HGHup vs GHenerate
- 12-08-2009, 05:46 PM
- 12-08-2009, 05:57 PM
- 12-08-2009, 07:03 PM
I think that they both have their place. They work in different manners so sounds like a perfect stack to me!
12-09-2009, 09:41 AM
12-10-2009, 06:40 PM
My only preocupation about HGHup is about L-Dopa! I dont feel confortable to pick some dopamine precursor! Imagine it acts like any hormone (because it is a "neuro-hormone"!), shuting down your own production! In "nigra" substance You'd could developing Parkinson! And I think that much of these "euphoria" with HGHup could be the "euphoria" itsefl!!! Dopamine is one of plasure substances, like serotonin... I really don't know. I fearless something like GHRP and GHRH then "mix" with my brain.
And.... I don't have any commercial interting on , jusnt thoughts....
Aohh before someone ask: of course, english is not my fst language...
12-11-2009, 01:44 AM
I plan on running them both. I'm thinking of dosing 2,2,1 for the HGHUP, and doing 3-4 pumps of Ghenerate with each of those, and 1-2 caps of 1-GH-I. Pretty much would be dosing it about 1.5 hours after breakfast, about the same round 3 am or pm (depending on my work shift) and right before bed. Pretty sure I'll be needing some coffee while running it, but we'll see. Also going to be running lots of other stuff as well, but I know how that stuff works for me, so I should have a pretty good indicator of what that stack will do for me. I should call it the "Comatose stack".
12-11-2009, 07:32 AM
12-11-2009, 09:38 AM
12-11-2009, 09:52 AM
12-11-2009, 10:14 AM
12-11-2009, 12:52 PM
12-11-2009, 01:09 PM
Neuroprotective Effects of Huperzine A
A Natural Cholinesterase Inhibitor for the Treatment of Alzheimer's Disease
Rui Wang, Xi Can Tang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai, China
Huperzine A (HupA), isolated from Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase. It has been found to reverse or attenuate cognitive deficits in a broad range of animal models. Clinical trials in China have demonstrated that HupA significantly relieves memory deficits in aged subjects, patients with benign senescent forgetfulness, Alzheimer's disease (AD) and vascular dementia (VD), with minimal peripheral cholinergic side effects compared with other AChEIs in use. HupA possesses the ability to protect cells against hydrogen peroxide, -amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53 and caspase-3, protect mitochondria, and interfere with APP metabolism. Antagonizing effects on NMDA receptors and potassium currents may contribute to the neuroprotection as well. It is also possible that the non-catalytic function of AChE is involved in neuroprotective effects of HupA. The therapeutic effects of HupA on AD or VD are probably exerted via a multi-target mechanism.
Phytother Res. 2008 Jan;22(1):6-11.
Antiparkinson drug--Mucuna pruriens shows antioxidant and metal chelating activity.
Dhanasekaran M, Tharakan B, Manyam BV.
Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn, Alabama, USA.
Parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Oxidative stress plays an important role in the pathophysiology of Parkinson's disease. The ancient Indian medical system, Ayurveda, traditionally uses Mucuna pruriens to treat Parkinson's disease. In our earlier studies, Mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson's disease. The antioxidant activity of Mucuna pruriens was demonstrated by its ability to scavenge DPPH radicals, ABTS radicals and reactive oxygen species. Mucuna pruriens significantly inhibited the oxidation of lipids and deoxyribose sugar. Mucuna pruriens exhibited divalent iron chelating activity and did not show any genotoxic/mutagenic effect on the plasmid DNA. These results suggest that the neuroprotective and neurorestorative effect of Mucuna pruriens may be related to its antioxidant activity independent of the symptomatic effect. In addition, the drug appears to be therapeutically safe in the treatment of patients with Parkinson's disease
Phytother Res. 2004 Sep;18(9):706-12.
Neuroprotective effects of the antiparkinson drug Mucuna pruriens.
Manyam BV, Dhanasekaran M, Hare TA.
Department of Neurology, Health Science Center College of Medicine, Temple, TX 76508, USA. [email protected]
Mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson's disease. The present study evaluated the neurorestorative effect of Mucuna pruriens cotyledon powder on the nigrostriatal tract of 6-OHDA lesioned rats. Mucuna pruriens cotyledon powder significantly increased the brain mitochondrial complex-I activity but did not affect the total monoamine oxidase activity (in vitro). Unlike synthetic levodopa treatment, Mucuna pruriens cotyledon powder treatment significantly restored the endogenous levodopa, dopamine, norepinephrine and serotonin content in the substantia nigra. Nicotine adenine dinucleotide (NADH) and coenzyme Q-10, that are shown to have a therapeutic benefit in Parkinson's disease, were present in the Mucuna pruriens cotyledon powder. Earlier studies showed that Mucuna pruriens treatment controls the symptoms of Parkinson's disease. This additional finding of a neurorestorative benefit by Mucuna pruriens cotyledon powder on the degenerating dopaminergic neurons in the substantia nigra may be due to increased complex-I activity and the presence of NADH and coenzyme Q-10.
Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway.
Mandel SA, Avramovich-Tirosh Y, Reznichenko L, Zheng H, Weinreb O, Amit T, Youdim MB.
Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion-Faculty of Medicine, Haifa, Israel.
Many lines of evidence suggest that oxidative stress resulting in reactive oxygen species (ROS) generation and inflammation play a pivotal role in the age-associated cognitive decline and neuronal loss in neurodegenerative diseases including Alzheimer's (AD), Parkinson's (PD) and Huntington's diseases. One cardinal chemical pathology observed in these disorders is the accumulation of iron at sites where the neurons die. The buildup of an iron gradient in conjunction with ROS (superoxide, hydroxyl radical and nitric oxide) are thought to constitute a major trigger in neuronal toxicity and demise in all these diseases. Thus, promising future treatment of neurodegenerative diseases and aging depends on availability of effective brain permeable, iron-chelatable/radical scavenger neuroprotective drugs that would prevent the progression of neurodegeneration. Tea flavonoids (catechins) have been reported to possess potent iron-chelating, radical-scavenging and anti-inflammatory activities and to protect neuronal death in a wide array of cellular and animal models of neurological diseases. Recent studies have indicated that in addition to the known antioxidant activity of catechins, other mechanisms such as modulation of signal transduction pathways, cell survival/death genes and mitochondrial function, contribute significantly to the induction of cell viability. This review will focus on the multifunctional properties of green tea and its major component (-)-epigallocatechin-3-gallate (EGCG) and their ability to induce neuroprotection and neurorescue in vitro and in vivo. In particular, their transitional metal (iron and copper) che
Dirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals
12-11-2009, 01:12 PM
Exactly, It acts to help Parkinson's patients... like testosterone does in hypogonadism. But when You use that for "extra" bennefits, I really don't know if it "blocks" my natural production of dopamine! Even if it is while I am using that... but...
12-11-2009, 01:42 PM
12-11-2009, 01:52 PM
I ran HGHup for about 10 weeks as a baseline... Then added Ghenerate. It's been about 2 weeks on the combination and I can say it's pretty amazing.
I haven't logged it, but it has really ramped things up for me.
I am on the final phase of my shred out right now and I can tell you that I am on the same diet, same training, same thermos as before starting the hghup/ghenerate combo and my bf% loss has been ramped up noticeably, it's really quite impressive. If I was burning fat at level 8 before, this is level 10 or 11, noticeable differences in the mirror ever day.
To top that off strength has gone up, as to where it was stagnate before. So if my strength increases were 0 before, I am at 5-6 now.
LBM gains is hard to say at this point as I no longer measure bodyfat%. But I am up in weight and strength, down in body fat %.
I am around 8%bf right now via the eyeball method. Last actual bodyfat caliper measurement was 10% and was holding there for about 3 weeks.
Only downside as of right now is waking up in the middle of the night. I wake up 2-3 times per night. I'm trying to find a solution for that. But regardless I have awoken reshreshed every morning. And my daily energy levels are phenomenal.
I will be running the combo throughout the final phases of my shredout and will absolutely run it for my rebound lean bulking routine at the end of this month or at the beginning of january. Will definitely do a log that time around.
12-11-2009, 02:21 PM
12-11-2009, 02:47 PM
12-11-2009, 03:05 PM
12-11-2009, 03:38 PM
march 1st I start my h-drol/fura stack and ill be running GHenerate/1-GH-I from week 3 through pct. Im looking forward to trying this product
Your fastest weight is your best weight
12-11-2009, 05:21 PM
I will be running hghup for 8 weeks in the new year as it got the more favoural reveiws from the testers that ran both.
12-11-2009, 09:25 PM
12-12-2009, 10:56 AM
Starting my comeback from injury log with before and after pics. Will be running ghenerate and will look into HGHup after about three months of Ghenerate. Thank you to all for your feedback!
12-12-2009, 11:31 AM
I've tried a lot of HGH over the years and helix-24 from ******* is by far the most effective in my opinion. on top of that, it doesn't give me any cramps like the other products do...
12-12-2009, 11:58 AM
12-13-2009, 10:41 AM
01-21-2010, 07:01 PM
bumping this again! any goods?
I am about to ship hghup + novar combo from nutra, 'cause I think it is good priced, and considering that I am not able to ship GHenerate from LG's site, since I am from Brasil!
But your comments? Does someone as som other also think that HGHup is more effective then GHenerate?
01-21-2010, 07:21 PM
I know a lot of people talk about stacking them, but I would like someone to try maybe doing 3 caps 3 times a day of HGH UP, that would be interesting...
Core Nutritionals Representative
01-21-2010, 07:43 PM
01-21-2010, 07:55 PM
01-21-2010, 08:03 PM
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