acacia rigidula iforce maximize intense

[Afi140]

is this ingredient safe? apparently the leaf contains the ingredients below.. what did you guys extract in the new formula? looking to get away from craze due to its many sides... what can i expect from this? any help is greatly appreciated! thanks guy

nicotine???, methamphetamine, beta-methyl-phenethylamine, n-methyltryptamine,

[Whacked]

I am NOT taking a position on this subject as I have not read into this but here is some info stolen from another board...

Toxic amines and alkaloids from acacia rigidula

Acacia rigidula Benth., blackbrush, is a shrub found growing on rocky ridges in west and southwest Texas and northern Mexico. Consumption of blackbrush and a related species guajillo, Acacia berlandieri Benth., has been associated with a locomotor ataxia known as "limber leg".

A. rigidula has been shown to contain appreciable levels of toxic alkaloids. Sheep and goats grazing on a related species, Acacia berlandieri Benth., guajillo, during periods of drought in the Rio Grande Plains of Texas have developed a locomotor ataxia referred to as "guajillo wobbles" or "limber leg" [2]. Previous analysis of blackbrush had detected and identifed four amines, N-methyl-b-phenethylamine (NMPEA), tyramine, N-methyltyramine, and hordenine, which were also found in guajillo [3].

As a result of this study, an intensive chemical analysis of A. rigidula Benth. was undertaken to identify the amines and alkaloids present in the leaves and stems that would comprise browse material.

Forty-four amines and alkaloids, including the four previously encountered amines, N-methyl-b-phenethylamine, tyramine, N-methyltyramine, and hordenine, were identifed by GC-MS.

The majority of the isolated alkaloids, 18 of the 33 identifed, were related to the parent compound b-phenethylamine. These compounds generally varied in the degree of N-methylation, x-methylation (amphetamine family), and in oxygenation of the aromatic ring (tyramine, dopamine, and mescaline families). The 2-cyclohexylethylamine and the N-cyclohexylethyl-N-methylamine are the saturated analogs of the phenethylamine and NMPEA respectively. Tryptamine, N-methyltryptamine, and N,N-dimethyltryptamine were also isolated from blackbrush.

Other noteworthy alkaloids found in blackbrush include nicotine, nornicotine, and four tetrahydroisoquinoline alkaloids, anhalamine, anhalidine, anhalonidine, and peyophorine. The amides of the amino acids pipecolic acid and p-hydroxypipecolic acid were also detected.

As was previously found with NMPEA the foliage collected in the autumn contained higher quantities of amines and alkaloids [10]. There was also a distinct increase in the number and quantity of methylated analogs present (Table 1).

Several as yet unidentifed amine-containing compounds have been detected but have not yet been identifed. It is also probable that several biosynthetic precursors are present in the mixture but as yet are unresolved and are below the threshold of GC-MS detection.

Phenolic amines, as a group, impact the hypothalamic-pituitary-adrenal axis [11]. The consequent release of ACTH and cortisol results in symphathomimetic action. The number of phenolic amines reported in Table 1 and their concentrations in the plant indicate a substantial toxic load to animals consuming blackbrush. The toxicity of nicotine and nornicotine has been well established [12], as has the psychoactivity of mescaline and its derivatives. None of the compounds identifed appear to have been implicated in locomotor ataxia. However the presence of the amphetamines suggests the possibility for a reduction of monoamine oxidase activity [13]. FULL VERSION: http://www.erowid.org/archive/rhodiu...a.rigidula.pdf



Excerpts from:
Chemistry of Acacia's from South Texas

Acacia species in south Texas contain numerous chemical compounds, many of which have negative effects on animal performance.

Alkaloids, phenolic amines, phytoestrogens, and tannis have been identified in south Texas acacias.

Many of the acacias of south Texas are considered to be valuable forage for deer and domestic livestock. It is known, however, that at least one species, guajillo (Acacia berlandieri) will produce a paralytic condition in sheep and goats called "guajillo wobbles." As part of a larger study investigating the chemistry of south Texas range plants, we determined the chemical composition of the leaves of several south Texas acacias.

