Ginko and Prolactin

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    Ginko and Prolactin


    Animal study: ginkgo is prolactin inhibitor (from ergo-log.com)



    Ginkgo biloba supplements decrease the production of the testosterone-inhibiting hormone prolactin in the body, according to Taiwanese researchers in Hormones & Behavior. Ginkgo probably increases the dopamine levels in the brain. Dopamine inhibits the release of prolactin.


    The Taiwanese tested male rats, which were given ginkgo daily for four weeks. The researchers used four groups of animals, which were administered zero, 10, 50 or 100 mg of ginkgo per kg body weight per day. During the month the researchers put the male rats together with female rats and recorded the number of times they had sex. The figure on the right shows the number of times the rats had sex during the last day of the test.


    Because the researchers wanted to know how ginkgo stimulates the sexual behaviour of rats, they measured the testosterone and prolactin levels. The effect was most clear in the group of animals that had received 50 mg per kg body weight a day.






    In high concentrations, prolactin inhibits the production of testosterone. But even when prolactin levels are too low to reduce the production of testosterone, prolactin can still reduce the sex drive. When the researchers examined the brains of the rats in the 50 mg group, they discovered higher concentrations of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid. The Taiwanese researchers think that this is why ginkgo acts as a prolactin inhibitor. They also tested whether ginkgo influences the production of testosterone in the testes directly, but the results were inconclusive.


    Ginkgo decreases cortisol levels after stress 16.08.2008
    Ginkgo protects elderly against first signs of Alzheimer’s 16.08.2008



    Source:
    Horm Behav. 2008 Jan;53(1):225-31.

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    very interesting!
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    dsade reminded me that due to rats increased metabolic rate you must convert rat study dasages by dividing by ~6 to get the proper human dosage. Thus, for me at ~275 lbs. I would require 6 g./day of Ginko based on this study; HOWEVER, you must divide by 6 to get ~ 1 g./day.

    Anyway, dsade suggests 1 g./day divided into 3 doses.

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    Quote Originally Posted by crowbar46 View Post
    dsade reminded me that due to rats increased metabolic rate you must convert rat study dasages by dividing by ~6 to get the proper human dosage. Thus, for me at ~275 lbs. I would require 6 g./day of Ginko based on this study; HOWEVER, you must divide by 6 to get ~ 1 g./day.

    Anyway, dsade suggests 1 g./day divided into 3 doses.

    Crowbar
    i wonder if combining with something like mucuna puriens would reduce amount needed. sounds like a potent one- two punch.
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    do ppl sell ginko powerder, maby usplabs could isolate the active and sellit
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    hmm, may depend on the strength of the powder, but a gram/day seems like alot. if i remember right the powder i had was pretty potent & just a small amount was substantial.
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    Most come in 60mg caps. At least the NOW foods, I shouldnt say most. 1g is a lot..
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    Now also sells 120 mg. caps on Nutraplanet. So, for me weighing ~ 275 lbs. I would need approx. 1 g./day = 9 caps divided into 3 caps 3 x day.

    Remember, the study cites 50 mg./Kg. bodyweight as the most effective dose FOR RATS. Again this dose must be divided by 5-6 to account for the much greater metabolic rate of rats.


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    Quote Originally Posted by crowbar46 View Post
    Now also sells 120 mg. caps on Nutraplanet. So, for me weighing ~ 275 lbs. I would need approx. 1 g./day = 9 caps divided into 3 caps 3 x day.

    Remember, the study cites 50 mg./Kg. bodyweight as the most effective dose FOR RATS. Again this dose must be divided by 5-6 to account for the much greater metabolic rate of rats.


    Crowbar
    The study probably used full-spectrum ginkgo. In most human studies, 240 mgs of the 24% extract is the upper limit used. You might use more due to your size, but again, one gram sounds like alot to me if using the 24% extract.
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    Sorry guys, you're right. Seth Roberts cleared it up: say you weigh 220 lbs.=100Kg.. You take your weight in Kg.=100 x 10 mg. (1/5 the most effective dosage in the rat studies, in order to adjust for rats having a much greater metabolic rate)= 1000 mg. Now if your extract is a 50:1 extract (which the NOW brand is), a 60 mg. cap of extract is produced from 3 g. of Ginko--much more than the 1 g. you need.

