Yohimbine HCL with Leucine?

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    Yohimbine HCL with Leucine?


    Okay, so I know that Yohimbine HCL has to be used fasted because the increase in insulin will negate the effect of Yohimbine. Now, Leucine is also the only strict ketogenic amino acid.

    My three questions are

    Will taking Leucine fasted increase insulin and negate Yohimbine HCL for fat loss?

    Is it even necessary to take Leucine in this scenario for muscle preservation? (does it help?)

    If so, how much Leucine would be sufficient?

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    Regardless of leucine's metabolic fate, it will transiently stimulate insulin release. I mean super-transiently since it's free form. The net effect on lipolysis will be virtually nothing. So feel free to take leucine with yohimbine
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    I dont see why you would add leucine in. Just take yohimbine on its own
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    Probably cause he is fasted and wants to preserve muscle....
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    Quote Originally Posted by mr.cooper69 View Post
    Regardless of leucine's metabolic fate, it will transiently stimulate insulin release. I mean super-transiently since it's free form. The net effect on lipolysis will be virtually nothing. So feel free to take leucine with yohimbine
    I remember reading a while back leucine will only stimulate insulin release in presence of carbohydrates. It's was an exerpt from a different study looking at insulinogenic ingredients

    Leucine with yohimbine is perfectly good to stack together. May even feed off each other for post workout insulin response and mtor signaling
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    Quote Originally Posted by JudoJosh View Post
    I dont see why you would add leucine in. Just take yohimbine on its own
    Well, if the goal is fat loss, wouldn't you see benefit from positive nitrogen balance AND controlled catabolic state utilizing fat as energy? I thought Leucine would achieve the first part, while Yohimbine would achieve the second part, given that insulin isn't effected by ingesting Leucine. There are also studies that support Leucine as having positive effects for this:

    Nutr Metab (Lond). 2008; 5: 20.
    Published online 2008 July 17. doi: 10.1186/1743-7075-5-20
    PMCID: PMC2488337
    Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies

    J Clin Invest. 1975 November; 56(5): 1250–1261.
    doi: 10.1172/JCI108201
    PMCID: PMC301988
    Leucine. A possible regulator of protein turnover in muscle.

    Sports Med. 1999 Jun;27(6):347-58.
    Leucine supplementation and intensive training.
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    Yohimbine blocks alpha-adrenergic fat-cell receptors thus promoting the release of norepinephrine (catecholamine hormone) which should decrease the rate of muscle catabolism. Granted yohimbine doesn't promote epinephrine release directly like ephedrine does so the muscle sparring effects wont be exactly the same (ephedrine would be better) yohimbine should still help somewhat. Besides your not really at risk for a large amount of muscle catabolisim anyway. Just take the yohimbine and call it a day
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