Coop's Corner #1: Forskolin + B-agonists

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    Post Coop's Corner #1: Forskolin + B-agonists


    This will be the first of a series of interesting studies and analysis. It's posted here rather than the science section because I think everyone can benefit from knowing this stuff.

    Today's topic is how forskolin synergizes with B-agonists in actual humans for the purpose of fat loss.

    Here is the paper I'm referencing: Forskolin Potentiates Isoprenaline-Induced Glycerol Output and Local Blood Flow in Human Adipose Tissue in vivo - Enoksson - 2009 - Pharmacology & Toxicology - Wiley Online Library.

    Forskolin, by acting downstream of the b-adrenergic receptor, increases adenyl cyclase activity and thus elevates cAMP. This amplifies the intracellular signal saying "burn fat," such that the body interprets normal B-receptor stimulation as something greater. The combination will maximize fat loss in a given period of time.

    B-Agonists you can use: ECA stack, Alphamine, Alpha-T2
    Forskolin products you can use: Forskolin-95, Primaforce Forskolin, PNI Paragon

    Happy fat loss everyone!
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    The above is my own opinion and does not reflect the opinion of PES

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    would albuterol or clen work well with forskolin-95 too?
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    Quote Originally Posted by mr.cooper69 View Post
    This will be the first of a series of interesting studies and analysis. It's posted here rather than the science section because I think everyone can benefit from knowing this stuff.

    Today's topic is how forskolin synergizes with B-agonists in actual humans for the purpose of fat loss.

    Here is the paper I'm referencing: Forskolin Potentiates Isoprenaline-Induced Glycerol Output and Local Blood Flow in Human Adipose Tissue in vivo - Enoksson - 2009 - Pharmacology & Toxicology - Wiley Online Library.

    Forskolin, by acting downstream of the b-adrenergic receptor, increases adenyl cyclase activity and thus elevates cAMP. This amplifies the intracellular signal saying "burn fat," such that the body interprets normal B-receptor stimulation as something greater. The combination will maximize fat loss in a given period of time.

    B-Agonists you can use: ECA stack, Alphamine, Alpha-T2
    Forskolin products you can use: Forskolin-95, Primaforce Forskolin, PNI Paragon

    Happy fat loss everyone!
    Waiting to stack it with versa1 n compound 20 at double dose. So we will see.
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    Quote Originally Posted by OnionKnight View Post
    would albuterol or clen work well with forskolin-95 too?
    Although I can't formally recommend them, yes.

    Quote Originally Posted by EBF Inc View Post
    Waiting to stack it with versa1 n compound 20 at double dose. So we will see.
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    Good info.. will be following! You should re-write the studies in cliff form to make it easier for us lazy guys

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    Quote Originally Posted by criticalbench View Post
    Good info.. will be following! You should re-write the studies in cliff form to make it easier for us lazy guys

    Mike
    Here's the basic rundown:

    A activates B. B activates C. C activates D. D activates fat burning.

    A B-agonist increases levels of A. More A means more B. More B means more C.

    Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
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    Great stuff. Thanks for the post and keep 'me coming!
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    What is an effective dose?
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    Quote Originally Posted by mr.cooper69 View Post
    Here's the basic rundown:

    A activates B. B activates C. C activates D. D activates fat burning.

    A B-agonist increases levels of A. More A means more B. More B means more C.

    Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
    LOL

    I think following that confused me more than the original post haha
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    I love it.
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    Quote Originally Posted by mr.cooper69 View Post

    Here's the basic rundown:

    A activates B. B activates C. C activates D. D activates fat burning.

    A B-agonist increases levels of A. More A means more B. More B means more C.

    Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
    Now to get this effect whats the min and max dosage?
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    I am also curious as to coopers forskolin dosing protocol for this
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    Coop had answered a q I had about forsk dose timing related to fast loss...as I dose most of my forsk preWO, then some postWO...he said it didn't...wondering if forsk activates all these things and is further potentiated by the listed stims, if dosing most preWO wouldn't be the most beneficial for fat loss...hmmmm...
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    Love this thread. I usually dose at least 25mgs of Forskolin-95 with each of my Alphamine doses.
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    i think this is the first thread where i understand coops post without googling half the words
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    Guess I'll do my dosing of F95: 1 cap preworkout with my AT2 + preworkout/Alphamine, 1 cap post workout, 1 cap on the second dose of AT2+Shift, 1 cap before bed with Shift.
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    Does Forskolin offer any benefits in relation to lean body mass increase or is it more towards fat loss?
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    Good info especially with the sale on for95 right now
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    Im thinkin dexaprine/tt-33/forsk stack and go full potato
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    500mg of 10% is the studied dose so 50mg of 95% should yeild equivalent results
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    Quote Originally Posted by JudoJosh View Post
    500mg of 10% is the studied dose so 50mg of 95% should yeild equivalent results
    I was guessing 50mg min and 75mg should be the sweet spot.
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    Awesome thread. Forskolin is one of my favorite ingredients.
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    Forsk and Alphamine one two combo. BAM! Simple and effective
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    Quote Originally Posted by mr.cooper69 View Post

    Here's the basic rundown:

    A activates B. B activates C. C activates D. D activates fat burning.

