megadosing L-carnitine

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  1. megadosing L-carnitine


    Carnitine is one of those amino's that should do a lot, but it's L form has low bioavailability. Has anyone tried high dosed L-carnitine to see if it matches the effects of things like PLCAR and GPLC?


  2. There's good reading out there on intaking L-Carnitine with either insulin, or large carb doses to spike insulin. Insulin is key in getting the L-Carnitine inito the mitochondria where we want it; you should be able to find a full via google.
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  3. I'd be more interested in seeing someone mega-dose l-carnitine l-tartrate.
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  4. Quote Originally Posted by Royd The Noyd View Post
    I'd be more interested in seeing someone mega-dose l-carnitine l-tartrate.
    x2!!! i have been thinking of alcar/lclt/gplc all at 3 grams 2xday.

  5. Quote Originally Posted by thebigt View Post
    x2!!! i have been thinking of alcar/lclt/gplc all at 3 grams 2xday.
    Would be costly....but probably very effective in terms of recovery.
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  6. with the increased androgen receptor density, dont forget to run a test booster with it! when i ran LCLT with just some 6 bromo the effects were greatly amplified, that and some divanyl would rock with this stack!
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  7. Quote Originally Posted by Royd The Noyd View Post
    Would be costly....but probably very effective in terms of recovery.
    exactly. i ran alcar/plcar/lclt at 3g twice a day for a couple of months. it took like a week to two to kick in, but the recovery aspect was incredible once it kicked in. I always dosed it on an empty stomach with 5-10g of amino acids, or a small shake. got the idea from a blurb i read at beverly ints website re:quadracarn... taking a break now, prime/intrabolic is taking care of my recovery issues now, but have a lot of carnitine bulk powders so I will be running this again.

  8. Quote Originally Posted by tnubs View Post
    with the increased androgen receptor density, dont forget to run a test booster with it! when i ran LCLT with just some 6 bromo the effects were greatly amplified, that and some divanyl would rock with this stack!
    i added lclt to my 200mg weekly test cyp on advice of andrew, it definitely spiked my aggression and feeling of alpha male. felt the difference within a few days of 3gram dosing.

  9. I enjoyed mega-dosing carnitines......until I developed TMAU. This is more common than you might think. It isn't fun going to the gym or work with FOS.

  10. I love ALCAR, the effects just don't last very long. I've read that if your going to dose L-C high, you better dose plenty of antioxidants.

  11. Quote Originally Posted by thebigt View Post
    x2!!! i have been thinking of alcar/lclt/gplc all at 3 grams 2xday.
    I used this stack and damn it The Mental Focus is INSANE!!!

    L-Carnitine L-Tartrate
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  12. Quote Originally Posted by lonewolf0420 View Post
    I love ALCAR, the effects just don't last very long. I've read that if your going to dose L-C high, you better dose plenty of antioxidants.
    agreed!!!

  13. Quote Originally Posted by thebigt View Post
    i added lclt to my 200mg weekly test cyp on advice of andrew, it definitely spiked my aggression and feeling of alpha male. felt the difference within a few days of 3gram dosing.
    Does GPLC exert the same effects as LCLT regarding receptor up regulation? If so, I would simply stick with GPLC as it has an affinity to flex its efficaciousness muscle... within the muscles

    Being specific to muscle tissue, increasing endurance and blood flow/pumps, if GPLC could also impart the same androgen receptor modulation and amplification I can't see why anyone would begin an AAS cycle or train at all for that matter, without running GPLC concurrently.

  14. Quote Originally Posted by SonicSWOLE View Post
    I enjoyed mega-dosing carnitines......until I developed TMAU. This is more common than you might think. It isn't fun going to the gym or work with FOS.
    Can you elaborate please?

    Quote Originally Posted by lonewolf0420 View Post
    I love ALCAR, the effects just don't last very long. I've read that if your going to dose L-C high, you better dose plenty of antioxidants.
    I was under the impression that LC in all forms exhibited some intrinsic anti oxidant activity in and of itself? Why the increased demand and necessity for supplemental AO's?

  15. Quote Originally Posted by Outstanding View Post
    Does GPLC exert the same effects as LCLT regarding receptor up regulation? If so, I would simply stick with GPLC as it has an affinity to flex its efficaciousness muscle... within the muscles

    Being specific to muscle tissue, increasing endurance and blood flow/pumps, if GPLC could also impart the same androgen receptor modulation and amplification I can't see why anyone would begin an AAS cycle or train at all for that matter, without running GPLC concurrently.
    although all the carnitines are related, it appears that they all have different effects. lclt from what i have read is the only carnitine with effect on androgen receptor, but at the same time alcar is recommended for bent penis, lol.

