How does Methyl Synephrine differ from Synephrine HCL?

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    How does Methyl Synephrine differ from Synephrine HCL?


    Which is better to take pre cardio or pre workout to enhance fat loss? Looking forward to my next recomp, just wondering which if either would be better to use.

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    Methyl Synephrine is 100000x better than regular synephrine.

    The addition of the methyl group on the alpha carbon of synephrine GREATLY changes the pharmacokinetics of the compound, its apples to oranges compares to regular synephrine.

    MS + Caffeine is seriously almost like running EC stack.
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    So if I am dosing 300mg caff preworkout right now, how would that change if adding your MS to the mix?
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    Quote Originally Posted by AZMIDLYF View Post
    So if I am dosing 300mg caff preworkout right now, how would that change if adding your MS to the mix?
    More stimulation, better fat loss from beta adrenergic activation, etc.

    It's extremely cheap & effective
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    Misunderstood my question but those will be appreciated effects for sure. How much MS would you dose with the 300mg of caff or would you pull back the caff dose and then add the MS?
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    I heard people don't "feel" stimulated from MS....
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    Quote Originally Posted by kevinhy View Post
    Methyl Synephrine is 100000x better than regular synephrine.

    The addition of the methyl group on the alpha carbon of synephrine GREATLY changes the pharmacokinetics of the compound, its apples to oranges compares to regular synephrine.

    MS + Caffeine is seriously almost like running EC stack.
    Kinetically they are actually very similar, but the b-receptor binding affinity for MS en vivo is much greater than that of synephrine. Synthetic supplements MS is a great addition to caffeine and really second only to EC stack, due to lower potency and lack of CNS penetration on the part of MS.
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    Quote Originally Posted by AaronJP1 View Post
    I heard people don't "feel" stimulated from MS....
    It is not a CNS stimulant since it cannot penetrate the BBB. That does not mean it is not exerting lipolytic, and even ergogenic, effects.
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    Quote Originally Posted by AZMIDLYF View Post
    Misunderstood my question but those will be appreciated effects for sure. How much MS would you dose with the 300mg of caff or would you pull back the caff dose and then add the MS?
    Try 200mg caffeine with 120mg MS.
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    Quote Originally Posted by mr.cooper69 View Post
    Try 200mg caffeine with 120mg MS.
    This I can do!! Thx
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    Quote Originally Posted by mr.cooper69

    Try 200mg caffeine with 120mg MS.
    I've been dosing 30mg pre workout with 100mg caffeine and 1 AT2, is the MS too low to be effective?
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    Quote Originally Posted by Austinmck17 View Post
    I've been dosing 30mg pre workout with 100mg caffeine and 1 AT2, is the MS too low to be effective?
    The effects are dose-dependent but I'd like to see you get at least 60mg since that is the studied low-dose in the therapeutic window.
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    Quote Originally Posted by mr.cooper69

    The effects are dose-dependent but I'd like to see you get at least 60mg since that is the studied low-dose in the therapeutic window.
    okay gonna up it pre-cardio Friday. gonna do 100/60/1t2. I'm using these with dermatherm to help get cut before my upcoming cycle
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    Quote Originally Posted by AaronJP1 View Post
    I heard people don't "feel" stimulated from MS....
    I don't "feel" it at the recommended dose as far as a stim feeling one would feel from something like EC or Dexaprine. Doesn't mean it isn't working, just not something I've "felt" as in feeling your on a stim.

    But I haven't experimented big time with it and definitely not over the one pill. Might need to do that
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    Quote Originally Posted by mr.cooper69 View Post
    Try 200mg caffeine with 120mg MS.
    Could the MS dose be added to a serve of Focus XT, caffeine included option?
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    Quote Originally Posted by Jag View Post
    Could the MS dose be added to a serve of Focus XT, caffeine included option?
    Of course!
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    Synephrine = great

    MethylSynephrine = great with a side of awesome sauce.


    Definitely feels more potent at a lower dose.
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    Quote Originally Posted by bioman View Post
    Synephrine = great

    MethylSynephrine = great with a side of awesome sauce.


    Definitely feels more potent at a lower dose.
    p-Synephrine (the natural alkaloid) is completely bunk. m-Synephrine is a potent alpha-adrenergic agonist, but is not natural.

    Here is a pharmacology article on "synephrine": hightowerpharmacology. blogspot. com/2011/06/p-synephrine.html

    Alpha-methylsynephrine has potential as a beta-agonist, however there is no evidence that this compound exists on the supplement market. It has a very short half-life and would need to be dosed high, and frequently, for any effect. It is vastly inferior to ephedrine.

    The Chinese refer to beta-methoxy-synephrine as "methylsynephrine" and supplement companies take advantage of this fact and are happy to provide a (completely irrelevant) COA. Beta-methoxy-synephrine is completely inert and would only provide effect from placebo.
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    Well, its either an incredible placebo or the products are something else entirely. I was introduced to it in a stim product not knowing anything about it, so I doubt its all in my head or the head of others.

    Internet chemists have been known to be wrong.
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    Quote Originally Posted by bioman View Post
    Well, its either an incredible placebo or the products are something else entirely. I was introduced to it in a stim product not knowing anything about it, so I doubt its all in my head or the head of others.

    Internet chemists have been known to be wrong.
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    I just finished a bottle of Methyl-syn and loved it. Most days I dosed 200mg caffiene + 60mg Methyl-syn upon waking then about 6hrs later 100mg caffiene + 120mg methyl syn along with ALCAR and TTA with each of those two doses and in the the evening. Great stack, great stack.
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    Quote Originally Posted by bioman View Post
    Well, its either an incredible placebo or the products are something else entirely. I was introduced to it in a stim product not knowing anything about it, so I doubt its all in my head or the head of others.

    Internet chemists have been known to be wrong.
    Never underestimate the power of placebo.
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    sciencedaily. com/releases/2012/12/121218121259.htm
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