kill Fat Cells

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  1. kill Fat Cells


    Hey Guys

    I read some studies about "killing fat cells" what did you think?

    Resveratrol and Quercetin
    Enhanced inhibition of adipogenesis and induction ... [Life Sci. 2008] - PubMed result

    Quercetin and Caffeine
    Potentiation of beta-adrenoceptor agonist-mediated... [Biochem Pharmacol. 1994] - PubMed result

    CLA and l-Arginine
    Dietary Supplementation of l-Arginine and Conjugated Linoleic Acid Reduces Retroperitoneal Fat Mass and Increases Lean Body Mass in Rats ? J. Nutr.

    CLA has been shown to cause apoptosis in rats but in human??
    studies have also shown that CLA blocks the ‘fat sensor’ PPAR-gamma.

    Curcumin also inhibits the production of PPAR-gamma, the sensor that alerts fat cells to the presence of fat. If the sensor works less well, fat cells absorb less fat.

    Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice ? J. Nutr.

    Capsaicin inhibit fat cell growth?
    Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications ? Am J Clin Nutr

    Dihydrocapsiate is similar to capsaicin, which is known for its thermogenic properties
    Effect of dihydrocapsiate on resting metabolic rate in humans ? Am J Clin Nutr


  2. Thanks for posting these, Maxximal.

    I should have payed attention in school, then maybe I could understand the terminology in these studies.

  3. Quote Originally Posted by bluehealer View Post
    Thanks for posting these, Maxximal.

    I should have payed attention in school, then maybe I could understand the terminology in these studies.
    not worry here to help I`m learn somenthing new all days
    •   
       


  4. Hmmmm very interesting. I knew the goal has always been to shrink fat cells, but now it seems people are looking to just kill them!

    I think there is a phosphotidylcholine + Bile Salt product being researched right now for this by big pharma

  5. Quote Originally Posted by nattydisaster View Post
    Hmmmm very interesting. I knew the goal has always been to shrink fat cells, but now it seems people are looking to just kill them!

    I think there is a phosphotidylcholine + Bile Salt product being researched right now for this by big pharma
    Hmmmmmmm

  6. Thanks Great post!!!
    Core Nutritionals Representative

  7. Oh BTW I've always been confused how much CLA to consume. Is it 4-6g a day? Like 3 caps of 2g a day?

  8. Great info! I have run CLA in high doses (8-10g per day) for several months with no results. It's still one of those supps, like glutamine, that people think works great or doesn't work at all.

  9. Quote Originally Posted by LJ57 View Post
    Great info! I have run CLA in high doses (8-10g per day) for several months with no results. It's still one of those supps, like glutamine, that people think works great or doesn't work at all.
    I also found CLA never did anything for me.
    Core Nutritionals Representative

  10. This is a great thread. What would everyone reccomend for supps that activate the "stop it" switch on fat cells year round?

  11. Quote Originally Posted by kingdong View Post
    This is a great thread. What would everyone reccomend for supps that activate the "stop it" switch on fat cells year round?
    Something like EGCG + Glycobol + Sesamin would probably be a good stack to take year round for minimizing fat gains year-round.

  12. CLA not work 4 months in a row and nothing

  13. Quote Originally Posted by LJ57 View Post
    Something like EGCG + Glycobol + Sesamin would probably be a good stack to take year round for minimizing fat gains year-round.
    Doesn't sesamin actually reduce glycogen or something?

  14. Quote Originally Posted by luelinks View Post
    Oh BTW I've always been confused how much CLA to consume. Is it 4-6g a day? Like 3 caps of 2g a day?
    6g with food and isomer cis-9,trans-11 and trans-10,cis-12

    but looks this

    http://www.ajcn.org/content/80/3/614.abstract

  15. Quote Originally Posted by MAxximal View Post
    6g with food and isomer cis-9,trans-11 and trans-10,cis-12

    but looks this

    http://www.ajcn.org/content/80/3/614.abstract
    Yeah, cis,trans-9,11-Octadecadienoic acid is supposed to offer some cancer protection, and the trans,cis-10,12-Octadecadienoic acid is associated with fat reduction (but not in adult humans really.) I've never had much success with it from 0.5-8g/day. Kinda disappointing.