  16. some guy on here said that after megadosing L-carninite his sweat smelled like a dead fish. just throwing it out there

  17. yeah^^^ thats what sonic was saying. (TMAU)
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  18. I think the LCLT androgen receptor up-regulation study is quite flawed. Well maybe not flawed but taken out of context. The studies on recovery are however quite good and seem consistent (although mostly done by Volek/UCONN).
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  19. Quote Originally Posted by Royd The Noyd View Post
    I think the LCLT androgen receptor up-regulation study is quite flawed. Well maybe not flawed but taken out of context. The studies on recovery are however quite good and seem consistent (although mostly done by Volek/UCONN).



    tell us more on why the study is flawed. i have been on trt since 8/28/09 and when i use lclt my test cyp has noticeable increased kick to it.

  20. I have run it at over 20 grams a day. Watch out for your intestines as it can have a wicked laxative effect.

    Since this, and creatine, were the only products I could smuggle into AIT (right after basic), I dosed the liquid form 5 times a day with EXCELLENT body recomp results and amazing endurance.

    I'm looking to make a blended Liquid carnitine(fumerate, PLCAR, ALCAR, Tartarate) product here very soon.
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  21. Quote Originally Posted by AntonG42O View Post
    some guy on here said that after megadosing L-carninite his sweat smelled like a dead fish. just throwing it out there
    This can definitely happen.

    I've dosed between 10-20g and my sweat smelled like old rotting fish in a dumpster. It's disgusting.

    But high doses proved to be very effective for me so besides the smell and potential for stomach discomfort I can't complain.

  22. Quote Originally Posted by dsade View Post
    I have run it at over 20 grams a day. Watch out for your intestines as it can have a wicked laxative effect.

    Since this, and creatine, were the only products I could smuggle into AIT (right after basic), I dosed the liquid form 5 times a day with EXCELLENT body recomp results and amazing endurance.

    I'm looking to make a blended Liquid carnitine(fumerate, PLCAR, ALCAR, Tartarate) product here very soon.
    is there a reason for not including glpc, or is it purely a cost issue.

  23. Quote Originally Posted by thebigt View Post
    is there a reason for not including glpc, or is it purely a cost issue.
    I prefer PLCAR for sure, which is expensive enough. GPLC would add significant cost with very little to no (IMO) benefit.

    I will also be adding Pantethine and DL-Panthenol as a coenzyme A precursors with high efficiency and some evidence on its own supporting body recomposition.
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  24. Quote Originally Posted by dsade View Post
    I prefer PLCAR for sure, which is expensive enough. GPLC would add significant cost with very little to no (IMO) benefit.

    I will also be adding Pantethine and DL-Panthenol as a coenzyme A precursors with high efficiency and some evidence on its own supporting body recomposition.
    got to give you credit for sticking with plcar, with gplc getting so much praise these days. i know you have been a fan of plcar for a long time.

  25. Quote Originally Posted by dsade View Post
    I prefer PLCAR for sure, which is expensive enough. GPLC would add significant cost with very little to no (IMO) benefit.

    I will also be adding Pantethine and DL-Panthenol as a coenzyme A precursors with high efficiency and some evidence on its own supporting body recomposition.
    I agree. I whant PLCAR, not GPLC. Your product sounds awsome. You should make an ALCAR free version to, because their is a small chunk of the population who do't enjoy the way they feel on it. I swear, it gives me a temper.

  26. Quote Originally Posted by Outstanding View Post
    I was under the impression that LC in all forms exhibited some intrinsic anti oxidant activity in and of itself? Why the increased demand and necessity for supplemental AO's?
    Someone might clarify better or more accurately but carnitine brings fuel to your mitochondria. When this fuel is burned by your body oxidized waste material (free radicals) are formed. When your mega dosing carn your basically uping the potential for more free radicals. Its been a while since if read up on this stuff so if i missed or messed up on some finer points someone will correct me. A great solution some is green tea caps,a form of CoQ10, and maybe a form of r-ala if you can swing it.

  27. Quote Originally Posted by Frequency View Post
    Someone might clarify better or more accurately but carnitine brings fuel to your mitochondria. When this fuel is burned by your body oxidized waste material (free radicals) are formed. When your mega dosing carn your basically uping the potential for more free radicals. Its been a while since if read up on this stuff so if i missed or messed up on some finer points someone will correct me. A great solution some is green tea caps,a form of CoQ10, and maybe a form of r-ala if you can swing it.
    I can't rep you again

    I've been experimenting with ALA, to boost my AO's.


    In case I've miss read, what's considered "mega-dosing"?

  28. Quote Originally Posted by lonewolf0420 View Post
    I can't rep you again

    I've been experimenting with ALA, to boost my AO's.


    In case I've miss read, what's considered "mega-dosing"?
    I dont recall seeing many supps going over 2 grams for a serving or daily dose so if i had to personally give it a number id probably say 6 grams or more daily. Dsade is more or less the supp king in this thread so i would like to see his opinion.
    I believe ALA also helps recycle certain AO's, like vitamin C, which just makes it all the better supp to take.

