7-keto

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    7-keto


    Patent application title: 7-KETO DHEA for Psychiatric Use
    Inventors: Sharon Sageman Richard P. Brown
    Agents: JOHN S. PRATT, ESQ;KILPATRICK STOCKTON, LLP
    Assignees:
    Origin: ATLANTA, GA US
    IPC8 Class: AA61K3156FI
    USPC Class: 514178
    Publication date: 06/24/2010
    Patent application number: 20100160274


    Read more: 7-KETO DHEA for Psychiatric Use - Patent application - the use of 3-acetyl-7-oxo-dehydroepiandrosterone in the preparation of a medicament to treat or ameliorate psychiatric

    7-KETO DHEA for Psychiatric Use - Patent application - the use of 3-acetyl-7-oxo-dehydroepiandrosterone in the preparation of a medicament to treat or ameliorate psychiatric

    Sixteen Case Reports

    [0113]In all the patient reports that follow, 7-keto DHEA was administered orally. The medications taken by the patients were continued unchanged during 7-keto DHEA administration. The patients generally reported the results to the clinician at the office visit following the administration of 7-keto DHEA.

    [0114]Patient 1 A 51 year old male with PTSD and Generalized Anxiety Disorder following a street mugging that caused head trauma and concussion. Patient had less anxiety within 2 days on 7-keto DHEA--25 mg/day.

    [0115]Patient 2 A 58 year old female with PTSD, chronic anxiety and Major depression had less anxiety and depression on 7-keto DHEA--50 mg/day.

    [0116]Patient 3 A 45 year old female with Panic Disorder and Generalized Anxiety Disorder had less anxiety and panic on 7-keto DHEA--25 mg/day.

    [0117]Patient 4 A 57 year old female with PTSD and Generalized Anxiety Disorder and Bipolar Depression was less anxious and depressed on 7-keto DHEA-25 mg/day.

    [0118]Patient 5 A 39 year old female with Bipolar Depression and PTSD was less anxious and depressed on 7-keto DHEA--25 mg/day.

    [0119]Patient 6 A 52 year old female with Tourette's Syndrome and chronic dysthymia, anxiety, was calmer and in a better mood on 7-keto DHEA--50 mg/day).

    [0120]Patient 7 A 41 year old female with Ankylosing Spondylitis, chronic pain, and depression was calmer and less depressed on 7-keto DHEA--25 mg/day.

    [0121]Patient 8 A 46 year old female with Dissociative Disorder, PTSD, Major Depression and Dependent Personality Disorder improved on 7-keto DHEA--25 mg/day, and reported less anxiety and dissociation.

    [0122]Patient 9 A 46 year old female with PTSD, Generalized Anxiety Disorder and Major Depression was less anxious and depressed on 7-keto DHEA--25 to 50 mg/day.

    [0123]Patient 10 A 63 year old female with Bipolar Depression and PTSD was less anxious and depressed on 7-keto DHEA--25 mg/day.

    [0124]Patient 11 A 59 year old female with Bipolar Depression and PTSD was less anxious on 7-keto DHEA--25 mg/day.

    [0125]Patient 12 A 59 year old female with Bipolar Depression and PTSD was less anxious on 7-keto DHEA--25 mg/day.

    [0126]Patient 13 A 62 year old female with PTSD and Major Depression was less depressed and anxious on 7-keto DHEA--50 mg/day.

    [0127]Patient 14 A 51 year old female with Adult Attention Deficit Hyperactivity Disorder, Bereavement, and PTSD was less irritable and anxious on 7-keto DHEA--25 mg/day.

    [0128]Patient 15 A 49 year old female with Generalized Anxiety Disorder had lower anxiety and better mood on 7-keto DHEA--25 mg/day.

    [0129]Patient 16 A 49 year old female with Generalized Anxiety Disorder and Fibromyalgia had lower anxiety and irritability on 7-keto DHEA--25 mg/day.

    Example 3

    7-keto DHEA for Healing Treatment-Resistant Posttraumatic Stress Disorder, Panic Disorder, Anxiety, Depression and Other Conditions in Male and Female Patients

    Eight Case Reports

    [0130]Patient 1 A 44 year old married female with lifelong depression, winter worsening, PMDD (premenstrual dysphoric disorder), and sexual PTSD was intolerant of Paxil, Zoloft, Prozac, Lexapro, venlafaxine, Wellbutrin and S-adenosylmethionine (SAMe), improved after administration of 7-keto DHEA 75 mg/day and remained well about 2 years after treatment.

    [0131]Patient 2 A 61 year old married female was anxious all her life, hypertensive, fragile, had 4 years of depression due to stress and received 12 years of psychoanalysis. She could not tolerate Zoloft, Celexa, Wellbutrin, Effexor, Cymbalta, Remeron, and SAMe. Rhodiola helped to an extent, however administration of 7-keto DHEA 50 mg/day was very effective and she remained well for 13/4 years.