    But it has been associated with improved carcass weight parameters in neonates from prenatal exposure, with greater lean mass and smaller fat cells in the sow's adult offspring! Also shown to reduce risk of mammary cancer in matured female offspring. So if you want a healthy repartitioning result and possible anti-carcinogenic benefit that could last a lifetime in your unborn kids, you might consider suggesting it to your pregnant wives, lol. The benefit was also noted to be passed down to the offspring's offspring (2'nd and 3'rd generation), so a pretty cool potential epigenetic effect!

  16. I don't think fat cell apoptosis is a very great idea in the grand scheme of things. Fat cells are important stores to the body. Some drugs given to AIDs patients actually cause this effect and lead to something known as lipodystrophy syndrome. This is where the fat build up (which has to go somewhere if there is a calorie surplus) occurs around the neck, giving the person a hump. Not very sexy.

  17. I've been looking into PGF2a for transdermal use

  18. Quote Originally Posted by BrockR View Post
    I've been looking into PGF2a for transdermal use
    Let me save you the time and pain, literally. It does work but the pain and explosive sh*ts you get from its use will never allow anyone to use it for long enough of a period of time to really see the fat disappear.

    Ive used it and did it for more 2 weeks in total with various dosing schemes and delivery and it was HELL. Trust me its not worth it.

  19. Quote Originally Posted by Sldge View Post
    Let me save you the time and pain, literally. It does work but the pain and explosive sh*ts you get from its use will never allow anyone to use it for long enough of a period of time to really see the fat disappear.

    Ive used it and did it for more 2 weeks in total with various dosing schemes and delivery and it was HELL. Trust me its not worth it.
    He mentioned it as a trandermal.. which I have used... but without the success that pinned PGF delivers.

    I stuck it once, and never again.

  20. Quote Originally Posted by Robboe View Post
    I don't think fat cell apoptosis is a very great idea in the grand scheme of things. Fat cells are important stores to the body. Some drugs given to AIDs patients actually cause this effect and lead to something known as lipodystrophy syndrome. This is where the fat build up (which has to go somewhere if there is a calorie surplus) occurs around the neck, giving the person a hump. Not very sexy.
    Fair enough. I wonder what it is that makes the fat cells in the neck store the left over fat. Some people can eat extra callories and not store extra fat at all, so I wonder I wonder if these supplement would have similar side effects to the AIDS drugs(obviously less pronounced)


    I guess this is one of those situatons where we should be getting Dr. D or some other really smart person to come in and teach us a lesson in biology.

  21. Androgens keep fat cells small.......but in womens?

    http://www.ncbi.nlm.nih.gov/pubmed/17332526

  22. Quote Originally Posted by DAdams91982 View Post
    He mentioned it as a trandermal.. which I have used... but without the success that pinned PGF delivers.

    I stuck it once, and never again.

    Yeah, I wouldn't dream of pinning it after all I've read.

    So you're saying it's not worth pursuing the TD idea?

    If I'm not mistaken, weren't you the guy that posted about making your own local carrier for PGF?

    I've read a lot of mixed results from people using it transdermal, seems to depend a lot on the carrier used.

  23. Quote Originally Posted by BrockR View Post
    Yeah, I wouldn't dream of pinning it after all I've read.

    So you're saying it's not worth pursuing the TD idea?

    If I'm not mistaken, weren't you the guy that posted about making your own local carrier for PGF?

    I've read a lot of mixed results from people using it transdermal, seems to depend a lot on the carrier used.
    yeah, I made my own carrier... i did get results... but in hindsight it wasn't worth the cost. If you find it on the cheap, then I would maybe just take it and add it to a bottle of evicerate and see where that takes you.
    The Historic PES Legend

  24. I am also interested in using it to bring up a couple of asymmetrical muscles. Read about a guy having good success on his bicep.

    This stuff is getting hard to find though...

