CLA and its implications on health

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    CLA and its implications on health


    Trans-10,cis-12-CLA-caused lipodystrophy is associated with profound changes of fatty acid profiles of liver, white adipose tissue and erythrocytes in mice: possible link to tissue-specific alterations of fatty acid desaturation.

    Abstract
    Dietary supplementation with conjugated linoleic acid (CLA) has been shown to reduce body fat mass. To investigate the effects of individual CLA isomers on the fatty acid profiles of lipogenic (liver and white adipose) and lipid sensitive (erythrocyte) tissues, BALB/c mice were fed with 1 of 2 diets supplemented with either a c9,t11-CLA-enriched and t10,c12-CLA-free or a CLA-mixture containing both isomers in equal amounts (1% w/w of the diet) for 5 weeks. A control group was fed with a diet enriched in sunflower oil to energy balance the CLA. Compared to the t10,c12-CLA-free and the control diets, we observed a significant reduction of adipose tissue accompanied by fatty livers in the CLA-mix-fed group. These alterations in body fat distribution entailed a conspicuous shift of the fatty acid profiles of adipose tissue and livers. Liver enlargement was mainly caused by accumulation of C18 monoenes that accounted for 67 1% of total fatty acid methyl esters. The significant reduction of the 18:0/18:1 desaturation index in the liver upon CLA-mix diet indicated high stearoyl-CoA desaturase activity. In contrast, reduction in white adipose tissue was largely driven by percental reduction of monounsaturated fatty acids (p ≤ 0.001). 16:0/ 16:1 and 18:0/18:1 desaturation indices for white adipose tissue significantly increased, suggesting an inhibition of stearoyl-CoA desaturase upon CLA-mix diet. The fatty acid profile of the erythrocytes widely reflected that of livers, depending on the supplemented diet. These profound changes in fatty acid composition of lipogenic organs due to t10,c12-CLA intake may be the consequence of functional alterations of lipid metabolism.



    PMID: 20924169
    "The only good is knowledge and the only evil is ignorance." - Socrates

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    Good to have you back dude, and yeah, this is one reason I am wary of CLA and wish companies would disclose the specific isomer they use, if any. Not that I use it (although people mistakenly assume it is ineffective).
    http://pescience.com/
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    The above is my own opinion and does not reflect the opinion of PES
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    Quote Originally Posted by mr.cooper69 View Post
    Good to have you back dude, and yeah, this is one reason I am wary of CLA and wish companies would disclose the specific isomer they use, if any. Not that I use it (although people mistakenly assume it is ineffective).
    Thanks for the welcome.. been a hell of a couple months for me. Anyway, can you get PMID: 22452730?
    "The only good is knowledge and the only evil is ignorance." - Socrates
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    Quote Originally Posted by JudoJosh View Post
    Thanks for the welcome.. been a hell of a couple months for me. Anyway, can you get PMID: 22452730?
    Unfortunately I graduated and my school's subscription to all free texts has expired. Fortunately, I get new and even better access in < 1 week
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES
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    Overall I am now even more hesitant to use CLA. Before it was because I had doubts over its effectiveness but considering the above I would just stay away
    "The only good is knowledge and the only evil is ignorance." - Socrates
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    Hey guys, is it possible in layman's terms?
    Cheers.
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    Quote Originally Posted by redms View Post
    Hey guys, is it possible in layman's terms?
    Cheers.
    CLA caused lipodystrophy which is a redistribution of fat. The above makes it seem that CLA may help to eliminate adipose fat it isnt truly getting rid of it and just moving it to our lipogenic organs such as the liver.
    "The only good is knowledge and the only evil is ignorance." - Socrates
  

  
 

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