3,3 and 3,5 diido - AnabolicMinds.com

3,3 and 3,5 diido

  1. New Member
    mmacrazy's Avatar
    Stats
    5'10"  182 lbs.
    Join Date
    Aug 2010
    Age
    35
    Posts
    490
    Rep Power
    1148

    Reputation

    Question 3,3 and 3,5 diido


    Can someone explain what the difference is between these 2 ? Thanks

  2. Professional Member
    mich29's Avatar
    Join Date
    Aug 2010
    Posts
    4,519
    Rep Power
    107132

    Reputation Reputation Reputation

    Exclamation


    Quote Originally Posted by mmacrazy View Post
    Can someone explain what the difference is between these 2 ? Thanks
    3,3 is a metabolite of t3.

    3,5i is a metabolite of t4.

    check out pubmed there are some interesting studies on these.
  3. ax1
    Elite Member
    ax1's Avatar
    Stats
    4'6"  170 lbs.
    Join Date
    Jun 2008
    Posts
    5,383
    Rep Power
    1092781

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    below is a qoute, not sure who it came from

    3,3'-Diiodothyronine
    Advantages
    * Almost no suppression of TSH/hypothalamic-pituitary-thyroid axis
    * Stimulates cytochrome c oxidase - aka decouples Electron Transport Chain (slightly more than 3,5-T2)
    * Precursor to T3 & T4 (which have their own metabolic properties of course)

    Disadvantages
    * Interferes with plasma membrane transport of T3
    * No significant increases in growth hormone seen at any dosing levels

    3,5-Diiodothyronine
    Advantages
    * Increases serum levels of growth hormone (GH) comprable to T3
    * Stimulates cytochrome c oxidase - aka decouples Electron Transport Chain (slightly less than 3,3'-T2)
    * Does not interfere with plasma membrane transport of T3
    * Increases activation of Glucose-6-Phosphate Dehydrogenase

    Disadvantages
    * Suppression of TSH/hypothalamic-pituitary-thyroid axis is only slightly less but comprable to that of T3


    Summary
    If one is looking for strictly an increase in energy expenditure with less TSH depression, 3,3'-T2 is your answer..... If one is looking for more muscle mass preservation properties aswell and doesn't mind some TSH depression, 3,5-T2 is your answer....

    On a final note though, I think T3 supplementation would probably be better than 3,5-T2 supplementation as serum 3,5-T2 as well as 3,3'-T2 concentrations have been shown to rise significantly with a marked rise in serum T3 following T3 administration. Also, just because T3 acts on the protein synthesis mechanism involved in the regulation of the mitochondrial mass (so is more indirect pathway) while both T2 act directly at the mitochondrial level, this doesn't mean it is less effective at interupting the ETC, in fact, T3 has been shown to exhibit slightly more of an effect even though it acts indirectly on the mitochondria....
    나는 2000년 10월 매들린 올브라이트 전 미 국무장관 매들린 사랑, 그 중 한 뜨거운 젠장!
    •   
       

  4. New Member
    mmacrazy's Avatar
    Stats
    5'10"  182 lbs.
    Join Date
    Aug 2010
    Age
    35
    Posts
    490
    Rep Power
    1148

    Reputation

    Ok I looked at pubmed but not being a med student I found it kind of hard to understand.

    The reason I ask is because Alpha T2 has 3,3 ; anarchy covalex as a pwo has 3,5 and apparently based off some responses in another thread that is a very bad thing.

    Why is 3,3 ok and 3,5 is not? Is one better than another? Do they work across different pathways to achieve the same goal ?
  5. Board Moderator
    Never enough
    EasyEJL's Avatar
    Stats
    5'10"  205 lbs.
    Join Date
    Jun 2007
    Age
    46
    Posts
    31,830
    Rep Power
    768795

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    the 3,3 is nonsuppressive mostly. Really a combo of the 2 is best overall, taken at around 200-300mcg of each a day.
    This space for rent

    Phenadrol Log http://anabolicminds.com/forum/suppl...-hell-did.html - AMAZING fat loss results so far
  6. New Member
    micro2000's Avatar
    Join Date
    Mar 2005
    Age
    42
    Posts
    51
    Rep Power
    143

    Reputation

    Quote Originally Posted by mich29 View Post
    3,3 is a metabolite of t3.

    3,5i is a metabolite of t4.

    check out pubmed there are some interesting studies on these.
    T3 is a metabolite of T4. 3,3-T2 is speculated to be a metabolite of reverse-T3 (the inactive metabolite of T3), while 3,5-T2 is a metabolite T3.

