*Warning* D-Serine --> ALS???
- 07-24-2012, 02:23 AM
*Warning* D-Serine --> ALS???
Just asked the university to pick me up this article: d-Amino acid oxidase controls motoneuron degeneration through d-serine
Seems like D-Serine is seen elevated in ALS patients. Might not want to take D-Serine powder....
- 07-24-2012, 05:09 AM
All I've gathered from this is that one should not supplement D-serine if their D-amino Oxidase gene is non functional. This is quite obvious since DAO is implicated in D-serine degradation.
- 07-24-2012, 02:02 PM
07-24-2012, 02:48 PM
07-24-2012, 02:59 PM
07-24-2012, 03:02 PM
07-24-2012, 03:03 PM
07-24-2012, 03:09 PM
"Our data highlight the pathologic relevance of D-serine increase
derived from reduced DAO activity in ALS. Using inbred mice
lacking DAO activity, we provide evidence that loss of DAO
activity triggers motoneuron degeneration. Moreover, using
biochemical assays and sensitive quantitative methods to detect
DAO activity and D-amino acids in the tissues, we have shown
that (i) DAO activity is drastically suppressed in reactive astrocytes
of the reticulospinal tract of mSOD1 mice, (ii) decreased
degradation due to DAO inactivation contributes dominantly to
the increase of D-serine, and (iii) the reduction of DAO activity
is caused by progressive repression of DAO gene expression that
mediates the NMDAR/ERK pathway."
"In conclusion, this study provides a unique understanding of
the role of DAO and D-serine in motoneuron physiology as well
as in ALS pathophysiology as a putative enhancer of motoneuron
excitability. Our data also stress the potential use of regulators
of DAO activity or D-serine antagonists as a therapeutic
strategy in ALS."
They are saying that D-serine levels may be elevated in individuals with ALS as a result of reduced DAO activity. They are in no way saying that taking D-serine is going to cause ALS in a normal individual.
07-24-2012, 04:00 PM
07-24-2012, 04:36 PM
07-24-2012, 04:47 PM
07-24-2012, 05:13 PM
07-24-2012, 05:54 PM
07-24-2012, 07:33 PM
http://www.ingentaconnect.com/conten...00000007/005aj let me know and Ill pm you my email. Thanks.
07-25-2012, 12:39 AM
Nope, sorry. I used to have access to Northwestern's database, but the person changed their password finally after 6 years. Those ****ers have everything!
08-22-2012, 08:09 AM
08-22-2012, 08:42 AM
What if your creatinine levels are low? My levels came back low for the second time in a row and the doctor is not concerned. My thought is that if levels are high it's an indicator of possible kidney disease what do low levels mean, efficient? I would think that base line numbers mean efficiency. If you can point me in the right direction I'd appreciate it.Originally Posted by Patrick Arnold
08-22-2012, 08:55 AM
08-22-2012, 10:41 AM
Didn't pick up on the joking thing...Doc's no help and all that comes up on google are mostly wiki links that have limited info
Thought i'd try and see if you had an article or a data base link that discusses the impact of creatinine levels.
08-22-2012, 02:10 PM
08-22-2012, 02:11 PM
08-23-2012, 11:16 AM
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