  29. Quote Originally Posted by dsade View Post
    I have run it at over 20 grams a day. Watch out for your intestines as it can have a wicked laxative effect.

    Since this, and creatine, were the only products I could smuggle into AIT (right after basic), I dosed the liquid form 5 times a day with EXCELLENT body recomp results and amazing endurance.

    I'm looking to make a blended Liquid carnitine(fumerate, PLCAR, ALCAR, Tartarate) product here very soon.

    Whoooot!!! i`m in and ready Matt

    Jeezzz this is GREAT NEWS
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  30. Quote Originally Posted by dsade View Post
    I have run it at over 20 grams a day. Watch out for your intestines as it can have a wicked laxative effect.

    Since this, and creatine, were the only products I could smuggle into AIT (right after basic), I dosed the liquid form 5 times a day with EXCELLENT body recomp results and amazing endurance.

    I'm looking to make a blended Liquid carnitine(fumerate, PLCAR, ALCAR, Tartarate) product here very soon.
    Quote Originally Posted by dsade View Post
    I prefer PLCAR for sure, which is expensive enough. GPLC would add significant cost with very little to no (IMO) benefit.

    I will also be adding Pantethine and DL-Panthenol as a coenzyme A precursors with high efficiency and some evidence on its own supporting body recomposition.
    Nice! Any idea to when this will be coming out?

  31. I ran out of my ALCAR yesterday, and still waiting for my NP order to get here.

    I'm going through ALCAR withdrawal

  32. Quote Originally Posted by Frequency View Post
    Someone might clarify better or more accurately but carnitine brings fuel to your mitochondria. When this fuel is burned by your body oxidized waste material (free radicals) are formed. When your mega dosing carn your basically uping the potential for more free radicals. Its been a while since if read up on this stuff so if i missed or messed up on some finer points someone will correct me. A great solution some is green tea caps,a form of CoQ10, and maybe a form of r-ala if you can swing it.
    Excellent, great response. Thank you. I am on Glycobol with contains a very high amount of na-r-ALA, and I always take a greens supplement which contains an ORAC blend, so I believe I will be alright. I appreciate your help and explanation.

  33. Ive used all lots of L-carnitine before. LCLT, Acetyl, L-carnitine. Ive used up to 8grams a day but never thought to use 20-wow. Im a huge fan of L-carnitine and all its versions. The benefits ive seen are many, you can see and feel its effects for sure. Currently im running GPLC 3.5 grams, along with Arginocarn( imo currently the best form) 3 grams and im seeing great results. I get mine from Primordial Performance btw.

  34. Does anyone know exactly how many mg are in a 1/4tsp of NP's bulk ALCAR? I'm guessing I consume about 2.8g with each serving I have. That's figuring about 700mg per 1/4tsp. I consume 2-3 servings a day.

    I can't believe how much I miss this stuff. I'm chomping at the bit, waiting for my order to arrive.

  35. Quote Originally Posted by lonewolf0420 View Post
    Does anyone know exactly how many mg are in a 1/4tsp of NP's bulk ALCAR? I'm guessing I consume about 2.8g with each serving I have. That's figuring about 700mg per 1/4tsp. I consume 2-3 servings a day.

    I can't believe how much I miss this stuff. I'm chomping at the bit, waiting for my order to arrive.
    The old white bottle was 750mg.

  36. Quote Originally Posted by kingdong View Post
    The old white bottle was 750mg.
    Thank you. I would assume the black container would be the same.


    So the tiny "cc" scooper in the container would measure out 750mg?

  37. Quote Originally Posted by kingdong View Post
    Carnitine is one of those amino's that should do a lot, but it's L form has low bioavailability. Has anyone tried high dosed L-carnitine to see if it matches the effects of things like PLCAR and GPLC?

    why would you even bother.
    0.5g-1g of Acetyl L-Carnitine (ALCAR) would give you probibbly as much as 30g of just l-carnitine in terms of making it to your blood/brain ect.

    id just grab bulk ALCAR powder if i was you

  38. Quote Originally Posted by RAHHH View Post
    why would you even bother.
    0.5g-1g of Acetyl L-Carnitine (ALCAR) would give you probibbly as much as 30g of just l-carnitine in terms of making it to your blood/brain ect.

    id just grab bulk ALCAR powder if i was you
    depends what you want it for exactly i suppose. Like i try to make clear i have very limited knowledge on most subjects i enter but ill share what i have... the acetylation of ALCAR is what gives carnitine its great ability to cross the blood brain barrier as opposed just mainly affecting mitochondria everywhere in the body. Depending on what is attached to carnitine, along with many other things, depicts what effect it will have. I believe propionyl-L-carnitine is the form that provides basic general carnitine benefits as the prpionyl(salt?ester?) helps with general absorption and plays some sort of role in the mitochondria.

  39. There is an excellent article pertaining to LCLT and many of the subjects mentioned in this thread in this month's MD ironically (with Roelly Winklaar on the cover)
  

  
 

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