Most woody plants contain a variety of chemical compounds a number of which have the advantage to the plant of being toxic to animals that consume them. Many of these defensive compounds are nitrogen-based, though there also are a significant number of nonnitrogenous toxic compounds. Additionally, plants produce compounds which may be repellent or, as in the case of tannins, lower the nutritional value of the plant. Early research, using paper and thin-layer chromatographic techniques, identified several phenolic amines in A. berlandieri, including n-methyl-phenethylamine (NMP), tyramine, nmethyltyramine and hordenine.

The alkaloid fractions (those extractable with 10% HCL) of A. berlandieri and A. rigidula contained a complex mixture of alkaloids including nicotine, nornicotine, anhalamine, mescaline, and 3,4,5-trihydroxy-phenethylamine (demethylated mescaline).

The phenolic amines, such as tyramine, hordenine and N-methyl-B-phenethylamine are powerful activators of the sympathetic nervous system causing the release of cortisol and adrenocorticotropic hormone. In addition to the alkaloids, the plants were also found to contain intricate mixtures of tannins and flavenoids including catechin, fisetin and quercetin.

While tannins and their antinutritional effects have been the subject of much research in recent years, little attention has been paid to the negative effects of consumption of other secondary compounds that are not acutely toxic. However, recent research has shown the negative effects on fertility of consumption of amine-containing forage. Consumption of guajillo and blackbrush was shown to reduce fertility in male goats, and to reduce their ability to handle stressful situations such as transportation.

Table 1. Major Chemical Compounds in South Texas Acacias :

Amines and Alkaloids:

phenethylamine
N,N-dimethylphenethylamine
N,N-dimethyl-"-methylphenethylamine
p-hydroxyamphetamine
tyramine
3-5-dimethoxytyramine
3,4-dimethoxy-5-hydroxy-$-phenethylamine
hordenine
N,N-dimethyldopamine
tryptamine
N,N-dimethyltryptamine
N-methylmescaline
nicotine
anhalamine
peyophorine
nortryptyline
3-"-cumyl-1,3,4-oxadiazolidine-2,5-dione
p-hydroxypipecolamide
4-methyl-2-pyridinamine

N-methylphenethylamine
amphetamine
methamphetamine
p-methoxyamphetamine
N-methyltyramine
candicine
dopamine
N-methyldopamine
3-methoxytyramine
N-methyltryptamine
mescaline
trichocereine
nornicotine
anahalidine
mimosine (methyl ester)
musk ambrette
pipecolamide
1,4-benzezediamine


Phytoestrogens:

octylphenol \
aristolone
(Z)-9-octadecenoic acid
(Z,Z,Z)-9,12,15-octadecatrienoic acid
3b-acetoxy-17-methyl-5a-18-abeoandrost-13-ene

nonylphenol
3b-cholest-5-en-3-ol
(Z,Z)-9,12,-octadecanoic acid

FULL VERSION: http://uvalde.tamu.edu/pdf/chemtdaf.pdf

[VaughnTrue]

Or product is isolated for 3 specific isomers of PEA, and methyl synephrine. There are no toxic portions in this extract. Good to go.

[EBF Inc]

Or product is isolated for 3 specific isomers of PEA, and methyl synephrine. There are no toxic portions in this extract. Good to go.

Agreed. This is the beauty of standardized extracts. If it was a full spectrum, whacked, then issues would be had.

But nicotine eh? Some great research on that there. Neuro protective and lipolysis amongst other things

[SynergyIre]

Agreed. This is the beauty of standardized extracts. If it was a full spectrum, whacked, then issues would be had.

But nicotine eh? Some great research on that there. Neuro protective and lipolysis amongst other things

Not to go off topic, but I think this has just better explained standardized extracts for me, thanks!

