CoQ10

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    CoQ10


    I had picked up some CoQ10 (Ubquionine) today hearing that it has benefits for cellular energy and BP etc. I was wondering if anyone has any experience using this and can attest to its effectiveness...Thanks in advance..

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    Quote Originally Posted by mcc23 View Post
    I had picked up some CoQ10 (Ubquionine) today hearing that it has benefits for cellular energy and BP etc. I was wondering if anyone has any experience using this and can attest to its effectiveness...Thanks in advance..
    It's a blood thinner.
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    i used it to lower bp on my last cycle...
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    Quote Originally Posted by hvactech View Post
    i used it to lower bp on my last cycle...
    How well did it work? What was it before and after?
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    Quote Originally Posted by wicked442 View Post
    How well did it work? What was it before and after?
    i just went off "feeling" but my headaches went away at the same time i started it..
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    Cool. Thats what im after. Having headaches from dbol at times.
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    I thought headaches were from low BP...?
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    Any performance benefits?
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    bump
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    Theres a good write up floating around with all kinds of benefits.....
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    Quote Originally Posted by mcc23 View Post
    Any performance benefits?
    Boost energy, endurance, and help you recover faster.
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    For BP there are a lot cheaper and just as effective options

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    Quote Originally Posted by mw1 View Post
    For BP there are a lot cheaper and just as effective options
    The only subset of pathological HTN for which coenzyme q10 has shown any use is the exceptional minority whose elevated BP is the result of rampant superoxide radicals and subsequent NO-inactivation. Even so, large clinical studies have shown no significant benefit.

    Google scholar: "Study of coenzyme Q10" author:Yamagami
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    Quote Originally Posted by mw1 View Post
    For BP there are a lot cheaper and just as effective options
    Like?
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    Quote Originally Posted by hvactech View Post
    Like?
    lower dosed Hawthorn with Celery seed Extract

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    Quote Originally Posted by lronFist View Post
    The only subset of pathological HTN for which coenzyme q10 has shown any use is the exceptional minority whose elevated BP is the result of rampant superoxide radicals and subsequent NO-inactivation. Even so, large clinical studies have shown no significant benefit.

    Google scholar: "Study of coenzyme Q10" author:Yamagami
    Thanks - More reason no to buy it. CoQ10 and SAMe are both over rated ingreds IMO. The benefits of both don't justify the cost

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    I read that, good article for sure. I even picked up a book on CoQ10, interesting information on electron transporter and potent antioxidant.
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    COQ10 supplementation in healthy individuals is a lot like PQQ supplementation: largely worthless
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    Quote Originally Posted by mr.cooper69 View Post
    COQ10 supplementation in healthy individuals is a lot like PQQ supplementation: largely worthless
    If one did supplement it, doesn't it take like 2-3 months to start seeing/getting the benefits since its the only antioxidant we internally synthesize?
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    Quote Originally Posted by Bamski View Post
    If one did supplement it, doesn't it take like 2-3 months to start seeing/getting the benefits since its the only antioxidant we internally synthesize?
    Sure, but do you have reason to believe that you have a CoQ10 deficiency?
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    Quote Originally Posted by mr.cooper69 View Post
    Sure, but do you have reason to believe that you have a CoQ10 deficiency?
    Coop clean ur inbox lol
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    Quote Originally Posted by Bamski View Post
    If one did supplement it, doesn't it take like 2-3 months to start seeing/getting the benefits since its the only antioxidant we internally synthesize?
    It's not the only antioxidant humans synthesize (i.e. glutathione peroxidase, catalase, ALA, SOD, et cetra).
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    Quote Originally Posted by mr.cooper69 View Post
    Sure, but do you have reason to believe that you have a CoQ10 deficiency?
    Age?



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    Quote Originally Posted by lronFist View Post

    It's not the only antioxidant humans synthesize (i.e. glutathione peroxidase, catalase, ALA, SOD, et cetra).
    Enzymes that can act as antioxidants. I'm talking about the only lipid soluble antioxidant.