    In other words seth was saying that one 60 mg. cap/day should be enough to see prolactin inhibiting effects in anyone.

    Pop those caps!


    Crowbar
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    Quote Originally Posted by crowbar46 View Post
    Sorry guys, you're right. Seth Roberts cleared it up: say you weigh 220 lbs.=100Kg.. You take your weight in Kg.=100 x 10 mg. (1/5 the most effective dosage in the rat studies, in order to adjust for rats having a much greater metabolic rate)= 1000 mg. Now if your extract is a 50:1 extract (which the NOW brand is), a 60 mg. cap of extract is produced from 3 g. of Ginko--much more than the 1 g. you need.

    In other words seth was saying that one 60 mg. cap/day should be enough to see prolactin inhibiting effects in anyone.

    Pop those caps!


    Crowbar
    seth seems to know what he is talking about with prolactin. was a real good thread going for awhile, it may still be going?
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    cool stuff. i always kind of liked the ginko, it does seem to boost the blood flow to the brain significantly/noticably. great with your morning stim stack.
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    Yeah, I'll be adding Ginko to the next cycle where I use any "tren" product. Did you also catch the reference at the end of the study outline about Ginko lowering cortisol; makes sense that Ginko would lower both prolactin and cortisol if the researchers are right and Ginko is a Dopamine agonist.

    Crowbar
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    whats the best source for cheap ginko? can you pick up the ones at rite aid or are those crap? im very interested in controling my prolactin levels any way possible.
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    Quote Originally Posted by crowbar46 View Post
    Yeah, I'll be adding Ginko to the next cycle where I use any "tren" product. Did you also catch the reference at the end of the study outline about Ginko lowering cortisol; makes sense that Ginko would lower both prolactin and cortisol if the researchers are right and Ginko is a Dopamine agonist.

    Crowbar
    did past tren usage elevate your prolactin or was it just during?
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    To be honest, I don't really seem to have as much of a problem on cycle with "tren" products; but they really kill my libido and shut me down hard after the cycle.

    I think I would stick with a known quality brand. Nutra carries the NOW brand. At any rate you want to make sure your Ginko product is a standardized extract of the following potency: 24% Ginkgoflavonglycosides and min. 6% Terpene Lactones. If it does not specifically state these standardized potencies, then do NOT buy it.

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    Gingko biloba is traditionally a nootropic. It is reknown for increasing concerntration by vasodilation (in the brain). Its one of the few noots that works on almost everyone.

    World memory champ. uses it before world record attempts.

    Its good to see its good broader spectrum usage. Wonder how it works? I just buy bulk powder and cap. Tastes awful.
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    As the article states, it appears to be a dopamine agonist.

    Crowbar
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    Quote Originally Posted by crowbar46 View Post
    Sorry guys, you're right. Seth Roberts cleared it up: say you weigh 220 lbs.=100Kg.. You take your weight in Kg.=100 x 10 mg. (1/5 the most effective dosage in the rat studies, in order to adjust for rats having a much greater metabolic rate)= 1000 mg. Now if your extract is a 50:1 extract (which the NOW brand is), a 60 mg. cap of extract is produced from 3 g. of Ginko--much more than the 1 g. you need.

    In other words seth was saying that one 60 mg. cap/day should be enough to see prolactin inhibiting effects in anyone.

    Pop those caps!


    Crowbar
    so you're saying one 60mg of 50:1 extract is enough? I dont think so...I have elevated prolactin levels and I took gingko biloba before for about 6 months straight at about 240mg a day and didnt see any effect.
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    not everyone is going to respond the same, especially to a non-pharmaceutical; you're a perfect example, if you didn't respond to 240 mg.--if it was a quality standardized extract--you're not likely to benefit from Ginko period (at least not for this application).


    Crowbar

    P.S. I also advise anyone to use 3-4 x day (180 mg.-240 mg.), due to its short half-life and it's inexpensive and safe at these dosages.
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    hmmmm i am in AUStralia so we dont have all the fancy stuff. What i do have is
    2000mg ginkgo, but it is 10.68mg flavonglycosides and 2.68mg bilobalide per cap...

    how many of these to get the 1g magic amount???
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