How much vitamin C is too much?

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    How much vitamin C is too much?


    What doses are people taking and if not, then why? Is extra vitamin C from supplements necessary for body builders?

    United States vitamin C recommendations

    Recommended Dietary Allowance (adult male)90 mg per day
    Recommended Dietary Allowance (adult female)75 mg per day
    Tolerable Upper Intake Level (adult male)2,000 mg per day
    Tolerable Upper Intake Level (adult female)2,000 mg per day

    A lot of vitamins nowadays have 1000mg in them but is that necessary to add into someone's diet? There are a lot of health benefits as well

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    In for answers. I take it in the morning if I drank the night before, does wonders for a hangover for me.
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    Quote Originally Posted by Bryancap77 View Post
    In for answers. I take it in the morning if I drank the night before, does wonders for a hangover for me.
    Yeah I just added 1000mg a day too

    Haven't tried that though!
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    Any effect vitamin C has on hangovers is likely placebo honestly. I don't see much merit in supplementing vitamin C unless using nitrates or warding off illness (Ester-C)
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    Quote Originally Posted by mr.cooper69 View Post
    Any effect vitamin C has on hangovers is likely placebo honestly. I don't see much merit in supplementing vitamin C unless using nitrates or warding off illness (Ester-C)
    Good point. I know a few people that dose it high as 2000mg ED

    A bit of a overkill
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    Plasma saturation occurs at 500mg so any more than this at any one time will be excreted. I'm not too sure why you would go much above this to be honest.
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    Quote Originally Posted by Jiigzz View Post
    Plasma saturation occurs at 500mg so any more than this at any one time will be excreted. I'm not too sure why you would go much above this to be honest.
    That's wrong the percentage utilized decreases as you increase the dose but there is no 500 mg limit.
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    Quote Originally Posted by Quadzilla99 View Post
    That's wrong the percentage utilized decreases as you increase the dose but there is no 500 mg limit.
    Interesting
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    Quote Originally Posted by BBB View Post
    Interesting read. Kind of supports the reason I use it. Maybe that's why I'm rarely ever sick?
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    Quote Originally Posted by Bryancap77 View Post
    Interesting read. Kind of supports the reason I use it. Maybe that's why I'm rarely ever sick?
    Don't forget the D3 and Fish Oil.
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    Quote Originally Posted by BBB View Post

    Don't forget the D3 and Fish Oil.
    Fish oil twice a day, about 1800mg's omega 3's, does wonders for my joints!
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    I don't really see the need to supplement with Vit. C in the first place.

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    I take 500mgs EsterC 3-4 times throughout the day usually with meals or with my pre-workout drink. Spacing my doses out helps works better for me,no issues with diarrea that way I think it helps with my immune system,cortisol control and with all the nitrates I consume.
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    Quote Originally Posted by Quadzilla99 View Post
    That's wrong the percentage utilized decreases as you increase the dose but there is no 500 mg limit.
    I stand corrected. However supplementing with over 1000mg will increase half-life to 30 minutes compared to normal dietary intakes which may last 8-40 days.
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    I use Ascorbic Acid crystals and bump it up to 8g a day when I feel a cold or virus coming on and 9 out of 10 times it stops it dead in its tracks. Then I slowly scale it down to 1 to 2g daily maintenance.

    Host of benefits. If I recall its also a potent NOS inhibitor.
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    Very interesting info!

    I think maybe vitamin C is starting to show more benefits
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    Quote Originally Posted by Clemenza View Post
    I use Ascorbic Acid crystals and bump it up to 8g a day when I feel a cold or virus coming on and 9 out of 10 times it stops it dead in its tracks. Then I slowly scale it down to 1 to 2g daily maintenance.Host of benefits. If I recall its also a potent NOS inhibitor.
    You're not concerned with Vit. C becoming pro-oxidant at that point?

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    I take about 3000mg spread evenly throughout the day. I've read that somewhere around 8000mg and you start getting the squirts.

