ndnguy85
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I have been reading more into neurotransmitters and these caught my attention. What's everyone's opinion on it?
Seems cheap/too good to be true..?
Seems cheap/too good to be true..?
5-HTP and Tyrosine put me in a great mood when I take them. Can't speak on GABA, however.I have been reading more into neurotransmitters and these caught my attention. What's everyone's opinion on it?
Seems cheap/too good to be true..?
What are you trying to achieve? What are your goals? Help with sleep? Reducing anxiety? Growth hormone secretion? Deeper sleep? Dopamine or well being? Happiness/help depression??I have been reading more into neurotransmitters and these caught my attention. What's everyone's opinion on it?
Seems cheap/too good to be true..?
Anything medication/supplement that affects neurotransmitters in a positive/negative way taken for a period of time, can cause minor withdrawal symptoms if discontinued abruptly. Easy to avoid though.Is Gaba/5-htp addictive? Withdrawal symptoms?
All good input and info. I start slow and take only when needed. Gaba and 5 htp together on the same night and I'm a zombie for three hours at work. I'll drink a whole pot of coffee before I feel normal. Some of these work just like a 'medication' meaning they have side effects too.I'd be careful with these types of supplements...Gaba I don't like much because of the "Gaba rush". Google "Gaba rush". It's extremely unpleasant. 5 Htp can increase serotonin levels. It can cause interactions with medications or some other supplements. It's just something I wouldn't mess with or take long term. Tyrosine I'm not too sure about. I believe it can increase dopamine levels somewhat. Gaba I believe to be relatively safe but I just don't react well to it at all.
Ever try PEA?...I think it works pretty well at reducing stress. Try SNS Pea-500 at Nutraplanet. It's a wicked good price and should last you a while. Pretty sure that that is a sale price though. You could get rid of the the Gaba and 5HTP and replace it with this one product. I don't think it will put you to sleep either. I've tried it a while back and it works well to reduce stress. To be honest it wasn't SNS brand but it was before I even knew SNS existed. It can act as a stimulant also, but won't have you freaking out. Of course PEA can also interact with prescriptions. Just be careful with any of these types of supplements and never go over the recommended dosage. Reason I say try PEA is because it can give you energy and focus and also help relieve stress. Plus I've tried it before and it worked pretty good for me. It's not something you want to take before bed. Try taking it before work with a cup of coffee. I wouldn't stack it with 5HTP, L-Dopa, or the other similar type supplements mentioned in this thread.All good input and info. I start slow and take only when needed. Gaba and 5 htp together on the same night and I'm a zombie for three hours at work. I'll drink a whole pot of coffee before I feel normal. Some of these work just like a 'medication' meaning they have side effects too.
I'm inclined to agree if you are ONLY taking these for appetite suppression.Ever try PEA?...I think it works pretty well at reducing stress. Try SNS Pea-500 at Nutraplanet. It's a wicked good price and should last you a while. Pretty sure that that is a sale price though. You could get rid of the the Gaba and 5HTP and replace it with this one product. I don't think it will put you to sleep either. I've tried it a while back and it works well to reduce stress. To be honest it wasn't SNS brand but it was before I even knew SNS existed. It can act as a stimulant also, but won't have you freaking out.
I'm inclined to agree if you are ONLY taking these for appetite suppression.
im a big fan of n-acetyl-tyrosine (said to be 20x better absorbed) and tyrosine ethyl ester; expensive getting them in a store, but oh so cheap in bulk. I find a noticeable improvement in energy at 1/4 teaspoon 3 times a day. a precursor to dopamine, adrenaline and noradrenaline whats not to love? it also benefits the thyroid. gaba is good for a lot of things and there is an uber-potent form of that bound to niacin, but as with 5-htp, I have a hard time welcoming the drowsiness being on the chill side already myself; ive seen labels for 5-htp will cautioning users not to drive after dosing, as the sleep can really come on. definitely powerful thoughI have been reading more into neurotransmitters and these caught my attention. What's everyone's opinion on it?
Seems cheap/too good to be true..?
