PES Enhanced profile
- 02-28-2013, 02:20 AM
- 02-28-2013, 02:43 AM
- 02-28-2013, 02:54 AM
You are his boss, right? That Doctor's office must get awfully busy...PES Representative
02-28-2013, 02:57 AM
02-28-2013, 08:56 AM
02-28-2013, 10:09 AM
For anyone thats interested(like me) here is a good write-up on swertia and its xanthones describing some very brief pharmacological activities, citing very old papers from the 70s and 80s. Turns out this stuff is not very popular outside east Asia.
I dont have 150 posts so i cannot post references.
For sweroside and gentiopicroside hepatoprotective activities have been reported and both compounds are being used as antihepatitis drugs.Possibly insulin-mimetic or beta adrenergicXanthones (especially mangiferin) are reported to give CNS stimulation . They should also have anti-inflammatory activity.
Mangiferin was the first xanthone to be investigated pharmacologically and has been found to exhibit a broad spectrum of biological activities. It shows monoamine oxidase inhibition, cardiotonic, convulsant and choleretic activities.
Some xanthones are inhibitory.1,8-Dihydroxy-3,5-dimethoxyxanthone (swerchirin), isolated from the hexane fraction of Swertia chirayita, has a very significant blood sugar lowering effect in fasted, fed, glucose loaded and tolbutamide pre-treated albino rats.
And ofc:Xanthones of S. chirayita are reported to produce CNS depression.
I actually read this paper, it was an old japanese study from the 80s testing the mutagenic potential of Swertia xanthones using Ames test. Long story short all xanthones showed mutagenic potential on rat? liver cells. Not to be alarmed though, quercetin is one of the most potent mutagens using the same test. Results have not been replicated in vivo. Besides, several xanthones and quercetin aswell have shown anti-carcinogenic potential.The extract of most of Swertia species showed mutagenic activities.
The genus Swertia exhibit variety of biological activity such as hepatoprotective, antihepatotoxic, antimicrobial, anti-inflammatory, anticarcinogenic, antileprosy, hypoglycemic, antimalarial, antioxidant, anticholinergic, CNS depressant and mutagenicity.
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