The Future of Nutrient Delivery - Liqua-Vade

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    Exclamation The Future of Nutrient Delivery - Liqua-Vade


    Dear AM,

    Primordial Performance is proud to present their new Liqua-Vade™ nutrient delivery technology. Liqua-Vade is literally a liquid nutrient invasion.



    Liqua-Vade technology is based off a pharmaceutical drug delivery technology known as a Self Emulsifying Drug Delivery System (SEDDS). (1-15) This technology was designed to enhance absorption of poorly water soluble compounds. This includes various hormones, flavonoids, and fat soluble vitamins (carotenoids, vitamin E, CoEnzyme Q-10, ect)

    The technology enhances delivery of poorly soluble compounds by dissolving and making them highly dispersed in the digestive track. To see exactly how Liqua-Vade solubilizes poorly water soluble compounds, visit this page – Liqua-Vade



    Here are a few clinical trials of Liqua-Vade technology (SEDDS) enhancing delivery of poorly water soluble nutrients –

    Poorly water soluble vitamin (CoQ10) -


    Steroid hormone -


    Isoflavone from kudzu root -


    Flavone from silymarin (milk thistle extract) -


    I’d like to thank you for reading this special announcement from Primordial Performance.

    Yours in health & fitness,

    Eric Potratz
    Primordial Founder & President

    Questions?

    Phone – 1-800-568-2924
    Email - info@primordialperformance.com
    Visit - Primordial Performance


    References –

    1. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs.
    Porter C, et al
    Nat Rev Drug Discov 2007 Mar;6(3):231-48

    2. Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine.
    Odeberg et al.
    Eur J Pharm Sci. 2003 Dec;20(4-5):375-82

    3. Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    Constantinides PP et al.
    Pharm Res. 1995 Nov;12(11):1561-72

    4. Self-microemulsifying drug delivery systems (SMEDDS) for improving in vitro dissolution and oral absorption of Pueraria Lobata isoflavone.
    Cui et al.
    Drug Dev Ind Pharm. 2005 May;31(4-5):349-56.

    5. Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs.
    Gao P, et al.
    Expert Opin Drug Deliv. 2006 Jan;3(1):97-110

    6. Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems.
    Balakrishnan P, et al.
    Int J Pharm. 2009 Jun 5;374(1-2):66-72.

    7. Clinical studies with oral lipid based formulations of poorly soluble compounds.
    Fatouros DG, et al
    Ther Clin Risk Manag. 2007 Aug;3(4):591-604

    8. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
    R. Nesliham et al.
    Biomed Pharmacother. 2004 Apr;58(3):173-82. Review.

    9. Formulation of lipid-based delivery systems for oral administration: Materials, methods, and strategies
    Pouton CW et al.
    Adv Drug Deliv Rev. 2008 Mar 17;60(6):625-37. Epub 2007 Nov 4

    10. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound.
    Susan et al.
    Pharm Res. 1992 Jan;9(1):87-93.

    11. Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water soluble drug
    Greg A et al.
    J Pharm Sci. 2005 Mar;94(3):481-92.

    12. Cyclosporin nanoparticulate lipospheres for oral absorption
    Tania et al.
    J Pharm Sci. 2004 May;93(5):1264-70

    13. Self-Emulsifying Drug Delivery Systems: Strategy for improving oral delivery of poorly water soluble drugs.
    Jing et al.
    Current Drug Therapy, 2007, 2, 85-93

    14. Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin.
    Quan DQ, et al.
    Chem Pharm Bull (Tokyo). 2007 May;55(5):800-3

    15. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.
    Wu W, et al
    2006 Jul;63(3):288-94. Epub 2006 Mar 9

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    """"Alternative to topical creams for higher absorption and less mess """

    THANK GOD!!
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    VERY intriguing and nice job Pp!!!
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    Thanks guys..

    Forgive the website issues... it will be ironed out in the next few minutes.. just migrated over to the new site and dedicated server.

    -Eric
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    Glad to see the oral products coming out
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    Here is an interview I just did with Carl on Liqua-Vade.

    mods - all non-AM advertising removed

    -Eric
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    I like this product.
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    Can this delivery system work with any herbs etc aminos etc?
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    this sounds great Eric.
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    do you will launch an oral "Liqua-Vade" version of all of your topical products?
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    Quote Originally Posted by djbombsquad View Post
    Can this delivery system work with any herbs etc aminos etc?
    Its designed for poorly water soluble compounds, which is basically any compound with a logP 2 or higher. There are plenty of herbal constituents that will work well with Liqua-Vade.

    -Eric
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    Quote Originally Posted by JBerto View Post
    do you will launch an oral "Liqua-Vade" version of all of your topical products?
    Once we get initial feedback on the Oral Sustain we will consider opening up the Dermacrine and 1-T to the technology.

    -Eric
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    Quote Originally Posted by Primordial Perf View Post
    Once we get initial feedback on the Oral Sustain we will consider opening up the Dermacrine and 1-T to the technology.

