I've been wondering if anyone talking one of the aminos mentioned above has less muscle soreness / better regeneration.
I've been taking some supplements that heavily deplete sulfur in the body (tyrosine, to name one). I've countering sulfur depletion by taking huge amounts of MSM, which helped a lot... but... few years ago I barely got any muscle soreness, but now when I train, I get lots of it... almost every time. Since then I asked myself why I get heavy muscle soreness...
Now MSM is nothing more then a sulfur donor, but the most effective way to get sulfur in the system would be by taking cystine, because it passes the gut without being destroyed (unlike cysteine), and it does not have side effects acetyl cysteine may have. Cystine gets transformed to cysteine within the cell, and together with glutamate and glycine the cell produces ... the bodies strongest antioxidant. With MSM the body would have to produce cysteine first from the sulfur found within MSM... which it might not be able to do efficient enough.
Now while training muscle gets damaged, and I am thinking that this damage might cause massive oxidative stress that may lead to inflammation which in turn may be a part of muscle soreness... What I know from other cells like cartilage cells that the inflammation signals damaged cells send out in turn through some process ( I can't remember which one exactly) damage healthy cells nearby causing more problems. But in cartilage the metabolism is so slow that this process does not stop, in muscle tissue however metabolism is quite fast so the muscle does still regenerate. So... more oxidative stress through training = more inflammation = more damage = longer regeneration time and more stress. And inflammation = catabolic
So long story short, I think my body has not enough glutathione, and that may be the reason for the massive increase in muscle soreness.
To test the hypothesis, I've been taking acetyl-cysteine and so far I think my muscle soreness is much less...
I am wondering if anyone also noticed better regeneration / less muscle soreness through cysteine/cystine/acetylcysteine? acetyl-cysteine might be a great extra to a pre-workout drink if it indeed helps, and cystine for long term regular supplementation...
A related Study:
Severe post-exercise muscle soreness may be reduced by the amino acid N-acetyl cysteine ( ). NAC is a precursor to glutathione, the body’s primary cellular antioxidant. Scientists in Brazil studied the effect of NAC supplementation on parameters of oxidative damage and inflammatory response after high-intensity eccentric exercise (EE). Twenty-nine participants were divided randomly in three groups to take either placebo, NAC or NAC plus placebo. After taking 750 mg per day for 14 days, participants performed 3 sets at 80% of their 1-rep max until exhaustion. For the next seven days, researchers monitored muscle soreness and markers of cell damage. Only the supplemented groups maintained high levels of interleukin 10 (IL-10), an anti-inflammatory marker, on the 7th day after the workout, suggesting that treatment with NAC might prevent muscle soreness after exercise.