No problem bro...
Most contract mfrs. use a variety of ways to ensure uniformity with blends, so you don't really have much to worry about. Screening/de-lumping is a must in any situation pre-production- it doesn't matter if you are doing hard shell encapsulation (what we are best at), or prepping a blend going into a tub. Lumps create all types of issues, because they add in significantly variability. They can be caused by a number of things- static electricity and moisture are two major culprits, and lumps can f-up a blend like nothing else. They can also cause rat holes in the powder- which are circular holes found in a blend- and rat holes are a sign of an inconsistent mixture, and can cause a lot of issues as well, especially when it comes to maintaining proper capsule weights. Good blend testing normally catches any issues- we use FT-NIR to test uniformity (it has an assay function)
On potent ingredients, they are normally metered out very carefully, and are pre-blended in with other excipients, so normally will be ok on that end.....