So if an extract is 20% standardized, 20% of it has is a custom extract of the plant and 80% is full spectrum? To this end, I guess not all standardized extracts would be equal, kinda of like a prop blend herbs. I assume no company would claim 100% for legal reasons, so I assume that would me that any 'pure' product would be synthesized, and thus actually pure, yeah? Thanks!

[Afi140]

are any of the 3 isomers in craze? this stuff seems all too "hidden" if i must say so.... why not put all 4 ingredients that were extracted in the label and in progressive order? instead of putting them under the umbrella ingredient. I love hemavol so im not bashing... just curious as this whole craze debacle has me suspect of everything these days.

[mr.cooper69]

It is likely safe. Would be extremely stupid if iForce extracted for toxic compounds.

[Angelbolic]

I'm very impressed with I-Force's R&D departement. Not only did they find an affordable way to standarize GTE for theophylline content, they now surpassed themselves by finding an afforable way to standarize an acacia rigidula extract for specific PEAs and a compound that isn't even found in acacia rigidula. Furthermore, they also found a way to get rid of some illegal compounds found in acacia rigidula.

It's only a matter of time until Vaughn will be headhunted by Pfizer or Novartis.

[Royd The Noyd]

I'm very impressed with I-Force's R&D departement. Not only did they find an affordable way to standarize GTE for theophylline content, they now surpassed themselves by finding an afforable way to standarize an acacia rigidula extract for specific PEAs and a compound that isn't even found in acacia rigidula. Furthermore, they also found a way to get rid of some illegal compounds found in acacia rigidula.

It's only a matter of time until Vaughn will be headhunted by Pfizer or Novartis.

I bet you wear your iforce t-shirt everyday.

[VaughnTrue]

I'm very impressed with I-Force's R&D departement. Not only did they find an affordable way to standarize GTE for theophylline content, they now surpassed themselves by finding an afforable way to standarize an acacia rigidula extract for specific PEAs and a compound that isn't even found in acacia rigidula. Furthermore, they also found a way to get rid of some illegal compounds found in acacia rigidula.

It's only a matter of time until Vaughn will be headhunted by Pfizer or Novartis.

Please, test against my claims. I'll wait.

[Celorza]

I'm very impressed with I-Force's R&D departement. Not only did they find an affordable way to standarize GTE for theophylline content, they now surpassed themselves by finding an afforable way to standarize an acacia rigidula extract for specific PEAs and a compound that isn't even found in acacia rigidula. Furthermore, they also found a way to get rid of some illegal compounds found in acacia rigidula.

It's only a matter of time until Vaughn will be headhunted by Pfizer or Novartis.

oO...

[Angelbolic]

Please, test against my claims. I'll wait.

I have no financial interest in this, so why would I spend hundreds to have your product tested? Anyone with common sense knows it's highly unlikely/impossible you're using an extract. It's only a matter of time until you guys get busted again, so I guess until then you can claim whatever you want. Just don't expect everyone is stupid enough to believe your BS.

[Celorza]

I have no financial interest in this, so why would I spend hundreds to have your product tested? Anyone with common sense knows it's highly unlikely/impossible you're using an extract. It's only a matter of time until you guys get busted again, so I guess until then you can claim whatever you want. Just don't expect everyone is stupid enough to believe your BS.

wow way outta line there bubba , settle down.

[madchemist]

wow way outta line there bubba , settle down.

I fail to see where he is incorrect. Methylsynephrine is not a constituent of acacia, so it would be impossible to extract.

Furthermore, Shulgin did not believe that the greater majority of PEA derivatives listed above actually exist in Acacia spp. He believed that their presence was the result of contamination. N-methyl-PEA likely exists, however, and is mildly toxic to some mammals.

[VaughnTrue]

I fail to see where he is incorrect. Methylsynephrine is not a constituent of acacia, so it would be impossible to extract.

Furthermore, Shulgin did not believe that the greater majority of PEA derivatives listed above actually exist in Acacia spp. He believed that their presence was the result of contamination. N-methyl-PEA likely exists, however, and is mildly toxic to some mammals.