    [0132]Patient 3 A 55 year old married female with lifelong generalized anxiety disorder (GAD), panic disorder, and fibromyalgia syndrome/chronic fatigue syndrome (CFS) for 15 years, failed or couldn't tolerate three SSRIs (selective serotonin reuptake inhibitors), two tricyclic antidepressants, valproate, and lamotrigine (LMT Lamictal). She was partially helped by Remeron and SAMe. Administration of 7-keto DHEA 50 mg/day provided improvement in her symptoms and she has remained well for about 1 year.

    [0133]Patient 4 A 57 year old female with severe dissociative identity disorder (DID) and fibromyalgia syndrome and Bipolar Disorder, failed every anticonvulsant drug, atypical antipsychotic, antidepressant, many electroconvulsive therapies, multiple emergency room visits and hospitalizations, and was considered a treatment failure. She was administered 7-keto DHEA (200 mg/day), and has been well for a year and is able to read and function.

    [0134]Patient 5 A 59 year old female, married therapist with PTSD and bipolar 2 disorder who failed many antidepressants, anticonvulsant drugs, and atypical antipsychotics, partially improved on lamotrigine (LMT Lamictal)/Zoloft. Administration of 7-keto DHEA 50 mg/day in the summer 100 mg/day in the winter was very effective and she has remained well for 2 years.

    [0135]Patient 6 A 64 year old female who was a divorced mother failed most antidepressants, atypical antipsychotics and electroconvulsive therapy, partially responded to venlafaxine (but did not like the side effects) and Abilify in the past. Administration of 7-keto DHEA had tremendous positive effects in 1 week and she has remained well for about 1 year. She partially relapsed following a stressful episode (breast cancer). The dosage of 7-keto DHEA was then increased from 100 mg/day to 300 mg/day with good results.

    [0136]Patient 7 A 58 year old married therapist with lifelong depression, sexual PTSD and fibromyalgia syndrome/chronic fatigue syndrome for about 10 years, failed or was intolerant of many antidepressants. She partially responded to Doxepin but was intolerant of the side effects. SAMe made the Doxepin work better but 7 keto-DHEA (200 mg/day) provided a significant benefit and the patient has remained well for 9 months.

    [0137]Patient 8 A 58 year old lawyer with cognitive impairment in thinking and memory occurring after cancer chemotherapy (chemobrain) and chronic fatigue syndrome/Fibromyalgia after treatment for breast cancer; failed to respond to several SSRIs and alternative treatments. Administration of 7-keto DHEA 50 mg/day provided significant improvement.

    Read more: 7-KETO DHEA for Psychiatric Use - Patent application - the use of 3-acetyl-7-oxo-dehydroepiandrosterone in the preparation of a medicament to treat or ameliorate psychiatric

    Nearing the end of my Erase cycle. And after reading its writeup may start another and stack it with 7-keto. Just found this abstract in a search and wanted to share. It is much longer than this but these results were interesting because I was diagnosed manic depressive/schiizoid years ago and am always looking for less side effect prone substances other than prescriptions to help out.
    "I don't want anything. I don't want anybody. That's the worst part. When the want goes, that's bad."
    (Doug Stanhope as Eddie on Louie)

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    Interesting read...

    I was under the impression that DHEA / 7-keto were basically useless when taken orally.

    Also noticed all but one of the patients were above 40.
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    Quote Originally Posted by BrockR View Post
    Interesting read...

    I was under the impression that DHEA / 7-keto were basically useless when taken orally.

    Also noticed all but one of the patients were above 40.
    7-keto DHEA yes but the 7-alpha and 7-beto no was already converted in 7-OH potent cortisol suppressor with great oral bioavailability

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    Quote Originally Posted by MAxximal View Post
    great suggestion
    "I don't want anything. I don't want anybody. That's the worst part. When the want goes, that's bad."
    (Doug Stanhope as Eddie on Louie)
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    Quote Originally Posted by BrockR View Post
    Interesting read...

    I was under the impression that DHEA / 7-keto were basically useless when taken orally.

    Also noticed all but one of the patients were above 40.
    That is the stickler.
    From many of the studies I have read the best results come from either when one is 35 and older.
    Unless a person is relatively obese and 300-600 of 7-Keto can be taken to help.
    And some propose 200-500 mg DHEA for mental enhancement as well.

    Had them saved but I installed a different OS and wiped my hard drive.
    If I find them again I'll post them.
    "I don't want anything. I don't want anybody. That's the worst part. When the want goes, that's bad."
    (Doug Stanhope as Eddie on Louie)
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    teh shiz
  

  
 

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