    I haven't been sick in years.
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    Fwiw NO HYPE is/was a fan of mega dosing vitamin C for glutathione enhancing reasons
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    Quote Originally Posted by Quadzilla99 View Post
    Fwiw NO HYPE is/was a fan of mega dosing vitamin C for glutathione enhancing reasons
    I've heard it's excellent for eye health
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    Quote Originally Posted by aaronuconn View Post
    You're not concerned with Vit. C becoming pro-oxidant at that point?
    I am. But I guess you can make the argument that too much of many anti oxidants can promote pro oxidant activities. Like ALCAR. But how much is too much? At what dose does an anti oxidant become a dangerous pro oxidant?

    Theres a study that showed the potential for ascorbic acid to exhibit pro oxidant / cytotoxic activity in tumors but not in normal cells.

    With all the environmental toxicities out there I'd rather take my chances with extra anti oxidants. Unless I find overwhelming exidence of a specific dose of an anti oxidant to be dangerous.

    You do bring up a good point though.
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    Quote Originally Posted by Clemenza View Post
    I am. But I guess you can make the argument that too much of many anti oxidants can promote pro oxidant activities. Like ALCAR. But how much is too much? At what dose does an anti oxidant become a dangerous pro oxidant?

    Theres a study that showed the potential for ascorbic acid to exhibit pro oxidant / cytotoxic activity in tumors but not in normal cells.

    With all the environmental toxicities out there I'd rather take my chances with extra anti oxidants. Unless I find overwhelming exidence of a specific dose of an anti oxidant to be dangerous.

    You do bring up a good point though.
    You should dose anything more than 500 mg well away from workouts though. Like maybe take your biggest doses upon waking or before going to bed
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    Quote Originally Posted by Quadzilla99 View Post
    You should dose anything more than 500 mg well away from workouts though. Like maybe take your biggest doses upon waking or before going to bed
    Agreed. Anything with COX-2 inhibiting properties (anti-inflammatories typically fall in this category) should be dosed ~4 hours peri-workout.

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    Quote Originally Posted by Quadzilla99 View Post

    You should dose anything more than 500 mg well away from workouts though. Like maybe take your biggest doses upon waking or before going to bed
    Of vitamin c? How come? I usually try and do 500mg pre workout. 1g breakfast. 500mg before bed.
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    Quote Originally Posted by Clemenza View Post
    Of vitamin c? How come? I usually try and do 500mg pre workout. 1g breakfast. 500mg before bed.
    http://forum.bodybuilding.com/showth...4356443&page=1
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    Quote Originally Posted by Clemenza View Post
    I use Ascorbic Acid crystals and bump it up to 8g a day when I feel a cold or virus coming on and 9 out of 10 times it stops it dead in its tracks. Then I slowly scale it down to 1 to 2g daily maintenance.

    Host of benefits. If I recall its also a potent NOS inhibitor.
    No real evidence to suggest mega-dosing actually works beyond that of placebo, although it isn't well researched so who knows; but at those dosages, the half life would be incredible low.

    Edit: It seems as though the ascorbyl radical itself (technically a prooxidant) is not overly potent due to the position of the free radical group

    I think many people get carried away with Vit C supplementation and assume that because it is so good at lower dosages; it must be better at higher dosages.

    Vit C also doesn't preserve eNO2 per se, that is a function of any antioxidant; not just that of Vit C.
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    Quote Originally Posted by Jiigzz View Post

    No real evidence to suggest mega-dosing actually works beyond that of placebo, although it isn't well researched so who knows; but at those dosages, the half life would be incredible low.

    Edit: It seems as though the ascorbyl radical itself (technically a prooxidant) is not overly potent due to the position of the free radical group

    I think many people get carried away with Vit C supplementation and assume that because it is so good at lower dosages; it must be better at higher dosages.

    Vit C also doesn't preserve eNO2 per se, that is a function of any antioxidant; not just that of Vit C.
    Low half life which is why when mega dosing its recommended to divide over 4 to 8 doses a day. Even during maintenance I don't take over 500mg at a time.

    There is a ton of evidence showing vitamin c to be anti bacterial, anti viral, promoting immune function, even necessary in the development of t cells.

    I don't know how anyone can say immune benefits from vitamin c are placebo.
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