    Coop, not saying I believe I have a deficiency, I know it's expensive. Just asking haha
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    Quote Originally Posted by Admin View Post
    Age?
    To maximize your cardiovascular health, cognitive functions, cellular health and energy production after the age of 40, Robert J. Barry, Ph.D., former principle adviser for the National Institutes of Health and scientific authority on CoQ10, recommends starting at 200 to 300 mg per day for three weeks -- the length of time it takes to achieve plasma plateau. After three weeks, a daily amount of 50 to 100 mg tends to be a good daily maintenance dose for most individuals.
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    Quote Originally Posted by Ballesteri View Post
    To maximize your cardiovascular health, cognitive functions, cellular health and energy production after the age of 40, Robert J. Barry, Ph.D., former principle adviser for the National Institutes of Health and scientific authority on CoQ10, recommends starting at 200 to 300 mg per day for three weeks -- the length of time it takes to achieve plasma plateau. After three weeks, a daily amount of 50 to 100 mg tends to be a good daily maintenance dose for most individuals.
    After 40, I'd rather take Ubiquinol.



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    Quote Originally Posted by Admin View Post
    After 40, I'd rather take Ubiquinol.
    THE BASICS: Ubiquinol is a reduced, more bioavailable form of coenzyme Q10 (CoQ10), a substance produced by the human body that's necessary for the basic functioning of cells. HEALTH BENEFITS: When we’re young, ubiquinol is the predominant form of CoQ10 in nearly every cell in our bodies. As we get older, our ability to efficiently produce both CoQ10 and its electron-rich ubiquinol form declines. This results in less cellular energy and diminished protection against oxidation, which can lead to cellular damage. CoQ10 levels tend to be low in patients with certain chronic conditions, including heart disease, cancer, Parkinson’s disease, and diabetes. Statin drugs may also lower CoQ10 levels.Ubiquinol has been known to scientists since in the late 1950s. Research on ubiquinol appeared in scientific journals throughout the ’70s, ’80s, and ’90s, even though large quantities weren't commercially available. These early studies provided evidence of the critical roles ubiquinol plays in the production of cellular energy and protection against oxidative damage to DNA. Newer studies show that ubiquinol may benefit cardiovascular, neurodegenerative, and mitochondrial disorders; diabetes; periodontal disease; and hypertension.WHAT YOU SHOULD TAKE: A review of the studies published to date consistently shows that, in comparison to conventional CoQ10, supplementation with ubiquinol results in increased bioavailability and higher cellular ubiquinol levels. Ubiquinol has only recently become available in large quantities in supplement form. The recommended dosage is typically 50—100 mg daily, taken with food, preferably with fat.- Robert J. Barry, Ph.D., former principle adviser for the National Institutes of Health
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    Age, statin-use, or pathology in energy production are valid reasons to use ubiquinol. I don't understand why one would ever load CoQ10 then taper down to a maintenance dose. Longterm studies show adequate retention, and plus, it's still endogenously synthesized irrespective of dietary intake.
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    Age and statin use which describes half the US population at this point.



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    Quote Originally Posted by Bamski View Post
    Enzymes that can act as antioxidants. I'm talking about the only lipid soluble antioxidant.
    ALA is not an enzyme and it is lipid soluble (its amphipathic, actually).
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    Quote Originally Posted by Admin View Post
    Age and statin use which describes half the US population at this point.
    But not half the AM population
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    Quote Originally Posted by mr.cooper69 View Post
    But not half the AM population

    You would be surprised



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    A Supplement Everyone Over 30 Should be Taking

    As our bodies age, CoQ10 production is significantly reduced



    CoEnzyme Q10, also known as CoQ10, is a lipid-soluble compound that is needed for energy throughout the entire body. But your body’s natural production declines with age and a deficiency of this nutrient could cause a myriad of health complications.
    Found in the body’s “cellular power plants” known as mitochondria, the presence of CoQ10 is required for the healthy production of adenosine triphosphate (ATP). This tricky process occurs via aerobic cellular respiration, a key metabolic process your body uses to create energy.
    Since roughly 95 percent of your body’s energy is supplied this way, CoQ10’s role in efficiently generating ATP, and therefore the energy your body needs, is critical.
    In the human body, the highest concentrations of CoQ10 can be found in the organs with the highest energy requirements, such as the heart, brain and liver.
    What Can CoQ10 Do for You?

    CoQ10 supports every muscle contraction, your immune system, as well as every bit of energy production sourced from metabolic processes. Additionally, CoQ10 offers your body powerful antioxidant protection. It possesses the ability to transport electrons, thereby protecting your cells from damaging free radicals.
    Should You Take a CoQ10 Supplement?