  25. Quote Originally Posted by kingdong View Post
    Fair enough. I wonder what it is that makes the fat cells in the neck store the left over fat. Some people can eat extra callories and not store extra fat at all, so I wonder I wonder if these supplement would have similar side effects to the AIDS drugs(obviously less pronounced)


    I guess this is one of those situatons where we should be getting Dr. D or some other really smart person to come in and teach us a lesson in biology.
    I honestly don't know why it stores in the neck. It looks freaky though, google image search on that string and you'll see what i mean.

  26. For relatively lean individuals, I would agree. But for those who "need" to lose fat, I think the numerous deletrerious health risks of having excess bodyfat outweight the positives of holding onto it.



    Quote Originally Posted by Robboe View Post
    I don't think fat cell apoptosis is a very great idea in the grand scheme of things. Fat cells are important stores to the body.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7

  27. Quote Originally Posted by Whacked View Post
    For relatively lean individuals, I would agree. But for those who "need" to lose fat, I think the numerous deletrerious health risks of having excess bodyfat outweight the positives of holding onto it.
    Yes. Alternative drugs are suggested for peoiple in this situation though. Along with 'a balanced diet and exercise'.

  28. Quote Originally Posted by MAxximal View Post
    Hey Guys

    I read some studies about "killing fat cells" what did you think?

    Resveratrol and Quercetin
    Enhanced inhibition of adipogenesis and induction ... [Life Sci. 2008] - PubMed result

    Quercetin and Caffeine
    Potentiation of beta-adrenoceptor agonist-mediated... [Biochem Pharmacol. 1994] - PubMed result

    CLA and l-Arginine
    Dietary Supplementation of l-Arginine and Conjugated Linoleic Acid Reduces Retroperitoneal Fat Mass and Increases Lean Body Mass in Rats ? J. Nutr.

    CLA has been shown to cause apoptosis in rats but in human??
    studies have also shown that CLA blocks the ‘fat sensor’ PPAR-gamma.

    Curcumin also inhibits the production of PPAR-gamma, the sensor that alerts fat cells to the presence of fat. If the sensor works less well, fat cells absorb less fat.

    Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice ? J. Nutr.

    Capsaicin inhibit fat cell growth?
    Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications ? Am J Clin Nutr

    Dihydrocapsiate is similar to capsaicin, which is known for its thermogenic properties
    Effect of dihydrocapsiate on resting metabolic rate in humans ? Am J Clin Nutr
    This is why I added Quercetin, NAC, and Res-v into Free Test- on of the main things people notice when they take it is not only an increase in lbm, but also a decrease in body fat......
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals

  29. Quote Originally Posted by rms80 View Post
    This is why I added Quercetin, NAC, and Res-v into Free Test- on of the main things people notice when they take it is not only an increase in lbm, but also a decrease in body fat......
    we need an 120 caps version or 180 caps to bump to 6 caps a day



    note: did you read my PM?

  30. i added yohimbine to the bottle of capsacian sold as arthritis relief. the 1st thing i noticed is the burn, then when i exercised i noticed increased sweat where i applied it. my abs are my weak spot so it took some time, but i definately could tell a difference. it is relatively cheap so i use it a couple of times a week. definately worth a shot.


    btw-the capsacian works considerably better than the absorbine jr that i had added yohimbine to previously.

  31. Quote Originally Posted by MAxximal View Post
    we need an 120 caps version or 180 caps to bump to 6 caps a day



    note: did you read my PM?

    5 caps of Free Test contains an effective dose of all three compounds- by effective dose- we tend to use the doses used in scientific literature, where applicable....

    Quercetin is a great compound, but a huge pain in the ass to work with- that's why you don't see it in more products. It has a waxy texture that tends to jam automatic capsule machines, plus it is a strong die that tends to coat and stain just about everything (even the FRP inside our clean room, LOL). The only thing that removes it is Krud Kutter- alcohol and bleach are no match for it- it will stain SS

    Tell you a funny story- we have a pneumatic ejection pin system on our automatic capsule machine, and the the system ejects capsules out into an enclosed bin. The bin has a special suction that clears associated dust that goes along with each ejection- unfortunately, it quit working one day when we were making Free Test- so basically the dust from an entire 300K capsule run got deposited all over the encapsulation area. Problem is, you don't really see it until it starts to accumulate- I have never seen a mess like that in my entire life- took us 2 days to clean up after that run.....