    -Eric
    SWEET, i really hope all these great innovations r still around when i get out of training!
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    What about Toco-8 or Endo-amp in this?
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    Quote Originally Posted by Urban Monk View Post
    What about Toco-8 or Endo-amp in this?
    EndoAmp being a phospholipid is already fairly well absorbed. The Toco-8 is already in a semi-SEDDS delivery form being that its combined with an emulsifying agent. (low % of PS-20 I believe)

    -Eric
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    what about creatine mono? ecdy?
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    Quote Originally Posted by Primordial Perf View Post
    Once we get initial feedback on the Oral Sustain we will consider opening up the Dermacrine and 1-T to the technology.

    -Eric
    Will Liqua-Vade be sold standalone? I cannot find it as a product on your website.
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    Quote Originally Posted by strategicmove View Post
    Will Liqua-Vade be sold standalone? I cannot find it as a product on your website.
    I am with you there Ike...I am liking what I am reading about this new technology.

    Cheers!
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    subbed for info
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    Quote Originally Posted by alwaysgaining View Post
    what about creatine mono? ecdy?
    Creatine mono - maybe... but Im not sure the logP on this one. If its over 2 then yes it will help.

    Ecdy? Which one? Again... if the logP value if over 2 for the compound you are talking about then it can work with this technology.

    -Eric
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    Quote Originally Posted by strategicmove View Post
    Will Liqua-Vade be sold standalone? I cannot find it as a product on your website.
    We dont sell it as a stand alone.. yet.

    This is something we willl look into as we work on building this for our other products like Dermacrine and 1-T.

    Would you guys have interest in that?

    -Eric
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    i would be for sure
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    Quote Originally Posted by Primordial Perf View Post
    ...

    Would you guys have interest in that?

    -Eric
    Most certainly.
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    I thought the whole point of Dermacrine was to get the enzymatic conversion of the dhea through the skin to other compounds.
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    Quote Originally Posted by Primordial Perf View Post
    We dont sell it as a stand alone.. yet.

    This is something we willl look into as we work on building this for our other products like Dermacrine and 1-T.

    Would you guys have interest in that?

    -Eric
    Big time interest.
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    Quote Originally Posted by bigmoe65 View Post
    I thought the whole point of Dermacrine was to get the enzymatic conversion of the dhea through the skin to other compounds.
    this wAs my understanding too but anything fhats more effective and affordable I'm all about as long as its effective
    I have used all primordials products and liked them all
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    We will run some trial batches on oral Dermacrine and 1-T soon and see how this pans out... stay tunned.

    -Eric
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    Quote Originally Posted by Primordial Perf View Post
    We will run some trial batches on oral Dermacrine and 1-T soon and see how this pans out... stay tunned.

    -Eric
    great news
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    It was suggested to add formestane to the oral sustain alpha. I don't know much about solubility/saturation though.
    How much formestane could a bottle of the oral sustain take? And would it have an effect?
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    Quote Originally Posted by Urban Monk View Post
    It was suggested to add formestane to the oral sustain alpha. I don't know much about solubility/saturation though.
    How much formestane could a bottle of the oral sustain take? And would it have an effect?
    You could try to measure out your dose and just mix it with the SA bottle. This isnt ideal, but it should help absorption of the formestane to some degree... to what extent I couldnt say...

    -Eric
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    to bad this delivery system wasnt out before all the crack down on PH/DS i could only imagine how much more potent it could have made them.
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    Personally, I'm thinking X-Lean + Liquivade would be quite something.

    I'ma go harrass babywifey about that stuff again...
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    Does this delivery system cause any stress to the liver?
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    Quote Originally Posted by rich2342 View Post
    Does this delivery system cause any stress to the liver?
    No way... we are dealing with food grade sorbitan esters and fatty acids... very safe and natural stuff.

    Its really just increasing solubility and allowing the ingredients to reach the biological membranes so they can absorb.

    -Eric
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    How long until a "line" of other similarly created anabolic goodies?
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    Quote Originally Posted by Whacked View Post
    How long until a "line" of other similarly created anabolic goodies?
    We will be starting production of Liqua-Vade Dermacrine and 1-T next week to run a couple trials.

    -Eric
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    YUM
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    Quote Originally Posted by Primordial Perf View Post
    We will be starting production of Liqua-Vade Dermacrine and 1-T next week to run a couple trials.

    -Eric
    for you Eric
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    Will the dosing be the same? 5 on 2 off?

    What about long term continued use in the above fashion? Any risk of shut down?
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    Quote Originally Posted by rich2342 View Post
    Will the dosing be the same? 5 on 2 off?

    What about long term continued use in the above fashion? Any risk of shut down?
    5 on, 2 off will remain the same for Sustain Alpha... which doesnt cause any kind of shutdown... it just allows your body to respond to the product better.

    Guys have continually used Sustain Alpha for several months (or even years). There is no health consequence to it.

    -Eric
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