Hi-Tech Pharm is the company who was able to isolate/locate MS in acacia, and I can verify from seeing the raw material in my hand as well as seeing the COA's that it is a natural extract, and no isolated compounds.

Here is their write up on the MS portion:

Methylsynephrine -is phenolic B-Phenylethylamine found in Acacia rigidula and some cacti, which produces considerable central nervous stimulation (CNS). With Hi-Tech's research over the past five years on Acacia rigidula (as Thermo-Rx®), Hi-Tech has identified and isolated severarl key phenylethylamine alkaloids. The newest of which is methylsynephrine. The alkaloids from' Acacia rigidula are biologically and physiologically similar to those found in ephedra, and possess properties that are shared with ephedra alkaloids. Scientifically, this is in part due to the similarities in pharmacokinetics and pharmacodynamics. The most obvious similarity is that Acacia alkaloids, like the ephedra alkaloids, readily pass into the brain. The main factor governing the transfer of small molecules into the central nervous system is lipophilicity. The distribution of drugs and/or compounds into the CNS from the blood is unique, because functional barriers are present that restrict entry of drugs into this critical site. One reason for this is that the brain capillary endothelial cells have continuous tight junctions; therefore, drug penetration into the brain depends on transcellular rather than paraceuliar transport between cells. The unique characteristics of pericapillary glial cells also contribute to the blood-brain barrier. At the choroids plexus, a similar blood-cerebrospinal fluid (CSF) barrier is present, except that it is epithelial cells that are joined by tight junctions rather than endothelial cells. As a result, the lipid solubility of the nonionized and unbound species of the drug is an important determinant of its uptake by the brain; the more lipophilic it is, the more likely it is to cross the blood-brain barrier. This situation is used in drugs design to alter the brain distribution, which is the case with drugs like amphetamine, phentermine, and benzphetamine. As you can see from the comparison of the structures of ephedrine, norephedrine, and methylsynephrine they all possess the N-methyl substituent of the aliphatic sidechain, which is characteristic of ephedrine and its congeners, as well as methylsynephrine, thus further increasing lipophilicity.

[madchemist]

Hi-Tech Pharm is the company who was able to isolate/locate MS in acacia, and I can verify from seeing the raw material in my hand as well as seeing the COA's that it is a natural extract, and no isolated compounds.

Here is their write up on the MS portion:

Understand that the correct nomenclature for this compound is beta-methoxy-synephrine not "methylsynephrine."

Methylsynephrine is oxilofrine (alpha-methylsynephrine).

Beta-methoxy-synephrine will have no activity.

[VaughnTrue]

oxilofrine is considered a drug, so it will not be contained in any of our products.


While I understand exactly what you're saying, I do know however what Beta-methoxy-synephrine feels like when dosed 20-80mg. It hits, and hits hard.

I'd love to send you a sample of that pure compound for you to try out, would love to see how you react to it(if at all).

[madchemist]

oxilofrine is considered a drug, so it will not be contained in any of our products.


While I understand exactly what you're saying, I do know however what Beta-methoxy-synephrine feels like when dosed 20-80mg. It hits, and hits hard.

I'd love to send you a sample of that pure compound for you to try out, would love to see how you react to it(if at all).

I will accept the legitimacy of your claim if you first get it tested by Patrick Arnold.

While I am a fairly trusting guy, I'd prefer to know exactly what I am ingesting.

[VaughnTrue]

I will accept the legitimacy of your claim if you first get it tested by Patrick Arnold.

While I am a fairly trusting guy, I'd prefer to know exactly what I am ingesting.

I would gladly include a COA, but if PA is willing to test something for free, rock on

[madchemist]

I would gladly include a COA, but if PA is willing to test something for free, rock on

I do not know what he would charge (maybe nothing?), but I am fairly certain it would be substantially less then what chromadex would charge.

A COA is of limited value, especially considering the amount of fraudulent COAs I have observed over the years.