I'm about to Google. Wow thyroid benefits & energy?!?! Any info in how it helps thyroid? Hypo or hyper? Which form is better the N.A.T? Or T.E.E.?im a big fan of n-acetyl-tyrosine (said to be 20x better absorbed) and tyrosine ethyl ester; expensive getting them in a store, but oh so cheap in bulk. I find a noticeable improvement in energy at 1/4 teaspoon 3 times a day. a precursor to dopamine, adrenaline and noradrenaline whats not to love? it also benefits the thyroid.
N-Acetyl-Tyrosine actually has worse overall CNS penetration and body retention. Adding an ethyl ester is worthless too.im a big fan of n-acetyl-tyrosine (said to be 20x better absorbed) and tyrosine ethyl ester; expensive getting them in a store, but oh so cheap in bulk. I find a noticeable improvement in energy at 1/4 teaspoon 3 times a day. a precursor to dopamine, adrenaline and noradrenaline whats not to love? it also benefits the thyroid. gaba is good for a lot of things and there is an uber-potent form of that bound to niacin, but as with 5-htp, I have a hard time welcoming the drowsiness being on the chill side already myself; ive seen labels for 5-htp will cautioning users not to drive after dosing, as the sleep can really come on. definitely powerful though
L-Tyrosine is the best form. It doesn't benefit the thyroid, it's just a thyroid hormone precursor (but if you're not deficient, taking more won't induce T3 release...remember, thyroid hormone is stored as thyroglobulin)I'm about to Google. Wow thyroid benefits & energy?!?! Any info in how it helps thyroid? Hypo or hyper? Which form is better the N.A.T? Or T.E.E.?
Here's all you should take away from that:TYROSINE OVERVIEW INFORMATION
Tyrosine is one of the amino acids, which are the building blocks of protein. The body makes tyrosine from another amino acid called phenylalanine. Tyrosine can also be found in dairy products, meats, fish, eggs, nuts, beans, oats, and wheat.
People take tyrosine for depression, attention deficit disorder (ADD), attention deficit-hyperactivity disorder (ADHD), the inability to stay awake (narcolepsy), and improving alertness following sleep deprivation. It is also used for stress, premenstrual syndrome (PMS), Parkinson's disease, Alzheimer's disease, chronic fatigue syndrome (CFS), alcohol and cocaine withdrawal, heart disease and stroke, ED (erectile dysfunction), loss of interest in sex, schizophrenia, and as a suntan agent and appetite suppressant.
I take it from time to time. Just don't combine it with yohimbine.Cooper, do you take L-Tyrosine?
I guess I can start with that one and see how I react before messing around with 5-HTP and Gaba.
Where does L-Glutamine play into all this in terms of appetite suppression etc?
Nor have IThere is nothing wrong with taking 5htp ya ninnies. One person says one thing and then the thread spirals lol...
For whoever 5htp turns into a "zombie" what dose are you taking? I've taken 5htp frequently in upwards of 200mg to help replenish serotonin after times of little sleep or strenuous workouts and fires. I've never even become overly drowsy lol
ive taken every form there is. never saw the energy benefits of straight up l-tyrosine. i have people tell me there's no difference between isolated B vitmains and coenzymated ones, and that 50g of protein a day is all i could ever need but im not going to wait out for all the literature to catch upL-Tyrosine is the best form. It doesn't benefit the thyroid, it's just a thyroid hormone precursor (but if you're not deficient, taking more won't induce T3 release...remember, thyroid hormone is stored as thyroglobulin)
People that don't understand single nucleotide polymorphisms and methylation I would imagine.i have people tell me there's no difference between isolated B vitmains and coenzymated ones,
it's involved in the production of thyroxin. for some, its a missing piece of the equation toward having more thyroxin, so we are steering away from hypo. the dose i took of n-aceetyl is alot over label use, but far less than l-tyrosine recommendations. it was a very clean energy. ive heard people describe it as better than coffee, but i wouldnt go that far. theres just more motivation, less sleeping every nightI'm about to Google. Wow thyroid benefits & energy?!?! Any info in how it helps thyroid? Hypo or hyper? Which form is better the N.A.T? Or T.E.E.?
People that don't understand single nucleotide polymorphisms and methylation I would imagine.
