Whenever you take it, it MUST BE ON AN EMPTY STOMACH. That means at least 2 hours after food, and wait an hour after dosing to eat. I hear some guys like it pre-workout, so eat 2.5 hours before, dose 1/2hr before, and avoid carbs for another hour. Sounds like hell to me, but good for a cut. It does work great for sleep, I took some Lipotopin PM the other night on a totally empty stomach and slept AWESOME. 6 hours felt like 8.