Coop's Corner #4: Alpha-2 Antagonism? Yes Please.

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  1. Quote Originally Posted by lpfleiderer View Post
    Sorry if this seems like its off topic, and if I'm still very new to AM. Trying to learn as much as possible.

    Hey coop and anyone else with input, I take a "wakefulness aid" called modafinil to keep me awake most days, its hard staying awake while working 40-50 hrs a week and taking 15 credit hours in college. Yesterday I took my Modafinil and an hour later mixed a scoop of OEP powder(which has Yohimbine in it.). I only drank half of what I mixed, then my energy was out of control. I rode my bike 20 miles in record time. this made me very curious. I was reading up on modafinil and it said: "Modafinil has central alpha 1-adrenergic agonist effects i.e. it directly stimulates the receptors." http://modafinil.com/ 3rd paragraph down. My question is, is it synergistic? or the opposite? would it be is it safe to mix the two?! not asking for medical advice or trying to have you guys answer as a medical professional, just trying to learn if mixing an alpha 1-adrenergic agonist with an alpha-2 antagonist would have an effect on each other. Just here to learn. Thanks -Luke
    An alpha 1 agonist would promote wakefulness, but yohimbine hcl has very little affinity for the alpha 1 receptor (wherein it would antagonize it and create a subtractive effect). Modafinil in general is not fully understood and I wouldn't combine any supplement with it. I also don't recommend using modafinil simply because you have a heavy workload, for financial reasons and otherwise. Caffeine is plenty effective and actually very healthy, neurologically speaking


  2. Coop. I tried messaging you on an idea for coopers corner
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  3. Quote Originally Posted by mr.cooper69 View Post
    Thanks everyone.

    Unfortunately, some users will experience these effects from alpha-2 antagonists due to excessive adrenergic stimulation. It won't matter which alpha-2 antagonist you use, the story will be the same. Your only real hope is the tolerance that develops with continued use. There's evidence that the adrenergic effects diminish with time while lipolysis actually stays constant
    I'm just curious, is the dosing scheme like beta-antagonists, 3weeks on, then 3weeks off because of receptor down regulation? If so, how could I build a tolerance to the adrenergic effect and be on it long enough for significant fat loss?
    William Llewellyn's Anabolics, Underground Anabolics, and SSRG ebook editions!
  4. smoker145
    smoker145's Avatar

    Thread is gold.

  5. Quote Originally Posted by Patuba View Post
    I'm just curious, is the dosing scheme like beta-antagonists, 3weeks on, then 3weeks off because of receptor down regulation? If so, how could I build a tolerance to the adrenergic effect and be on it long enough for significant fat loss?
    This applies to virtually no beta agonists outside of clen (due to the multi-day halflife). Yohimbine has shown a diminished side effect profile with continued lipolysis with prolonged use, similar to ephedrine (a beta agonist).
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  6. What about Boerhaavia diffusa and its effect on the alpha-2 receptor?

  7. Quote Originally Posted by nattydisaster View Post

    It sounds like you just generally have a very low tolerance to a2-antagonists. Like said in this thread, check to see what else you are supplementing with. Anything with tyrosine or tyramine? Are you eating a lot of cheese?
    Nothing else besides creatine, especially on the days I took the yohimbe products. And no, I don't eat lots of cheese. I think I'm just sensitive. No big deal, and again, thanks for providing samples so I could test it in advance.

  8. So after using enhanced since the day it came out for 2-3 days a week, you think I should try alphamine again?. Alphamine always made me jittery/nervous, even at .25 dosage.

  9. Quote Originally Posted by mr.cooper69 View Post
    This applies to virtually no beta agonists outside of clen (due to the multi-day halflife). Yohimbine has shown a diminished side effect profile with continued lipolysis with prolonged use, similar to ephedrine (a beta agonist).
    Whats the longest you would advise taking a yohimbine product? EC stack? ECY stack?

