Forskolin up-regulates aromatase

[MAxximal]

http://joe.endocrinology-journals.org/cgi/reprint/180/1/125.pdf

 

[pool_shark]

That is also mentioned in the PP article. Really good to know.

 

[kingdong]

Didnt read the study, but that's probably what made me emotional and bloated on it.

 

[MAxximal]

That is also mentioned in the PP article. Really good to know.

True Bud!

 

[RecompMan]

I know it's an old thread but bump for cooper for thoughts

 

[Grayson]

Subbed.

About to go on AT2 + F95.

 

[Bryancap77]

Also subbed

 

[RecompMan]

Also subbed

Monday bump for now.

 

[amarula]

Does this mean that it can be used as na AI?

 

[rphash49]

Ok now I need a smart person to read the study and give it to me in laymen terms

 

[xhrr]

Does this mean that it can be used as na AI?

No the study is claiming an increase in aromatase that would mean more estrogen. Although I have not read the study yet.

 

[jimbuick]

mr.cooper69

 

[nattydisaster]

Cooper has some things going on at the moment. He will be back next week

 

[Touey]

Cooper has some things going on at the moment. He will be back next week

lol Love this site here we have jim & other looking like for week

 

[BBB]

It appears that anything that increases cAMP increases aromatase activity.

 

[mr.cooper69]

Relevance to non-oncogenic cell lines? Nil. cAMP is a known second messenger in growth and potentiation of oncogenic cascades. It's similar to the study showing that arachidonic acid would make cancer worse...yes, it would, because certain cancers are associated with high ArA levels.

Further, a trial in women noted no change in estrogen levels

 

[RecompMan]

Relevance to non-oncogenic cell lines? Nil. cAMP is a known second messenger in growth and potentiation of oncogenic cascades. It's similar to the study showing that arachidonic acid would make cancer worse...yes, it would, because certain cancers are associated with high ArA levels.

Further, a trial in women noted no change in estrogen levels

Wow next week came fast lol


Thabks

 

[mr.cooper69]

I'm just a little (ok, maybe a lot) ill

 

[RecompMan]

I'm just a little (ok, maybe a lot) ill

Get better broski get rest!!! If ya need something hit me up

 

[xhrr]

I'm just a little (ok, maybe a lot) ill

Did you get a flu shot? Never again will I get flu shots I get sick when I get them and stay healthy when I don't. #Conspiracy

 

[USPlabsRep]

Using transformed cell lines as a predictor as to what happens in normal can be dangerous. It also wasn't the purpose of their study. They were just trying to see if this cell line was viable or not. Forskolin was just used to figure out a potential mechanism. Whether ingestion of forskolin would achieve these concentrations in vivo and whether it would result in increased estradiol levels in normal tissues isn't known.

What is known that a study in healthy males (not cell lines) showed an increase in testosterone.

 

[xhrr]

Using transformed cell lines as a predictor as to what happens in normal can be dangerous. It also wasn't the purpose of their study. They were just trying to see if this cell line was viable or not. Forskolin was just used to figure out a potential mechanism. Whether ingestion of forskolin would achieve these concentrations in vivo and whether it would result in increased estradiol levels in normal tissues isn't known.

What is known that a study in healthy males (not cell lines) showed an increase in testosterone.

Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.

 

[mr.cooper69]

Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.

I posted a link to a study done in healthy males in another thread (it came out last month).

 

[mr.cooper69]

Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.

The mechanism of T elevation is through the testes and various enzymes

 

[xhrr]

The mechanism of T elevation is through the testes and various enzymes

Yeah I went retarded for a second.

 

[RecompMan]

Yeah I went retarded for a second.

Never go full retard

 

[cubsfan815]

Never go full retard

LMAO when I read his post, that was first thing that popped in my head.

 

[xhrr]

Never go full retard

Haha I was about to post that before I switched it to what you quoted.

 

[PalmFist]

The mechanism of T elevation is through the testes and various enzymes

I think he was going for the "higher levels of adipose tissue (% BMI) are correlated with a propensity for higher individual's rates of estrogen as opposed to healthy BF ranges..." Not necessarily speaking in terms of natural test production.

I could be wrong though, he DID go full retard...

 

[xhrr]

I think he was going for the "higher levels of adipose tissue (% BMI) are correlated with a propensity for higher individual's rates of estrogen as opposed to healthy BF ranges..." Not necessarily speaking in terms of natural test production.

I could be wrong though, he DID go full retard...

Haha yes that is what I was alluding to all the while completely disregarding the MOA of forskolin. Guise, forgive me.

 

[horizons]

Just take a AI with it

 

[xhrr]

Just take a AI with it

not necessary

 

[RecompMan]

not necessary

I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

But the knot is there

 

[BBB]

At 100mg it aggravated my gyno

 

[xhrr]

I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

But the knot is there

At 100mg it aggravated my gyno

Wow I didn't know people were experiencing E related side effects, I never had a problem even at 100 mg. Could explain the anabolic effects it has on bone.

 

[horizons]

A AI may not be "necessary" so to speak but if I was taking anything like DAA or forskolin it can be beneficial to stack

 

[Adizzle1]

A AI may not be "necessary" so to speak but if I was taking anything like DAA or forskolin it can be beneficial to stack

Alphamax uses 50mg 95% Forksolin but we pair it with 75mg Arimistane(among other things), so may be a good option especially if you stack with Forskolin-95 to get high forksolin doses.

 

[RecompMan]

Alphamax uses 50mg 95% Forksolin but we pair it with 75mg Arimistane(among other things), so may be a good option especially if you stack with Forskolin-95 to get high forksolin doses.

What else is in it?

 

[abformulations]

Alphamax uses 50mg 95% Forksolin but we pair it with 75mg Arimistane(among other things), so may be a good option especially if you stack with Forskolin-95 to get high forksolin doses.

Good stuff.

 

[Adizzle1]

What else is in it?

 

[RecompMan]

I can get down w that lol

But then the amount of forskolin will be at like 200-250 lmao. Let me wait on this

 

[abformulations]

Let me log it during my pct. In Nov

 

[CJ_Xfit89]

I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

But the knot is there

I think I may stay at 50mg now lol

 

[mr.cooper69]

I think I may stay at 50mg now lol

It is completely unrelated to forskolin

 

[CJ_Xfit89]

It is completely unrelated to forskolin

Back up to 100mg then hahah.

 

[mr.cooper69]

Wow I didn't know people were experiencing E related side effects, I never had a problem even at 100 mg. Could explain the anabolic effects it has on bone.

Generally speaking, anything that elevates T will elevate E in fashion. Now, that is NOT the same as forskolin directly upregulating aromatase

 

[BBB]

Generally speaking, anything that elevates T will elevate E in fashion. Now, that is NOT the same as forskolin directly upregulating aromatase

Are you saying that it does not upregulate aromatase?

 

[nattydisaster]

I've been on 100mg/day Forskolin-95 for two months

Had my bi-annual bloodwork last Tuesday and my estrogen was 32 ng/dl. 6 months ago, my estrogen was 34 ng/dl (no forskolin used here)

Both blood tests I was not taking any anti-estrogens or test boosters

 

[mr.cooper69]

Are you saying that it does not upregulate aromatase?

Yes. Again, the study cited has absolutely zero relevance to non-transformed cell lines.