As for being a non responder I'll say if I see overwhelming evidence from multiple real world applications then I won't be afraid to offer that supplement as a suggestion even though I didn't experience any of the benefits.
That a good enough answer for you?
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" If you're looking for a work house.......I'm no Clydesdale."
I know that this is a problem and Big Pharma has a lot to do with the problem.
The video describes it as well, studies with negative results never get published but when on their 7th trial, the results "change" they publish the "fluke" results apply for FDA approval. Im sure it doesn't always happen but it has been shown to happen a lot. I can't post links but google search publication bias Pharmaceutical Industry