versa 1 semi fasted

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    versa 1 semi fasted


    I saw in a thread where cooper69 dosed it in a fasted state. i tried this yesterday, although i wasnt fasted, i was well below my normal caloric intake before i worked out. man, does this stuff make me sweat!!!! anybody else experience this?
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    Yup. I experience a noticeable rise in body temperature most of the time. The strength of this effect usually depends on how empty my stomach is.
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    Emptier stomach=more sweating?
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    Quote Originally Posted by jswain34 View Post
    Emptier stomach=more sweating?
    In my experience, it usually does. The effect varies for me quite a bit, which might have something to do with what and when I've eaten prior.
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    As soon as mine comes in I'm going to try fasted cardio with it. I love getting a good sweat first thing in the morning.
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    had a little more food in me today at the gym and experienced minimal sweating
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    This is a pretty interesting phenomenon to me. Any idea of what causes this fellas?
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    Quote Originally Posted by jswain34 View Post
    This is a pretty interesting phenomenon to me. Any idea of what causes this fellas?
    The increased thermo response?
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    Quote Originally Posted by R1balla View Post
    I saw in a thread where cooper69 dosed it in a fasted state. i tried this yesterday, although i wasnt fasted, i was well below my normal caloric intake before i worked out. man, does this stuff make me sweat!!!! anybody else experience this?
    I dosed fasted on non-workout days. Never noticed anything too crazy in that department but I'm usually a sweaty mess so I'm not the ideal person to ask.

    Guess I'm saying, just bc you don't "feel" it, doesn't mean it isn't working.
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    Quote Originally Posted by R1balla View Post
    had a little more food in me today at the gym and experienced minimal sweating
    Lipolysis is blunted by carbohydrates consumption (well Insulin release)...

    it makes sense...
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    Quote Originally Posted by USPlabsRep View Post
    Lipolysis is blunted by carbohydrates consumption (well Insulin release)...it makes sense...
    More specifically, AMP is high in a fasted state. and thermogenesis via the last step in oxidative phosphorylation is stimulated by an increase in AMP/fall in ATP at the level of phosphofructokinase-1. This same step is also stimulated by glucagon/epinephrine and inhibited by insulin vicariously through fructose-6-phosphate/fructose-2,6-bisphosphate.
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    Quote Originally Posted by Distilled Water View Post

    The increased thermo response?
    Yah. How more fasted=more thermo response. I understand the whole insulin/lipolysis situation. But lipolysis always correlate with sweating, does it?
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    Quote Originally Posted by USPlabsRep View Post
    Lipolysis is blunted by carbohydrates consumption (well Insulin release)...

    it makes sense...
    Sure does. The greater the expression of macronutrients during exercise, the greater the inhibition of intra-exercise fat oxidation. In other words, in non-fasted training states, hormone sensitive lipase (HSL) activity is blunted, as intramyocellular triacylglycerol (IMTG) recruitment as an energy substrate during exercise is highly expressed during fasted, but not non-fasted, states.

    In particular, intra-exercise degradation of IMTGs - [IMTGs are, by the way, accumulated as lipid droplets in skeletal-muscle cytoplasm in the vicinity of the mitochondria, the site for free fatty acid metabolism and release via hydrolysis] - is mediated by the enzyme HSL, a cyclic-AMP-mediated neutral triacylglycerol lipase that cleaves the first and second fatty acids from the glycerol backbone and constitutes the rate-limiting step in lipolysis/IMTG hydrolysis [as it cleaves fatty acids and is regulated by intramuscular (contraction) and extra-muscular (epinephrine) factors]. More specifically, in this initial step, the hormonal activation of adenylate cyclase triggers elevated cyclic AMP and cyclic-AMP-dependent protein kinase activity, stimulating the downstream phosphorylation and activation of HSL. Fatty acids released from IMTGs into the cytoplasm are transported to the outer mitochondrial membrane. In the outer mitochondrial membrane, these fatty acids are enzymatically converted to fatty acid carnitine via binding with CoA, are channeled across the mitochondrial membranes to be metabolized in the beta-oxidation pathway in the mitochondria, generating NADH, FADH2, and acetyl-CoA [ultimately metabolized in the tricarboxylic pathway to synthesize ATP via oxidative phosphorylation].
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    Quote Originally Posted by jswain34 View Post

    Yah. How more fasted=more thermo response. I understand the whole insulin/lipolysis situation. But lipolysis always correlate with sweating, does it?
    To an extent. The absence in insulin amplifies the affects of almost everything. In some simple terms, whether it be your coffee black vs. cream & sugar. Alcohol on the rocks vs. a jack & coke (regular not diet) you feel the affects faster & "harder" when there's no insulin.

    Add the fact you're coming from a faster state and its more intense. I notice the affects of coffee like its crack when I'm on a pure keto. One cup gets me running around at hyper speed.
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