    The research on 3,3-T2 doesn't support any claims for increase in metabolic rate, whereas 3,5-T2 does.
  7. Senior Member
    SamBoz19's Avatar
    Stats
    6'4"  285 lbs.
    Join Date
    Sep 2007
    Age
    30
    Posts
    2,691
    Rep Power
    35299

    Reputation

    Quote Originally Posted by mmacrazy View Post
    Ok I looked at pubmed but not being a med student I found it kind of hard to understand.

    The reason I ask is because Alpha T2 has 3,3 ; anarchy covalex as a pwo has 3,5 and apparently based off some responses in another thread that is a very bad thing.

    Why is 3,3 ok and 3,5 is not? Is one better than another? Do they work across different pathways to achieve the same goal ?
    The simple answer is that 3,3 isn't suppressive and won't destroy your energy levels and make you feel like a lethargic piece of sh*t. 3,5 on the other hand will make you feel lethargic and cause suppression of your natural thyroid production. If you go with a 3,5 product make sure to use some l-tyrosine as thyroid pct of sorts after your done with your cycle of it

    Cheers!

    -Sean-

    Primordial Performance
    "Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
  8. New Member
    fanzdslpwr's Avatar
    Stats
    5'6"  215 lbs.
    Join Date
    Jun 2009
    Posts
    341
    Rep Power
    244

    Reputation

    how much tyrosine is recommended to pct your thyroid?
  9. Professional Member
    southpaw23's Avatar
    Stats
    5'11"  165 lbs.
    Join Date
    Jun 2010
    Posts
    3,376
    Rep Power
    1387264

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    Quote Originally Posted by mmacrazy View Post
    Ok I looked at pubmed but not being a med student I found it kind of hard to understand.

    The reason I ask is because Alpha T2 has 3,3 ; anarchy covalex as a pwo has 3,5 and apparently based off some responses in another thread that is a very bad thing.

    Why is 3,3 ok and 3,5 is not? Is one better than another? Do they work across different pathways to achieve the same goal ?
    Tried the Anarchy Covalex and it made me feel lethargic. I've heard others report the same thing. It shares many of the same ingredients as their fat-burner Clenbutrx (which is a great product), except Anarchy has minimal amounts of both creatine and BA, not sure what the benefit was from adding 3,3 and 3,5 to the formula. I would go with Maximize V2, per scoop it's much stronger and to my knowledge dosed correctly. You'll get quality results from that product and it's one of the strongest PWO's out there, in terms of stim content.
  10. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122080

    Reputation Reputation Reputation

    Quote Originally Posted by fanzdslpwr View Post
    how much tyrosine is recommended to pct your thyroid?
    for 3,5 Diiodo L Thyronine you NOT NEED PCT you can go up to 800mcg safetly and after cesation your body will regulate your thyroids but if you go with doses above 4000mcg you got problems


    the problem consists in levels of thyroid-stimulating hormone goes low the same rule when you use PH`s your body low or stop the hormone production then you need restart them.
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  11. New Member
    mmacrazy's Avatar
    Stats
    5'10"  182 lbs.
    Join Date
    Aug 2010
    Age
    35
    Posts
    490
    Rep Power
    1148

    Reputation

    Cool. Thanks for all the quality replies.

    Was thinking of trying 1 scoop anarchy with a scoop of asgt today. See what kinda workout that'll give me.

    Maximize is def next on my list !
  12. Elite Member
    criticalbench's Avatar
    Stats
    5'1"  0 lbs.
    Join Date
    Apr 2010
    Posts
    7,829
    Rep Power
    767474

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    Quote Originally Posted by mich29 View Post
    3,3 is a metabolite of t3.

    3,5i is a metabolite of t4.

    check out pubmed there are some interesting studies on these.
    All you need to know.

    Mike
  13. Professional Member
    mich29's Avatar
    Join Date
    Aug 2010
    Posts
    4,519
    Rep Power
    107132

    Reputation Reputation Reputation

    Quote Originally Posted by criticalbench View Post
    All you need to know.

    Mike
    yea i tend to check out studies and then user reviews and then do even more research before even thinking about using a supplement.
  14. New Member
    narraboth's Avatar
    Join Date
    Mar 2010
    Posts
    263
    Rep Power
    187

    Reputation

    sorry, i misread them as 3.3 and 3.5 dildo LOL
  15. Elite Member
    criticalbench's Avatar
    Stats
    5'1"  0 lbs.
    Join Date
    Apr 2010
    Posts
    7,829
    Rep Power
    767474

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    Quote Originally Posted by narraboth View Post
    sorry, i misread them as 3.3 and 3.5 dildo LOL
    That would be one hell of a special dildo! haha
  

  
 

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in