    Since CoQ10 levels can be compromised by so many factors, it is advised that people over the age of 30 take a CoQ10 supplement. As we age, CoQ10 production is reduced significantly and it is believed that by the age of 80, our CoQ10 levels can be lower than they were at birth.
    Certain lifestyle factors or health concerns create a need for higher CoQ10 levels such as being a high-performance athlete, being a heart attack survivor or taking statin drugs.
    How Much CoQ10 Should You Take?

    Studies involving CoQ10 have used doses ranging from 30 mg to 1,200 mg. The general guideline is to take 1 mg per pound of body weight. So someone who weighs 150 lbs. would supplement with 150 mg of CoQ10. However, proper CoQ10 supplementation is dependent upon many factors. Here are some more specific guidelines you can reference and discuss with your physician.
    Health Concern or Objective CoQ10 mg/day
    Statin drug use 200-300 mg/day depending on statin dosing
    Improved athletic performance 60mg/day
    Reduce fatigue 50-150 mg/day
    Migraine headache sufferers 100-150 mg/ day
    Congestive heart failure 50 to 300 mg/ day
    High blood pressure 50 to 150 mg/ day
    Post heart attack 120-200 mg/day
    Huntington’s disease 600mg/ day
    Parkinson’s disease 500-1200 mg
    Why Do I Need More CoQ10 If I’m On a Statin Drug?

    Statin drugs inhibit the rate-limiting enzyme of the mevalonate pathway, HMG-CoA reductase. While this is effective for reducing the amount of cholesterol your body produces, it also interrupts some of your body’s natural functions, such as the production of CoQ10. This dramatic drop in CoQ10 can lead to fatigue, muscle aches and weakness.
    Dietary CoQ10 can be obtained from organ meats and fatty fish such as salmon. However, most of the body’s CoQ10 comes from its own production, so be sure to meet your micronutrient needs and discuss any CoQ10 limiting medications with your physician. If you want to ensure that your CoQ10 levels stay optimal as you age, your best bet is to take a CoQ10 supplement.- By Casie Terry Mace, Certified Nutrition Counselor and an American Association of Nutritional Counselors (AANC) professional member.
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    Quote Originally Posted by lronFist View Post

    ALA is not an enzyme and it is lipid soluble (its amphipathic, actually).
    I believe you are taking things out of context. I know ALA is not an enzyme obviously...ALA is fatty acid that exists in the mitochondria and is involved in energy metabolism, gives a short but potent reduction of oxidation by increasing anti-oxidant enzymes... Which is the first 2 enzymes you've listed...
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    Quote Originally Posted by Bamski View Post
    I believe you are taking things out of context. I know ALA is not an enzyme obviously...ALA is fatty acid that exists in the mitochondria and is involved in energy metabolism, gives a short but potent reduction of oxidation by increasing anti-oxidant enzymes... Which is the first 2 enzymes you've listed...
    You keep backtracking. First you said coq10 was the only endogenous antioxidant (post 21). It's not.

    You then said you were talking about antioxidants which were not enzymes and were lipid soluble. ALA is not an enzyme and is also lipid soluble.

    Although it does participate in reductive enzymatic processes, ALA itself is an antioxidant and exists in far more places then just the mitochondria (plasma, cystosol).

    Feel free to keep digging yourself a hole.
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    I'm not digging myself in a hole. CoQ10 is the only lipid soluble antioxidant synthesized in the body. I added that in my second post to clear it up but then you interpreted it the wrong way. By all means I'm not trying to start anything on here because its pointless but I was trying to clear it up, which obviously I didn't.
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    Quote Originally Posted by Bamski View Post
    I'm not digging myself in a hole. CoQ10 is the only lipid soluble antioxidant synthesized in the body.
    Once again, ALA is lipid soluble and is endogenously synthesized from octanoic acid.
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    Quote Originally Posted by lronFist View Post

    Once again, ALA is lipid soluble and is endogenously synthesized from octanoic acid.
    I understand that, but now this is getting repetitive. You told me ALA is amphipathic, water and fat soluble, yes. Not going against what your word is. i know its jumbled up but thats what ya get when I'm responding on my phone. Plus, I'm talking about solely lipid soluble. I've read up about CoQ10 because my father is deficient and it helps with heart failure due to its role as an ETC and potent antioxidant. I appreciate you trying to shed light on the matter and help with the knowledge, but my question was answered.
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