kill Fat Cells
- 02-25-2011, 10:47 AM
- 02-25-2011, 12:05 PM
- 02-25-2011, 03:39 PM
As far as NAC- the effects seem to be negligible on insulin sensitivity:
J Physiol. 2010 May 1;588(Pt 9):1623-34. Epub 2010 Mar 22.
N-Acetylcysteine does not affect glucose disposal during prolonged moderate-intensity exercise in humans.
Merry TL, Wadley GD, Stathis CG, Garnham AP, Rattigan S, Hargreaves M, McConell GK.
Department of Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia. email@example.com
There is evidence that reactive oxygen species (ROS) signalling is required for normal increases in glucose uptake during contraction of isolated mouse skeletal muscle, and that AMP-activated protein kinase (AMPK) is involved. The aim of this study was to determine whether ROS signalling is involved in the regulation of glucose disposal and AMPK activation during moderate-intensity exercise in humans. Nine healthy males completed 80 min of cycle ergometry at 62 +/- 1% of peak oxygen consumption ( V(O(2)peak).A 6,6-(2)H-glucose tracer was infused at rest and during exercise, and in a double-blind randomised cross-over design, N-acetylcysteine (NAC) or saline (CON) was co-infused. NAC was infused at 125 mg kg(1) h(1) for 15 min and then at 25 mg kg(1) h(1) for 20 min before and throughout exercise. NAC infusion elevated plasma NAC and cysteine, and muscle NAC and cysteine concentrations during exercise. Although neither NAC infusion nor exercise significantly affected muscle reduced or oxidised (GSH or GSSG) concentration (P > 0.05), S-glutathionylation (an indicator of oxidative stress) of a protein band of approximately 270 kDa was increased approximately 3-fold with contraction and this increase was prevented by NAC infusion. Despite this, exercised-induced increases in tracer determined glucose disposal, plasma lactate, plasma non-esterified fatty acids (NEFAs), and decreases in plasma insulin were not affected by NAC infusion. In addition, skeletal muscle AMPKalpha and acetyl-CoA carboxylase-beta (ACCbeta) phosphorylation increased during exercise by approximately 3- and approximately 6-fold (P < 0.05), respectively, and this was not affected by NAC infusion. Unlike findings in mouse muscle ex vivo, NAC does not attenuate skeletal muscle glucose disposal or AMPK activation during moderate-intensity exercise in humans.
J Endocrinol Invest. 2009 Apr;32(4):352-6.
N-acetylcysteine is able to reduce the oxidation status and the endothelial activation after a high-glucose content meal in patients with Type 2 diabetes mellitus.
Masha A, Brocato L, Dinatale S, Mascia C, Biasi F, Martina V.
Department of Internal Medicine, Division of Endocrinology, University of Turin, Corso A.M. Dogliotti 14, 10126 Turin, Italy.
Post-prandial hyperglycemia seems to play a pivotal role in the pathogenesis of the cardiovascular complications of diabetes mellitus, as it leads to an oxidative stress which in turn causes a reduced NO bioavailability. These conditions produce an endothelial activation.
AIM OF THE STUDY: The aim of this study was to assure that the administration of N-acetylcysteine (NAC), thiolic antioxidant, is able to decrease the oxidation status and endothelial activation after a high-glucose content meal.
SUBJECTS AND METHODS: Ten patients with Type 2 diabetes mellitus (DMT2) (Group 1) and 10 normal subjects (Group 2) were studied. They assumed a high-glucose content meal without (phase A) or after (phase B) the administration of NAC. Glycemia, insulinemia, intercellular adhesion molecule 1, vascular adhesion molecule 1 (VCAM-1), E-selectin, malonaldehyde (MDA), and 4-hydroxynonenal (HNE) were assessed at -30, 0, +30, +60, +90, +120, and +180 min with respect to the meal consumption.
RESULTS: During the phase A in Group 1, only HNE and MDA levels increased after the meal assumption; all parameters remained unchanged in Group 2. During the phase B, in Group 1, HNE, MDA, VCAM-1, and E-selectin levels after the meal were lower than those in phase A, while no change for all variables were observed in Group 2.
CONCLUSIONS: A high-glucose meal produces an increase in oxidation parameters in patients with DMT2. The administration of NAC reduces the oxidative stress and, by doing so, reduces the endothelial activation. In conclusion, NAC could be efficacious in the slackening of the progression of vascular damage in DMT2.Dirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals
02-27-2011, 03:21 AM
02-27-2011, 04:41 PM
02-27-2011, 10:02 PM
Yeah I can vouch for that, we never monitor blood glucose during APAP overdoses when giving mucomyst (NAC) and believe me some amazingly high doses are given.
Gain Strength. Add Lean Mass. Recover Faster. : ERGONINE
02-27-2011, 10:19 PM
"PPAR-gamma" and CLA?
isnt the PPAR-gamma involved or influenced by TTA too?
The difference between who you are and who you want to be is what you do.
02-28-2011, 07:46 AM
02-28-2011, 09:49 AM
02-28-2011, 09:57 AM
02-28-2011, 10:03 AM
02-28-2011, 10:13 AM
The Historic PES Legend
02-28-2011, 06:14 PM
Fish oil also (specifically EPA DHA) are great for fat loss too and leucine don't forget.
Ageforce rep, Lets patch up those mistakes and stop going oral.
Knowledge is power- The power to do your part and make a difference.
04-07-2011, 10:19 AM
Decreased fat storage by Lactobacillus paracasei
a little update guys
07-31-2011, 08:19 PM
07-31-2011, 11:48 PM
i use some of these off and am using CLA now only 4g ed though. also Resveratrol off and on
LG Sciences Board Rep
These statements have not been evaluated by the FDA, do not constitute medical advice, and are not official or authorized comments by LG Sciences, LLC.
08-01-2011, 12:49 PM
A Norwegian study says that CLA may increase thrombocytes, which is potentially dangerous for people with a history of pulmonary embolism.
10-02-2011, 06:17 PM
Apoptosis appears to be a routine event....
Well isn't possible to get rid of fat cells only shink them.... Wrong. Apoptosis appears to be a routine event.
10-02-2011, 06:30 PM
10-02-2011, 06:41 PM
10-02-2011, 07:33 PM
10-02-2011, 07:47 PM
10-02-2011, 07:49 PM
Similar Forum Threads
- By Eric Potratz in forum Weight LossReplies: 122Last Post: 06-01-2010, 08:22 AM
- By Eric Potratz in forum SupplementsReplies: 53Last Post: 12-31-2009, 01:09 PM
- By VolatileMX in forum News and ArticlesReplies: 31Last Post: 10-09-2006, 10:20 AM
- By VolatileMX in forum SupplementsReplies: 12Last Post: 09-27-2006, 09:25 PM
- By okboy63 in forum News and ArticlesReplies: 1Last Post: 05-16-2006, 03:45 PM