I believe there is s mouse study showing mega dosing vitamin c to be anti tumor. Another study showing mega dosing to be relatively safe. I haven't seen any studies showing mega dosing c to be of zero benefit so maybe its still up in the air.
I'm a big follower of Linus Pauling who I believe was way ahead of his time.
Anecdotally I can say when I feel a cold coming on while maintaining at 1g a day and I bump up to 4 to 8g, that cold is gone almost immediately every time.
Ann Intern Med. 2004 Apr 6;140(7):533-7.
Vitamin C pharmacokinetics: implications for oral and intravenous use.
Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M.
Source
National Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer Institut, and the Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1372, USA.
Abstract
BACKGROUND:
Vitamin C at high concentrations is toxic to cancer cells in vitro. Early clinical studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-blind, placebo-controlled trials showed none. However, these studies used different routes of administration.
OBJECTIVE:
To determine whether plasma vitamin C concentrations vary substantially with the route of administration.
DESIGN:
Dose concentration studies and pharmacokinetic modeling.
SETTING:
Academic medical center.
PARTICIPANTS:
17 healthy hospitalized volunteers.
MEASUREMENTS:
Vitamin C plasma and urine concentrations were measured after administration of oral and intravenous doses at a dose range of 0.015 to 1.25 g, and plasma concentrations were calculated for a dose range of 1 to 100 g.
RESULTS:
Peak plasma vitamin C concentrations were higher after administration of intravenous doses than after administration of oral doses (P < 0.001), and the difference increased according to dose. Vitamin C at a dose of 1.25 g administered orally produced mean (+/-sd) peak plasma concentrations of 134.8 +/- 20.6 micromol/L compared with 885 +/- 201.2 micromol/L for intravenous administration. For the maximum tolerated oral dose of 3 g every 4 hours, pharmacokinetic modeling predicted peak plasma vitamin C concentrations of 220 micromol/L and 13 400 micromol/L for a 50-g intravenous dose. Peak predicted urine concentrations of vitamin C from intravenous administration were 140-fold higher than those from maximum oral doses.
LIMITATIONS:
Patient data are not available to confirm pharmacokinetic modeling at high doses and in patients with cancer.
CONCLUSIONS:
Oral vitamin C produces plasma concentrations that are tightly controlled.
Only intravenous administration of vitamin C produces high plasma and urine concentrations that might have antitumor activity. Because efficacy of vitamin C treatment cannot be judged from clinical trials that use only oral dosing, the role of vitamin C in cancer treatment should be reevaluated.
This study?
I guess it wouldn't matter much anyway, high dosages yield low half-lives and those doses being spaced out (i.e. 500mg-1000mg at any one time) doesn't appear damaging. But I don't know much else about Vit C lol