New DAA Study

[De__eB]

[h=1]d-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men[/h]
Odd given the study showing it did have an effect, and the plethora of people who have done bloodwork on themselves.

But, I generally trust a study that come out of the Baylor HPL.

 

[T-Bone]

I disagree.

 

[JudoJosh]

Interesting. Perhaps it is the age difference? The Topo et al study used men 27-37 while this when used men 18-23. It is possible that the T levels for the men in this study were already in the upper range so DAA didnt make as much of an impact as it did for the other study.

 

[JudoJosh]

I disagree.

What is it you disagree with? Please elaborate what exactly in this study it is that you have a problem with

 

[T-Bone]

Interesting. Perhaps it is the age difference? The Topo et al study used men 27-37 while this when used men 18-23. It is possible that the T levels for the men in this study were already in the upper range so DAA didnt make as much of an impact as it did for the other study.

That makes sense. DAA is pretty dramatic as far as results go when I take it. I turned 41 last month.

 

[T-Bone]

What is it you disagree with? Please elaborate what exactly in this study it is that you have a problem with

I disagree with what is printed in red in the first post.

 

[mr.cooper69]

Someone get me the full text please. It's plausible that the fact that DAA didn't even significantly increase plasma levels is indicative of the fact that bulk DAA has a very poor bioavailability (vs the sodium DAA in the 42% study). But idk if they used sodium DAA [email protected] would like the FT though

 

[JudoJosh]

Someone get me the full text please. It's plausible that the fact that DAA didn't even significantly increase plasma levels is indicative of the fact that bulk DAA has a very poor bioavailability (vs the sodium DAA in the 42% study). But idk if they used sodium DAA [email protected] would like the FT though

I sent it mr.Statistics69

 

[mr.cooper69]

Got it, thanks. The study looks very well-conducted. One thing I will say is that the effect of DAA on LH, while not statistically significant, appears to be considerable, especially since GnRH decreased in both groups. So another theory for these results is that 1 month of supplementation allows adequate homeostatic compensation to occur in response to increased LH release by DAA. But again, just a theory

 

[JudoJosh]

bulk DAA has a very poor bioavailability (vs the sodium DAA in the 42% study). But idk if they used sodium DAA here...

Considering that solubility of aminos is a function of pH, there really shouldn't be a difference in DAA vs sodium d-aspartate.

I messaged you some additional thoughts on this

 

[JD261985]

Someone get me the full text please. It's plausible that the fact that DAA didn't even significantly increase plasma levels is indicative of the fact that bulk DAA has a very poor bioavailability (vs the sodium DAA in the 42% study). But idk if they used sodium DAA [email protected] would like the FT though

Guess that's why TCF 1 works so good huh? The delivery system

 

[mr.cooper69]

Considering that solubility of aminos is a function of pH, there really shouldn't be a difference in DAA vs sodium d-aspartate.

I messaged you some additional thoughts on this

Except that ionic bonding to sodium or chelation with Mg/Ca results in a salt or chelate, not an amino acid

 

[mr.cooper69]

Guess that's why TCF 1 works so good huh? The delivery system

More the form (sodium) than delivery, but yes, homogenization does help

 

[JudoJosh]

Once DAA is dissolved in water the pH of minimum solubility is about pH 3.0 and once it enters the stomach it is neutralized to about a pH of 7-8 at which point DAA should become pretty damn soluble.

Yes the sodium bonding changes the solubility but this is its solubility in water, not the gut. Once DAA enters the gut the lack of solubility in water at a neutral pH really becomes irrelevant when we are discussing bioavailability and absorption, does it not? I honestly dont see why this should matter

 

[LiveToLift]

Interesting discussion! I'll tag along.

 

[mr.cooper69]

Once DAA is dissolved in water the pH of minimum solubility is about pH 3.0 and once it enters the stomach it is neutralized to about a pH of 7-8 at which point DAA should become pretty damn soluble.

Yes the sodium bonding changes the solubility but this is its solubility in water, not the gut. Once DAA enters the gut the lack of solubility in water at a neutral pH really becomes irrelevant when we are discussing bioavailability and absorption, does it not? I honestly dont see why this should matter

I don't follow this post. The pH of a DAA solution is neutralized in the stomach?