    Can you re-send the PM
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals

  32. Quote Originally Posted by rms80 View Post
    5 caps of Free Test contains an effective dose of all three compounds- by effective dose- we tend to use the doses used in scientific literature, where applicable....

    Quercetin is a great compound, but a huge pain in the ass to work with- that's why you don't see it in more products. It has a waxy texture that tends to jam automatic capsule machines, plus it is a strong die that tends to coat and stain just about everything (even the FRP inside our clean room, LOL). The only thing that removes it is Krud Kutter- alcohol and bleach are no match for it- it will stain SS

    Tell you a funny story- we have a pneumatic ejection pin system on our automatic capsule machine, and the the system ejects capsules out into an enclosed bin. The bin has a special suction that clears associated dust that goes along with each ejection- unfortunately, it quit working one day when we were making Free Test- so basically the dust from an entire 300K capsule run got deposited all over the encapsulation area. Problem is, you don't really see it until it starts to accumulate- I have never seen a mess like that in my entire life- took us 2 days to clean up after that run.....

    Can you re-send the PM
    I say this with love:
    The Historic PES Legend

  33. LOL- it looked liked someone dropped a pollen bomb in there- went right through everyones' lab coats...
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals

  34. Quote Originally Posted by nattydisaster View Post
    Hmmmm very interesting. I knew the goal has always been to shrink fat cells, but now it seems people are looking to just kill them!

    I think there is a phosphotidylcholine + Bile Salt product being researched right now for this by big pharma
    What is a word that starts with d and ends in iarrhea? lol
    Gain Strength. Add Lean Mass. Recover Faster. : ERGONINE

  35. Quote Originally Posted by BrockR View Post
    I've been looking into PGF2a for transdermal use
    I've looked into that as well pgcl in a transdermal form. Never decided to do it though. Its easy to get and very cheap but I have also been debating between small very shallow frequent injections of lipodissolve.

    I have now decided though, I am just getting ab/torso lipo when I get my gyno surgery in less than a year hopefully.

  36. Quote Originally Posted by rms80 View Post
    This is why I added Quercetin, NAC, and Res-v into Free Test- on of the main things people notice when they take it is not only an increase in lbm, but also a decrease in body fat......
    I use Quercetin to rid my gout and it works just as well as the meds im perscribed. I started to use NAC regularly last year and found out its best to add extremely high doses of Vit. C, other wise NAC will interfere with insulin sensitivity or something like that. As for Resveratrol I wish I could take Sustain Alpha year round...Perhaps Primordial Performance will release a Liquavade Trans-Resvertrol solo.
    Primordial Performance
    ( at heart )

  37. Quote Originally Posted by rulk22 View Post
    I use Quercetin to rid my gout and it works just as well as the meds im perscribed. I started to use NAC regularly last year and found out its best to add extremely high doses of Vit. C, other wise NAC will interfere with insulin sensitivity or something like that. As for Resveratrol I wish I could take Sustain Alpha year round...Perhaps Primordial Performance will release a Liquavade Trans-Resvertrol solo.

    Liquavade Trans-Resvertrol solo.

    WHEN IS OUT???

  38. Quote Originally Posted by Whacked View Post
    For relatively lean individuals, I would agree. But for those who "need" to lose fat, I think the numerous deletrerious health risks of having excess bodyfat outweight the positives of holding onto it.
    It's important to note though that as these theoretical (or real) products would be killing fat cells, not just decreasing their volume, they should still be targetted for morbidly obese folks. It takes a lot to actually cause adipose hyperplasia, and a long time to develop it, too, so even if you were still say at 25% bf and looking to drop, if you have only had that for a few years I would be very wary of using such products since you don't have a lot of adipose cells (just really inflated ones).
  

  
 

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