Nice ALA study.

  1. I am faster than 80% of all snakes
    Dwight Schrute's Avatar
    Stats
    6'1"  221 lbs.
    Join Date
    Nov 2002
    Age
    41
    Posts
    12,911
    Rep Power
    7019

    Nice ALA study.


    J Nutr 2002 Oct;132(10):3001-6 Related Articles, Links


    Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria.

    Dicter N, Madar Z, Tirosh O.

    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel.

    alpha-Lipoic acid (LA) is currently being investigated as a glucose-lowering agent for diabetes control; it is also considered a powerful dietary antioxidant. The objective of this study was to investigate the fate of glucose in isolated rat muscles incubated with LA and determine its effects on intramuscular redox status. Rat soleus muscles were incubated for up to 60 min with 2.4 mmol/L LA in the presence or absence of insulin. Intramuscular concentrations of LA were evaluated (uptake and reduction), and glycogen synthesis, glucose oxidation, intramuscular reactive oxygen species (ROS) production and mitochondrial membrane potential investigated. Insulin enhanced glycogen synthesis, whereas LA decreased rates by >50%. LA elevated ROS production and in combination with t-butylhydroperoxide, an oxidant, additively inhibited glycogen synthesis rates by 80%. Insulin acted as an antioxidant and attenuated ROS production by 30%. LA uncoupled the mitochondria and accelerated glucose oxidation 1.5-fold relative to the control. The glycogen synthesis pathway was found to be dependent on mitochondrial function because treatment with mitochondrial inhibitors eliminated the majority of glycogen synthesis. These data show that in this model, LA acts as a mild prooxidant, causing mitochondrial uncoupling and inhibition of glycogen synthesis. It appears that LA regulates glucose metabolism in the muscle differently than insulin.
    For answers to board issues, read the Suggestion and News forum at the bottom of the main page.

  2. Moderator
    WYD02's Avatar
    Join Date
    Oct 2002
    Posts
    817
    Rep Power
    557
    Level
    21
    Lv. Percent
    77.22%

    Good stuff bobo!!
  3. Advanced Member
    Sheesh's Avatar
    Join Date
    Dec 2002
    Posts
    516
    Rep Power
    405
    Level
    23
    Lv. Percent
    87.1%

    Awesome study, let's hope it applies to humans...
    •   
       

  4. forbodybuilders's Avatar
    Join Date
    Feb 2003
    Posts
    7
    Rep Power
    0
    Level
    2
    Lv. Percent
    43.33%

    bump! ALA rule!

    forbb

Similar Forum Threads

  1. Repost of an ALA article I found
    By Matthew D in forum Supplements
    Replies: 7
    Last Post: 10-30-2006, 03:12 AM
  2. Elite's Ultimate ALA Guide
    By YellowJacket in forum Supplements
    Replies: 4
    Last Post: 03-25-2003, 11:14 PM
  3. ALA, Thoughts & Experiences
    By Biggs in forum Supplements
    Replies: 17
    Last Post: 01-15-2003, 05:57 PM
  4. Nice Place you have here.
    By Bozz in forum Anabolics
    Replies: 19
    Last Post: 11-28-2002, 07:29 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in