 

[JD261985]

More the form (sodium) than delivery, but yes, homogenization does help

Is DAA magnesium chelate stronger than sodium DAA?

 

[mr.cooper69]

Is DAA magnesium chelate stronger than sodium DAA?

I'm not sure. It has less DAA per gram, but I'd expect the total uptake to be a tad higher

 

[De__eB]

I disagree with what is printed in red in the first post.

That was just the title of the paper not my thoughts just to be certain

 

[Aleksandar37]

This is horribly written!

"Because there are data supporting the role of D-ASP supplementation in increasing endogenous testosterone levels, this amino acid product may prove beneficial as a means in which to increase muscle performance associated with heavy resistance training. However, because there appears to be a paucity of human studies dealing with D-ASP supplementation, and apparently none when D-ASP is ingested in conjunction with resistance training, we hypothesized that D-ASP would not increase endogenous testosterone levels or improve muscular performance associated with resistance training."

 

[bdcc]

Who wants to be a jolly good fellow and send me the FT as well please?

 

[mcc23]

So have we arrived at a consensus about DAA then?

 

[rob112]

I'm kind of surprised at the little increase of hormones compared to the 42% study, but not surprised at all in the other results. I've enjoyed DAA outside of GI issues, but testing strength and muscle mass...I mean isn't that more of a exogenous hormone thing and not a natural test booster thing?

I can only see the abstract so I can't see all the details.

 

[MonteRXS]

I'd like to read the FT as well. Any body have a link to it the FT article?

 

[Grambo]

That makes sense. DAA is pretty dramatic as far as results go when I take it. I turned 41 last month.

I believe this is the main aspect. The lower you are the more affect it may have.
I definitely notice when I am using DAA personally. I run on the lower end of normal in my levels, though I feel great and have no symptoms.

 

[Grambo]

So have we arrived at a consensus about DAA then?

A single study definitely doesn't make a consensus. It's an interesting study though.

 

[Grambo]

On a similar note I know of a similar study going on right now that will be peer reviewed and published, hopefully by the end of the year......

 

[mr.cooper69]

On a similar note I know of a similar study going on right now that will be peer reviewed and published, hopefully by the end of the year......

On D-pol, no?

 

[Grambo]

On D-pol, no?

Yep you got it. Should be pretty interesting.
They were excited about it this weekend while I was helping out with the Dallas Europa.

 

[jimbuick]

Yep you got it. Should be pretty interesting.
They were excited about it this weekend while I was helping out with the Dallas Europa.

Speaking of the Europa; did you save me a shirt like I asked?!?

 

[Grambo]

Speaking of the Europa; did you save me a shirt like I asked?!?

I didn't even get a shirt! They threw them all into the crowd/shirt cannon before I could get my hands on one

I do have a bunch of extras of the new shirts. What size?

 

[jimbuick]

I didn't even get a shirt! They threw them all into the crowd/shirt cannon before I could get my hands on one

I do have a bunch of extras of the new shirts. What size?

That's ridiculous.


XL.

 

[jimbuick]

Ive been looking at those black EL/ST shirts for a while, and the new grey looks awesome.

Hopefully, I can afford to get some soon to go with my red one.

 

[Grambo]

Ive been looking at those black EL/ST shirts for a while, and the new grey looks awesome.

Hopefully, I can afford to get some soon to go with my red one.

I have an XL in each ill hook it up. PM me

 

[mcc23]

I believe this is the main aspect. The lower you are the more affect it may have.
I definitely notice when I am using DAA personally. I run on the lower end of normal in my levels, though I feel great and have no symptoms.

I won some DAA from Allmax the other day but after reading the study (and Coop's opinion regarding it) I think I won a tub of Placebo powder :34:

 

[sdunlimited]

Also interested in the FT. Anybody have additional details they can provide?

Tx

 

[bdcc]

I'd like to read the FT as well. Any body have a link to it the FT article?

Also interested in the FT. Anybody have additional details they can provide?

Tx

Josh sent it to me so I have it. Send me your email addresses.

 

[MonteRXS]

Josh sent it to me so I have it. Send me your email addresses.

Thanks Ben!