one con they mentioned twice was that Agmatine has the capability to negate the blocking properties of Yohimbe.

    Is this something that is well known or not a major deal. I'm going to continue using the Agmatine but I just had that question. Thanks,

    would you care to post those studies on here or PM me the links and I will post them?
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    Quote Originally Posted by R1balla View Post
    would you care to post those studies on here or PM me the links and I will post them?

    Sure as this is the first I've seen of this listed con:

    *taken from Link*
    Does Not Go Well With

    L-Arginine and L-Citrulline (for some neurological effects; cardiovascular interactions not well elucidated)
    Yohimbine and Rauwolscine (Agmatine activates the α2A receptor that these inhibit)
    D-Aspartic Acid due to reducing signalling via the NMDA receptors
    Alcohol coingestion (may increase ulceration from alcohol)

    Link:
    http://examine.com/supplements/Agmatine/
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    I posted a large thread on this back in 2012 called iirc

    Agmatine food for thought
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    Quote Originally Posted by EBF Inc View Post
    I posted a large thread on this back in 2012 called iirc

    Agmatine food for thought
    OK, will find it and go through that thread as well.

    Thanks

    *** Thanks for posting the link, great info in regards to what I mentioned ***
    Last edited by cedman1; 09-25-2013 at 12:52 PM. Reason: updating
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    Will read when I get home. Thanks for the links guys!!!
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    Quote Originally Posted by Jiigzz View Post
    Sure thing. But only if its SNS Agmatine, any other brand will spontaneously combust when you shake it.

    Sounds like fun, will have to try that lol, new I should have purchased SNS
  

  
 

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