Forskolin up-regulates aromatase

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    That is also mentioned in the PP article. Really good to know.
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    Didnt read the study, but that's probably what made me emotional and bloated on it.
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    Quote Originally Posted by pool_shark View Post
    That is also mentioned in the PP article. Really good to know.
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    I know it's an old thread but bump for cooper for thoughts
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    Subbed.

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    Also subbed
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    Quote Originally Posted by Bryancap77 View Post
    Also subbed
    Monday bump for now.
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    Does this mean that it can be used as na AI?
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    Ok now I need a smart person to read the study and give it to me in laymen terms
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    Quote Originally Posted by amarula View Post
    Does this mean that it can be used as na AI?
    No the study is claiming an increase in aromatase that would mean more estrogen. Although I have not read the study yet.
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    Cooper has some things going on at the moment. He will be back next week
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    Quote Originally Posted by nattydisaster View Post
    Cooper has some things going on at the moment. He will be back next week
    lol Love this site here we have jim & other looking like for weekName:  Unsure-Larry-David.gif
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    It appears that anything that increases cAMP increases aromatase activity.
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    Relevance to non-oncogenic cell lines? Nil. cAMP is a known second messenger in growth and potentiation of oncogenic cascades. It's similar to the study showing that arachidonic acid would make cancer worse...yes, it would, because certain cancers are associated with high ArA levels.

    Further, a trial in women noted no change in estrogen levels
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    Quote Originally Posted by mr.cooper69 View Post
    Relevance to non-oncogenic cell lines? Nil. cAMP is a known second messenger in growth and potentiation of oncogenic cascades. It's similar to the study showing that arachidonic acid would make cancer worse...yes, it would, because certain cancers are associated with high ArA levels.

    Further, a trial in women noted no change in estrogen levels
    Wow next week came fast lol


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    I'm just a little (ok, maybe a lot) ill
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    The above is my own opinion and does not reflect the opinion of PES
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    Quote Originally Posted by mr.cooper69 View Post
    I'm just a little (ok, maybe a lot) ill
    Get better broski get rest!!! If ya need something hit me up
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    Quote Originally Posted by mr.cooper69 View Post
    I'm just a little (ok, maybe a lot) ill
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    Using transformed cell lines as a predictor as to what happens in normal can be dangerous. It also wasn't the purpose of their study. They were just trying to see if this cell line was viable or not. Forskolin was just used to figure out a potential mechanism. Whether ingestion of forskolin would achieve these concentrations in vivo and whether it would result in increased estradiol levels in normal tissues isn't known.

    What is known that a study in healthy males (not cell lines) showed an increase in testosterone.
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    Quote Originally Posted by USPlabsRep View Post
    Using transformed cell lines as a predictor as to what happens in normal can be dangerous. It also wasn't the purpose of their study. They were just trying to see if this cell line was viable or not. Forskolin was just used to figure out a potential mechanism. Whether ingestion of forskolin would achieve these concentrations in vivo and whether it would result in increased estradiol levels in normal tissues isn't known.

    What is known that a study in healthy males (not cell lines) showed an increase in testosterone.
    Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.
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    Quote Originally Posted by xhrr View Post
    Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.
    I posted a link to a study done in healthy males in another thread (it came out last month).
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    Quote Originally Posted by xhrr View Post
    Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.
    The mechanism of T elevation is through the testes and various enzymes
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    Quote Originally Posted by mr.cooper69 View Post
    The mechanism of T elevation is through the testes and various enzymes
    Yeah I went retarded for a second.
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    Quote Originally Posted by xhrr View Post

    Yeah I went retarded for a second.
    Never go full retard
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    Quote Originally Posted by EBF Inc View Post
    Never go full retard
    LMAO when I read his post, that was first thing that popped in my head.
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    Quote Originally Posted by EBF Inc View Post
    Never go full retard
    Haha I was about to post that before I switched it to what you quoted.
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    Quote Originally Posted by mr.cooper69 View Post
    The mechanism of T elevation is through the testes and various enzymes
    I think he was going for the "higher levels of adipose tissue (% BMI) are correlated with a propensity for higher individual's rates of estrogen as opposed to healthy BF ranges..." Not necessarily speaking in terms of natural test production.

    I could be wrong though, he DID go full retard...
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    Quote Originally Posted by PalmFist View Post
    I think he was going for the "higher levels of adipose tissue (% BMI) are correlated with a propensity for higher individual's rates of estrogen as opposed to healthy BF ranges..." Not necessarily speaking in terms of natural test production.

    I could be wrong though, he DID go full retard...
    Haha yes that is what I was alluding to all the while completely disregarding the MOA of forskolin. Guise, forgive me.
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    Just take a AI with it
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    Quote Originally Posted by horizons View Post
    Just take a AI with it
    not necessary
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    Quote Originally Posted by xhrr View Post

    not necessary
    I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

    But the knot is there
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    At 100mg it aggravated my gyno
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    Quote Originally Posted by EBF Inc View Post
    I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

    But the knot is there
    Quote Originally Posted by BBB View Post
    At 100mg it aggravated my gyno
    Wow I didn't know people were experiencing E related side effects, I never had a problem even at 100 mg. Could explain the anabolic effects it has on bone.
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    A AI may not be "necessary" so to speak but if I was taking anything like DAA or forskolin it can be beneficial to stack
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    Quote Originally Posted by horizons View Post
    A AI may not be "necessary" so to speak but if I was taking anything like DAA or forskolin it can be beneficial to stack
    Alphamax uses 50mg 95% Forksolin but we pair it with 75mg Arimistane(among other things), so may be a good option especially if you stack with Forskolin-95 to get high forksolin doses.
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    Quote Originally Posted by Adizzle1 View Post

    Alphamax uses 50mg 95% Forksolin but we pair it with 75mg Arimistane(among other things), so may be a good option especially if you stack with Forskolin-95 to get high forksolin doses.
    What else is in it?
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    Quote Originally Posted by Adizzle1 View Post
    Alphamax uses 50mg 95% Forksolin but we pair it with 75mg Arimistane(among other things), so may be a good option especially if you stack with Forskolin-95 to get high forksolin doses.
    Good stuff.
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    Quote Originally Posted by EBF Inc View Post
    What else is in it?
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