I'm going to give it a whirl, starting with a low dosage.it's involved in the production of thyroxin. for some, its a missing piece of the equation toward having more thyroxin, so we are steering away from hypo. the dose i took of n-aceetyl is alot over label use, but far less than l-tyrosine recommendations. it was a very clean energy. ive heard people describe it as better than coffee, but i wouldnt go that far. theres just more motivation, less sleeping every night
wow. congradulations! there a famous dr, browstein, who really has got alot of interesting information on altering thyroid levels. if i could find his free information books, id remember what minerals he was talking about that are involved with the thyroid as well. copper and selenium came up, but i cant clarify at the moment the effect they had toward what you are achieving. selenium is involved in converting the inactive form of thyroxin to the acitve one, but copper may align with what you are doing; i dont know, i would have to find it and check, but i think i ditched the books he sent.I'm going to give it a whirl, starting with a low dosage.
Since having my DNA tested after labs showing hyperthyroidism in October, I have been able to get off of 4 of the 6 medications I was put on. For me Sam-E was an easy switch off of Zoloft. O side effects and increased relief from ocd/anxiety. Balancing methylation has been a struggle and an ongoing process but well worth it.
well, what i mean to say is that less will do more, since we're talking blood-brain barrier penetration. sns makes a good encapsulated Picamilon (niacin-bound gaba) i thinkBinding gaba to niacin doesn't make it more potent..it just makes it centrally penetrating.
There is nothing wrong with taking 5htp ya ninnies. One person says one thing and then the thread spirals lol...
For whoever 5htp turns into a "zombie" what dose are you taking? I've taken 5htp frequently in upwards of 200mg to help replenish serotonin after times of little sleep or strenuous workouts and fires. I've never even become overly drowsy lol
The biggest thing with it us you want to be careful of down regulation of the other neurotransmitters etc...
do you mean to say hypothyroidism?I'm going to give it a whirl, starting with a low dosage.
Since having my DNA tested after labs showing hyperthyroidism in October, I have been able to get off of 4 of the 6 medications I was put on. For me Sam-E was an easy switch off of Zoloft. O side effects and increased relief from ocd/anxiety. Balancing methylation has been a struggle and an ongoing process but well worth it.
You can experience whatever anecdote you want, but there is human data comparing NAT to L-tyrosine, and it falls considerably short.ive taken every form there is. never saw the energy benefits of straight up l-tyrosine. i have people tell me there's no difference between isolated B vitmains and coenzymated ones, and that 50g of protein a day is all i could ever need but im not going to wait out for all the literature to catch up
Tyrosine is not the missing piece of the equation for anyone on a high protein diet, and it's not even the missing piece of the equation for almost the entirety of the 1st world. We see this problem a lot more in starving nations like Africa.it's involved in the production of thyroxin. for some, its a missing piece of the equation toward having more thyroxin, so we are steering away from hypo. the dose i took of n-aceetyl is alot over label use, but far less than l-tyrosine recommendations. it was a very clean energy. ive heard people describe it as better than coffee, but i wouldnt go that far. theres just more motivation, less sleeping every night
The effects are different because GABA doesn't penetrate the BBB. GABA acts peripherally to induce physical sedation, whereas Picamilon has the ability to change perceptionwell, what i mean to say is that less will do more, since we're talking blood-brain barrier penetration. sns makes a good encapsulated Picamilon (niacin-bound gaba) i think
600mg daily is quite a bithaha. im not saying theres anything wrong with it, and I don't think anyone else is either; im just reporting my experience with it. I took a natrol brand at 200mg, 3x daily for a few days to see what it was all about. natrol is the brand that warns ou on the bottle not to drive until you see how it affects you. on the night of day 5, I went to bed and woke up groggy 14 hours later; It was winter and I only had like 3 hours of dayligt lieft upon rising. stopped taking it, don't plan on ever taking it again. I think a lot of people who spend money on sleeping medication would be way better off with something like 5-htp which also benefits the pineal gland. I also think there are people who might have an unusually low amount of serotonin going for them that would greatly benefit from this.