    A B-agonist increases levels of A. More A means more B. More B means more C.

    Forskolin further increases levels of C. So you have way, way more C, which activates D. D activates way, way more fat burning.
    I love it when my "d" gets active.
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    Quote Originally Posted by OnionKnight View Post
    i think this is the first thread where i understand coops post without googling half the words
    Lol agreed ^
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    I dose 1-2 forskoin-95 caps with each scoop of alphamine. It totals to 50-150mg daily
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    The above is my own opinion and does not reflect the opinion of PES
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    Quote Originally Posted by mr.cooper69 View Post
    I dose 1-2 forskoin-95 caps with each scoop of alphamine. It totals to 50-150mg daily
    So you're usually dosing the F95 on an empty stomach? I've been trying to dose mine 15-20 min before breakfast & dinner. But I didn't know if it makes a difference.
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    Great post OP
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    Quote Originally Posted by mr.cooper69 View Post
    I dose 1-2 forskoin-95 caps with each scoop of alphamine. It totals to 50-150mg daily
    50mg Being the least and 150mg being the most. Now does the dose depend on body weight? If it doesn't than whats the difference in terms of effects?
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    I've been stacking Pure Forskolin with Compound 20 with a great results in the past. with added Alphamine it would be a killer stack
    i find that 75mg of Forskolin (pure) is the perfect spot. really enjoy the benifets of forskolin!
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    Quote Originally Posted by ddfox View Post
    So you're usually dosing the F95 on an empty stomach? I've been trying to dose mine 15-20 min before breakfast & dinner. But I didn't know if it makes a difference.
    With or without meals won't matter with the 95%. Forskolin has pretty decent retention time too

    Quote Originally Posted by halfhuman View Post
    50mg Being the least and 150mg being the most. Now does the dose depend on body weight? If it doesn't than whats the difference in terms of effects?
    The studies don't titrate according to bodyweight, but I'd say yes, the effects are weight-dependent. Lower doses create subtler body composition changes, while higher doses have your thyroid output, testosterone production, lipolysis, anabolic signaling, and vasodilation maxed out.
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    Some sweet info in this thread. I'll definitely be picking up some forskolin to go with my next alphamine run.
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    Quote Originally Posted by mr.cooper69 View Post


    The studies don't titrate according to bodyweight, but I'd say yes, the effects are weight-dependent. Lower doses create subtler body composition changes, while higher doses have your thyroid output, testosterone production, lipolysis, anabolic signaling, and vasodilation maxed out.
    So would the effects of forskolin be "extra" noticeable or good in someone with an under active thyroid?
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    Quote Originally Posted by SoupNaziNazi View Post
    So would the effects of forskolin be "extra" noticeable or good in someone with an under active thyroid?
    The most common cause of hypothyroidism, Hashimoto's, would be unaffected since it results in autoimmune destruction of the thyroid.
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    Is cycling necessary... how long can you run it
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    Quote Originally Posted by mr.cooper69 View Post

    The most common cause of hypothyroidism, Hashimoto's, would be unaffected since it results in autoimmune destruction of the thyroid.
    Google here I come!
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    Quote Originally Posted by doggy_dog View Post
    Does Forskolin offer any benefits in relation to lean body mass increase or is it more towards fat loss?
    I read a study a while back where it suggest that forskolin did offer benefits in relations to increased lean body tissue, but I believe the study was done on untrained individuals (female and males I believe). I'd have to try and find the study.
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    Quote Originally Posted by mpaquett View Post

    I read a study a while back where it suggest that forskolin did offer benefits in relations to increased lean body tissue, but I believe the study was done on untrained individuals (female and males I believe). I'd have to try and find the study.
    It activated glp-1 as well
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    How should forskolin be cycled? I've been using 100mg analyzed Supplements Forskolin 95 a day with OG Anabeta for July and August. Can I continue to run it or should I give it s month break and then get back on it?
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    Could have sworn I saw a few people recommend 12 weeks.
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