*Warning* D-Serine --> ALS???

  1. *Warning* D-Serine --> ALS???


    Just asked the university to pick me up this article: d-Amino acid oxidase controls motoneuron degeneration through d-serine

    Seems like D-Serine is seen elevated in ALS patients. Might not want to take D-Serine powder....


  2. All I've gathered from this is that one should not supplement D-serine if their D-amino Oxidase gene is non functional. This is quite obvious since DAO is implicated in D-serine degradation.
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    The above is my own opinion and does not reflect the opinion of PES

  3. Quote Originally Posted by mr.cooper69 View Post
    All I've gathered from this is that one should not supplement D-serine if their D-amino Oxidase gene is non functional. This is quite obvious since DAO is implicated in D-serine degradation.
    That's what I took from the abstract as well. But I want to know what the full article has to say. I can post it when I get it if you would like.
    •   
       


  4. Do it for the general public, im always interested in learning new stuff

  5. Will do. I will try and get it up by the end of the week =)

  6. nice

  7. Thanks man, abstract gives only so much.

  8. "Our data highlight the pathologic relevance of D-serine increase
    derived from reduced DAO activity in ALS. Using inbred mice
    lacking DAO activity, we provide evidence that loss of DAO
    activity triggers motoneuron degeneration. Moreover, using
    biochemical assays and sensitive quantitative methods to detect
    DAO activity and D-amino acids in the tissues, we have shown
    that (i) DAO activity is drastically suppressed in reactive astrocytes
    of the reticulospinal tract of mSOD1 mice, (ii) decreased
    degradation due to DAO inactivation contributes dominantly to
    the increase of D-serine, and (iii) the reduction of DAO activity
    is caused by progressive repression of DAO gene expression that
    mediates the NMDAR/ERK pathway."

    "In conclusion, this study provides a unique understanding of
    the role of DAO and D-serine in motoneuron physiology as well
    as in ALS pathophysiology as a putative enhancer of motoneuron
    excitability. Our data also stress the potential use of regulators
    of DAO activity or D-serine antagonists as a therapeutic
    strategy in ALS."

    They are saying that D-serine levels may be elevated in individuals with ALS as a result of reduced DAO activity. They are in no way saying that taking D-serine is going to cause ALS in a normal individual.
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  9. Correct, but could an abundance of D-Serine reduce DAO activity?

    Courtesy of PHF (henryv): http://www65.zippyshare.com/v/25574568/file.html

  10. Quote Originally Posted by mr.cooper69 View Post
    All I've gathered from this is that one should not supplement D-serine if their D-amino Oxidase gene is non functional. This is quite obvious since DAO is implicated in D-serine degradation.
    ^ This.

    Quote Originally Posted by Aleksandar37 View Post
    They are saying that D-serine levels may be elevated in individuals with ALS as a result of reduced DAO activity. They are in no way saying that taking D-serine is going to cause ALS in a normal individual.
    ^ This.

    Quote Originally Posted by qwick View Post
    Courtesy of henryv you mean.
    Antus Labs rep

  11. Quote Originally Posted by qwick View Post
    Correct, but could an abundance of D-Serine reduce DAO activity?

    Courtesy of PHF: http://www65.zippyshare.com/v/25574568/file.html
    DAO is going to keep doing its job until it runs out of substrate or cofactors needed for activity. An abundance of D-serine would increase overall activity. Also, please consider that this is one article and it is in PNAS, a journal with a peer review process that I don't agree with at all. Members of the NAS get a free pass.
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  12. Quote Originally Posted by henryv View Post
    ^ This.



    ^ This.



    Courtesy of henryv you mean.
    Thank you for clarifying.