You can experience whatever anecdote you want, but there is human data comparing NAT to L-tyrosine, and it falls considerably short.
my bad, they said it is 20x more soluable in water than l-tyrosine. , i also think there is something to have the acetyl bonded on for utilization, especially when it comes to something intended for the brain.. people are paying big bucks for acetyl carnitine when they could get carnitine alot cheaper. they pay for it cuz it works better. i wish i could psychologically induce the wakefullness that comes on onsought. i actually tolerance mapped the stuff. too much and the bowels let you know it, i also experienced an intense body heat when taken that amount (think it was 1/4 teason 6x daily) on the day i got the runs from that dose on two occasions. nothing like that happened with l-tyrosine at a bigger dose; i cant accredit that to phychology.
well my point is that people act like there is no additional benefit between taking b vits extracted from tar and taking coenzymated b vitamin supplements, just because the studies arent all over the place.B vitamins aren't a valid comparison unless you are extremely malnourished.
.The science already shows the benefits of a high protein diet. If you want to follow "the science" (aptly named), take note of what is real and what is psychological
im refering to, say jay cutler at 450 grams a day. its not like the literature walks in lockstep with what bodybuilders are sucessfully messing with
well, ive read alot of stuff that says exactly that, and that nobody in america has any deficiencies because we are so well fed. of course, the reality is deficiencies are everywhere as evidenced by the tremendous benefit people get from supplements. you never know whats going on with someone enzymatically; for example, the argument could be made that there's no way anyone needs 1-carboxy on a high protein diet; fact is, tyrosine hydroxylase diminishes with age, so its hardly fair in that case to assume we all got normal levels of l-dopa. i got a spectracell test done; they make a good case for how poor blood tests indicate deficiencies. when you get the results, they send you where you sit compared to everyone whose taken the tests in america. they show vitamins, minerals, and aminos; there ALOT of deficiencies going on in this well fed countryTyrosine is not the missing piece of the equation for anyone on a high protein diet, and it's not even the missing piece of the equation for almost the entirety of the 1st world. We see this problem a lot more in starving nations like Africa.
yeah. i used nutrabio with the plan to bump levels, see what its about, and then get off.600mg daily is quite a bit
The position of the acetyl group matters, and in the case of NAT, it's not analagous to ALCAR. NAT also has like a 100-fold worse kinetic profile and poorer BBB permeability.
you mean worse than acetyl carnitine, sure. you arent saying its worse than l-tyrosine. however poorer NALT BBB absorption to ALCAR may be, that doesnt mean its not better thal l-tyrosine. i also hear really bad things about ethyl-ester aminos as well. in the case of fish oil, i think the ethyl ester doesnt compare to, say, verctomega. HOWEVER, in the case of ornithing ethyl-ester, at a much smaller dose than l-ornithine: the pumps dont lie!!!!!
ok. point taken, but they werent always there. ginko biloba worked thousands of years before a study was done on it to prove it; theres just as much of a chance of somebody being anecdotally off key with somethings's effects as there is with a study being corrupted, being as they are funded by people with motivesThe studies with B-vitamins do exist.
ok, but the point is there's alot we really dont know, yet the substances are available. bodybuilders are always exploring here; those guys are composed of secrets, secrets people would doubt if they heard them, secrets the laboratories dont know aboutJay Cutler eats that much because he has a ton of LBM and runs all sorts of steroids.
i saw this study on improving tyrosine hydroxylase with mice; it didnt occur to me that they might be pre- parkinsons, ibut they did experience improvent in tyrosine hydroxylase expressionLastly, you are completely overstating 1-carboxy (it's L-dopa...) and its utlity with aging. It's not about tyrosine hydroxylase, it's about neuronal death...and it's called parkinson's.
