Casein Hydrosylates

[HawaiianPride]

Casein Hydrosylates Increase Protein Synthesis More Than Casein

Many people have been talking about whey protein hydrosylates, but now there are casein protein hydrosylates. Casein has a long-term effect in suppressing protein breakdown, which your body needs to sustain for 6 to 8 hours during sleep without food. In fact, a total release of Amino Acids in the bloodstream can last as long as 7 hours after ingestion of casein protein! Casein hydrosylate is a preparation made from the milk protein casein, which is hydrolyzed to break it down into its constituent Amino Acids.

The ingestion of a protein hydrosylate, as opposed to its intact proteins, has been proposed to facilitate protein digestion and absorption, increase plasma amino acid availability, and thereby increase muscle protein synthesis. A more rapid increase in circulating amino acid concentrations has previously been reported after the ingestion of whey protein hydrosylate, compared to regular whey protein.1 Whey protein hydrosylates have been shown to be superior to whey protein peptides for increasing protein synthesis, but what about casein hydrosylates?

Researchers from the Netherlands examined the effect of casein versus casein hydrosylates on protein synthesis. Subjects received a beverage containing 35 grams of casein or casein hydrosylates. Researchers measured insulin, protein synthesis and protein breakdown in two groups of men.

At the end of the study, researchers reported that ingestion of casein hydrosylate— as opposed to casein— increases the rate of plasma amino acid availability, and tends to increase muscle protein synthesis in humans.8

Researchers also observed a greater increase in plasma amino acid concentrations after ingestion of hydrolyzed casein, compared to its intact protein casein hydrosylates. This study supports an earlier study showing higher peak plasma amino acid concentrations after administration of hydrolyzed casein, compared to its intact protein (i.e., casein).2 The exogenous amino acid phenylalanine’s appearance rate increased to a greater extent after ingestion of the casein hydrosylate, compared to casein protein. During the 6-hour post-feeding period, 25 percent more dietary phenylalanine appeared in the circulation after ingestion of the hydrosylate, compared to the intact protein.

Consequently, this study shows that a hydrolyzed protein is more rapidly digested and absorbed, which results in a greater amino acid delivery. Thus, hydrolyzed casein provides a protein source that is more rapidly digested and absorbed in humans, which improves plasma amino acid availability.

Casein Hydrosylates Are Also More Anti-Catabolic

Another interesting finding was that protein breakdown rates tended to be further lowered after ingestion of protein hydrosylate, compared to casein protein, which may be due to the greater insulin release that was observed after protein hydrosylate ingestion.

Elevated insulin concentrations have been shown to inhibit protein breakdown.3,4,5 In contrast, it has been suggested that increases in circulating insulin concentrations are instrumental in stimulating skeletal muscle blood flow— thereby augmenting amino acid delivery to the muscle.6,7 Consequently, both the increase in plasma amino acid availability and the greater plasma insulin response after hydrolyzed casein— compared to casein ingestion (during the initial 3-hour post-feeding period)— might enhance postprandial muscle protein anabolism.

This result indicates that the intake of a casein hydrosylate, as opposed to casein, further stimulates the anabolic response to food intake mainly by inhibiting whole-body protein breakdown.

References:

1. Calbet JA, Holst JJ. Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrosylates in humans. Eur J Nutr, 2004;43:127-39.

2. Calbet JA, Holst JJ. Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrosylates in humans. Eur J Nutr, 2004;43:127-39.

3. Gelfand RA, Barrett EJ. Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J Clin Invest, 1987;80:1-6.

4. Biolo G, Williams BD, Fleming RY, Wolfe RR. Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise. Diabetes, 1999;48:949-57.

5. Fryburg DA, Jahn LA, Hill SA, Oliveras DM, Barrett EJ. Insulin and insulin-like growth factor-1 enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest, 1995;96:1722-9.

6. Fujita S, Rasmussen BB, Cadenas JG, Grady JJ, Volpi E. The effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab, 2006;291:E745-54.

7. Rasmussen BB, Fujita S, Wolfe RR, et al. Insulin resistance of muscle protein metabolism in aging. FASEB J, 2006;20:768-9.

8. Koopman R, Crombach N, Gijsen AP, Walrand S, Fauquant J, Kies AK, Lemosquet S, Saris WH, Boirie Y, van Loon LJ. Ingestion of a protein hydrosylate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. Am J Clin Nutr, 2009.

 

[JN230]

great write up bro!
casein hydrosolates can be very anabolic!

 

[rob211080]

It's expensive but it's one of the few supps that has real scientific research to back it up.

 

[davidl351]

there's another similar review done on casein hydrolysates by Lyle McDonald.

 

[SilentBob187]

In summation, PeptoPro for the win?

 

[davidl351]

does WPH yield a higher BCAA total?

 

[JN230]

Amino Acids – Including a good source of amino acids was a no brainer because they are the building blocks of muscle.

But we didn’t just add some cheap form of whey protein as an amino acid source. We included pure hydrolyzed casein known as PeptoPro® – in which the amino acids are bound together in peptide from.