  10. Quote Originally Posted by T-Bone View Post
    So after using enhanced since the day it came out for 2-3 days a week, you think I should try alphamine again?. Alphamine always made me jittery/nervous, even at .25 dosage.
    Different extracts for different purposes
    Quote Originally Posted by McBurly View Post
    Whats the longest you would advise taking a yohimbine product? EC stack? ECY stack?
    I'd say a max of 8 weeks for yohimbine. EC safety studies go up to 6 months

  11. Quote Originally Posted by mr.cooper69 View Post

    This applies to virtually no beta agonists outside of clen (due to the multi-day halflife). Yohimbine has shown a diminished side effect profile with continued lipolysis with prolonged use, similar to ephedrine (a beta agonist).
    Ive noticed the longer I use yohimbe consistently the less I feel jittery. But the rate of fat loss continues

  12. Coop any potential dangers in light alcohol consumption, specifically red wine a few hours after dosing yohimbe? Any interaction with the alcohol or sulfites?

  13. Quote Originally Posted by Clemenza View Post
    Coop any potential dangers in light alcohol consumption, specifically red wine a few hours after dosing yohimbe? Any interaction with the alcohol or sulfites?
    Alcohol, as an activator of AMPK, may potentiate the fat loss effects of yohimbe (in the absence of any other macronutrients)

  14. Quote Originally Posted by mr.cooper69 View Post

    Alcohol, as an activator of AMPK, may potentiate the fat loss effects of yohimbe (in the absence of any other macronutrients)
    I'll be adding a few shots of Jameson to my pre AM cardio Alphamine

  15. Quote Originally Posted by mr.cooper69 View Post

    Alcohol, as an activator of AMPK, may potentiate the fat loss effects of yohimbe (in the absence of any other macronutrients)
    Bam. Time to drink my captain

  16. Quote Originally Posted by Clemenza View Post
    I'll be adding a few shots of Jameson to my pre AM cardio Alphamine
    Fasted, drunk cardio.

    Definitely inspiration for my next YouTube video. Should be hilarious.
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  17. Sweet thread Coop
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
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  18. Quote Originally Posted by bdcc View Post

    Fasted, drunk cardio.

    Definitely inspiration for my next YouTube video. Should be hilarious.
    Vids or its not real
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  19. So far I've learned a ton from all Coop's Corner threads. Please keep it up!

  20. what would be considered 'higher than yohimbine' dosages for the rauwolscine?

  21. Quote Originally Posted by googlealchemi View Post
    what would be considered 'higher than yohimbine' dosages for the rauwolscine?
    Wondering about this myself . I have a few bottles of AlphaBurn from EvoMuse

  22. Quote Originally Posted by dollar662 View Post

    Wondering about this myself . I have a few bottles of AlphaBurn from EvoMuse
    3x the amount

    3mg yohimbine = 9mg alpha y IMO

    Just my preference

  23. Quote Originally Posted by Clemenza View Post
    Coop any potential dangers in light alcohol consumption, specifically red wine a few hours after dosing yohimbe? Any interaction with the alcohol or sulfites?
    What kind of wine do you drink?

    I prefer a shiraz-cabernet blend myself. Pair with some goudad and olives for an appetizer followed by some steak and grilled brussels sprouts... damn now im hungry!
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    "The only good is knowledge and the only evil is ignorance." - Socrates

  24. Is yohimbine okay to take with ECA? If so, and if utilizing the proper eca protocol (25e, 200c, 81a) what would be the proper dose for y?

  25. Quote Originally Posted by The Engineer View Post
    Is yohimbine okay to take with ECA? If so, and if utilizing the proper eca protocol (25e, 200c, 81a) what would be the proper dose for y?
    Some do but it isnt really recommended because of the combinations interaction on heart rate and blood pressue.
    PESCIENCE.COM

    "The only good is knowledge and the only evil is ignorance." - Socrates
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