    Quote Originally Posted by Aleksandar37 View Post
    DAO is going to keep doing its job until it runs out of substrate or cofactors needed for activity. An abundance of D-serine would increase overall activity. Also, please consider that this is one article and it is in PNAS, a journal with a peer review process that I don't agree with at all. Members of the NAS get a free pass.
    I am trying to read as many serine articles that i can get my hands on. Research on d serine is relatively new, so I am trying to soak up as much information as possible. If you know of any articles that range from 2010-2012 that are about serine please let me know. My universities database is weak and I have to wait for certain articles to get mailed to me =/

  13. Quote Originally Posted by qwick View Post
    Thank you for clarifying.



    I am trying to read as many serine articles that i can get my hands on. Research on d serine is relatively new, so I am trying to soak up as much information as possible. If you know of any articles that range from 2010-2012 that are about serine please let me know. My universities database is weak and I have to wait for certain articles to get mailed to me =/
    It's not really my field, except I believe they have found overactive DOA in schizophrenia. If you make a list and sent it to me with your email in a PM, I can try and find pdfs for you.
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  14. Quote Originally Posted by Aleksandar37 View Post
    It's not really my field, except I believe they have found overactive DOA in schizophrenia. If you make a list and sent it to me with your email in a PM, I can try and find pdfs for you.
    Thanks for the help, but I don't wanna bother you if you have to google dork it =) I can get most article instantly, but some of them I have to wait 2 or 3 days for. But if you could find http://www.ingentaconnect.com/conten...00000007/005aj let me know and Ill pm you my email. Thanks.

  15. Nope, sorry. I used to have access to Northwestern's database, but the person changed their password finally after 6 years. Those ****ers have everything!
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  16. Quote Originally Posted by qwick View Post
    Just asked the university to pick me up this article: d-Amino acid oxidase controls motoneuron degeneration through d-serine

    Seems like D-Serine is seen elevated in ALS patients. Might not want to take D-Serine powder....

    creatinine is elevated in kidney disease. taking creatine (which all converts to creatinine) therefore gives you kidney disease.
    Anabolicminds.com Featured Author

  17. Quote Originally Posted by Patrick Arnold

    creatinine is elevated in kidney disease. taking creatine (which all converts to creatinine) therefore gives you kidney disease.
    What if your creatinine levels are low? My levels came back low for the second time in a row and the doctor is not concerned. My thought is that if levels are high it's an indicator of possible kidney disease what do low levels mean, efficient? I would think that base line numbers mean efficiency. If you can point me in the right direction I'd appreciate it.

  18. Quote Originally Posted by JosNYC View Post
    What if your creatinine levels are low? My levels came back low for the second time in a row and the doctor is not concerned. My thought is that if levels are high it's an indicator of possible kidney disease what do low levels mean, efficient? I would think that base line numbers mean efficiency. If you can point me in the right direction I'd appreciate it.

    first of all i was joking.

    second of all i am not a doctor so i dunno what low creatinine means.

    try google?
    Anabolicminds.com Featured Author

  19. Didn't pick up on the joking thing...Doc's no help and all that comes up on google are mostly wiki links that have limited info

    Thought i'd try and see if you had an article or a data base link that discusses the impact of creatinine levels.

  20. Quote Originally Posted by JosNYC View Post
    What if your creatinine levels are low? My levels came back low for the second time in a row and the doctor is not concerned. My thought is that if levels are high it's an indicator of possible kidney disease what do low levels mean, efficient? I would think that base line numbers mean efficiency. If you can point me in the right direction I'd appreciate it.
    Low levels just mean that your kidneys are working great and you are urinating the waste out of your body. It is only a single measure to help point your physician in the direction of a problem. They were not concerned based on how everything else looked.
    ***PES Representative***
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  21. Quote Originally Posted by Patrick Arnold View Post
    creatinine is elevated in kidney disease. taking creatine (which all converts to creatinine) therefore gives you kidney disease.
    I can see this being quoted for years now lol
    ***PES Representative***
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  22. Quote Originally Posted by Aleksandar37 View Post
    Low levels just mean that your kidneys are working great and you are urinating the waste out of your body. It is only a single measure to help point your physician in the direction of a problem. They were not concerned based on how everything else looked.
    Thank you. Much appreciated.
  

  
 

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