The peptide form is the key to the superiority of PeptoPro, simply because peptides are the best absorbing form of amino acids known to man. (1) Just check out the graph below.

The di and tri-peptides from PeptroPro absorb up to 3x better than free form amino acids or longer chain proteins -



You see, amino acids can exist as single amino acids, long chain proteins or as short chain peptides of 2 or 3 amino acids. When amino acids exist in short peptide form, they are water soluble. In fact, mixing PeptoPro in water will result in a completely clear solution. On the other hand, if you mix whey or soy protein in water, you get a cloudy solution because these full protein chains are not 100% water soluble.

The water solubility of peptides allows them to pass through the aqueous barrier of the intestinal walls and penetrate the brush border in order to be absorbed into the blood stream.

As you can see, the full proteins must be broken down into smaller peptides before they can pass through the intestinal walls -



Now that we’ve established that PeptoPro is the fastest and most fully absorbing protein on the market, let me explain why taking PeptoPro before exercise is so important.

Taking PeptoPro before exercise causes a rapid increase in amino acid levels in the blood.(2) A recent study showed that maintaining high levels of amino acids during exercise (by consuming PeptoPro immediately 30-60 minutes beforehand) reverses muscular protein breakdown and starts to stimulate muscle protein synthesis during exercise. (4)

Yes, I said it. You can actually start building muscle during your workouts.

Plus, when amino acid levels are elevated during exercise, it actually initiates the muscle building process and increases the muscle building potential after exercise. (3)

In addition to maximizing muscle growth after exercise, supplementation with peptide based protein has been shown to promote recovery of muscle force better than regular whey or casein protein does –



PeptoPro is hands down, the best pre-exercise source of amino acids.

No soy.

No whey protein.

No free amino acids that have poor absorption and taste like bitter aspirin.

if you;d like to see the graphs that didnt post up correctly here ya go

its the easiest place for me to find info on casein hydrosolates, im feeling lazy today:thinking:

 

[HawaiianPride]

Great addition Jn..

 

[JN230]

do what i can broheim

 

[rugger48]

there's another similar review done on casein hydrolysates by Lyle McDonald.

did anybody catch this at all.

 

[HawaiianPride]

Sure did..

 

[davidl351]

Amino Acids – Including a good source of amino acids was a no brainer because they are the building blocks of muscle.

But we didn’t just add some cheap form of whey protein as an amino acid source. We included pure hydrolyzed casein known as PeptoPro® – in which the amino acids are bound together in peptide from.

The peptide form is the key to the superiority of PeptoPro, simply because peptides are the best absorbing form of amino acids known to man. (1) Just check out the graph below.

The di and tri-peptides from PeptroPro absorb up to 3x better than free form amino acids or longer chain proteins -



You see, amino acids can exist as single amino acids, long chain proteins or as short chain peptides of 2 or 3 amino acids. When amino acids exist in short peptide form, they are water soluble. In fact, mixing PeptoPro in water will result in a completely clear solution. On the other hand, if you mix whey or soy protein in water, you get a cloudy solution because these full protein chains are not 100% water soluble.

The water solubility of peptides allows them to pass through the aqueous barrier of the intestinal walls and penetrate the brush border in order to be absorbed into the blood stream.

As you can see, the full proteins must be broken down into smaller peptides before they can pass through the intestinal walls -



Now that we’ve established that PeptoPro is the fastest and most fully absorbing protein on the market, let me explain why taking PeptoPro before exercise is so important.

Taking PeptoPro before exercise causes a rapid increase in amino acid levels in the blood.(2) A recent study showed that maintaining high levels of amino acids during exercise (by consuming PeptoPro immediately 30-60 minutes beforehand) reverses muscular protein breakdown and starts to stimulate muscle protein synthesis during exercise. (4)

Yes, I said it. You can actually start building muscle during your workouts.

Plus, when amino acid levels are elevated during exercise, it actually initiates the muscle building process and increases the muscle building potential after exercise. (3)

In addition to maximizing muscle growth after exercise, supplementation with peptide based protein has been shown to promote recovery of muscle force better than regular whey or casein protein does –



PeptoPro is hands down, the best pre-exercise source of amino acids.

No soy.

No whey protein.

No free amino acids that have poor absorption and taste like bitter aspirin.

if you;d like to see the graphs that didnt post up correctly

its the easiest place for me to find info on casein hydrosolates, im feeling lazy today:thinking:

what do you think about whey protein that has been hydrolyzed to the same degree as casein? an example would be AEN's IntrAbolic. their label claims to have a MINIMUM di- & tri-peptide absorption rate of 65% and a maximum absorption rate similar to that of PeptoPro.

 

[athletor]

where buy Casein Hydrosylates?

 

[JN230]

pure or in a mix, if you're looking to use them around workout times they are in Pre-Max from primmordial performance, NO-Shotgun(thye dont list the amount) or im sure trueprotein.com has some