http://www.ncbi.nlm.nih.gov/pubmed/9011759
not sure if tyrosine was on that spectracell test, but there were MANY people who needed non-essential aminos in this country, as evidence on the national test results. my thought was, everybody has a story; some people have cysts and crap in their pancrease, and the enzymes dont get out like they should. pther people just arent making enzymes like they should; hell, we all run out of them, sooner or later; we have a preset amount of them, and when theyre gone, its death by natural causes. i just cant give any credence to any statement predicating what levels of nutrients EVERYBODY has of everything. if the studies on that knew everything, we wouldnt be learning more and more about everything beyond what we knew every year.NO ONE healthy should be deficient in tyrosine because it's not even an essential amino acid. Your body can make it on its own
its got a ring to it, doesnt it? ironically, i think sometimes people miss out on a new discovery and athletic enhancement because a study dissuedes them. i cant find anything of the utmost tangibilty supporting n-acetyl-tyrosine over l-tyrosine and nothing proving theyre the same, but at least 20 companies selling it claim its better absorbed and it crosses the blood brain barrier better. i know they have motive to make claims, but theyre also the only ones around with motive to study that. i take alot of skepticism toward studies about anything pertaining to neurotrasnmitters, given the billions at stake for competing pyschdrugs.Come on. Change the username to TheAnecdote or something
interesting, but thats based on whats seen in the bloodstream; the link didnt get into any measurements lost in urine whatsoever. that's only speculated and they admit it. he fact that there's less nalt in the bloodstream could imply better utilization or absorption into the body. ive heard plenty of arguements that the stuff that remains in the bloodstream is the stuff that isnt getting into the body better; case in point is that natto version of vitamin k. proponents say the stuff is better because its so large that it remains in the bloodstream longer, enabling more opportunity for absorption from the bloodstream. people who say its crap argue that its so big, it just floats around in the bloodstream for 3 days before i it is eventually excreted, being to big to find absorption in the body. i dont know anyone who want a muscle or brain biopsy to adequately test absorption, but blood tests are such a minute and transient representation of what's happening in the body.The problem here is that studies were done on NAT vs Tyrosine. There isn't an absence of data. There is only data proving NAT is inferior.
Read: http://hightowerpharmacology.blogspot.com/2012/12/pharmacology-of-n-acetyl-l-tyrosine.html
Did you read the cited texts? Urinary excretion was the prime measurement, and NAT was excreted much more rapidly (consistent with its greater solubility). I can't do everything here man, gotta do some of your own research too.interesting, but thats based on whats seen in the bloodstream; the link didnt get into any measurements lost in urine whatsoever. that's only speculated and they admit it. he fact that there's less nalt in the bloodstream could imply better utilization or absorption into the body. ive heard plenty of arguements that the stuff that remains in the bloodstream is the stuff that isnt getting into the body better; case in point is that natto version of vitamin k. proponents say the stuff is better because its so large that it remains in the bloodstream longer, enabling more opportunity for absorption from the bloodstream. people who say its crap argue that its so big, it just floats around in the bloodstream for 3 days before i it is eventually excreted, being to big to find absorption in the body. i dont know anyone who want a muscle or brain biopsy to adequately test absorption, but blood tests are such a minute and transient representation of what's happening in the body.
bravo. youre right, i should have looked at those; it was late. i guess i just cant be persuaded because ive tried both forms extensively. the fact that high doses of nalt messed with my bowels supports those studies, as unabsorbed substances can do that, but i have to set my gaze to a study that hasnt been performed yet; for all we know, more is excreted with nalt because peak cellular amounts are achieved more rapidly with much less, which no blood reading can attest to.Did you read the cited texts? Urinary excretion was the prime measurement, and NAT was excreted much more rapidly (consistent with its greater solubility). I can't do everything here man, gotta do some of your own research too.
We can go back and forth on this all day, but why do you support NAT so much? The entirety of the body of science shows its inferior, and this is a sizable amount of literature conducted in humans. There is literally no reason to believe NAT is superior other than a couple claims made by marketing hype artists when NAT was first introduced to the supplement market
If more is excreted, that means less has made it into the cell and gotten converted into L-dopa and downstream compoundsbravo. youre right, i should have looked at those; it was late. i guess i just cant be persuaded because ive tried both forms extensively. the fact that high doses of nalt messed with my bowels supports those studies, as unabsorbed substances can do that, but i have to set my gaze to a study that hasnt been performed yet; for all we know, more is excreted with nalt because peak cellular amounts are achieved more rapidly with much less, which no blood reading can attest to.
While yohimbe and yohimbine aren't synonymous, I would not advise tyrosine with alphamine concurrently. You can certainly take it at a different time of day thoughHey mr cooper- I take tyrosine. Is it ok with my alphamine? I noticed that you mentioned avoiding yohimbine.
i am looking for all of those things, actually.What are you trying to achieve? What are your goals? Help with sleep? Reducing anxiety? Growth hormone secretion? Deeper sleep? Dopamine or well being? Happiness/help depression??