Cissus Quadrangularis' effect on the liver?

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    Cissus Quadrangularis' effect on the liver?


    Anyone have any solid information for the affects on the liver if any when supplementing Cissus? It never crossed my mind until I read this excerpt Cissus quadrangularis

    Cissus also possess analgesic properties on a mg per mg basis comparable to aspirin or anti-inflammatory drugs like ibuprofen. Cissus quadrangularis constitutes one of the ingredients of an Ayurvedic preparation, `Laksha Gogglu', which has been proved to be highly effective in relieving pain, reduction of swelling and promoting the process of healing of the simple fractures as well as in curing the allied disorders associated with fractures (7). The mechanism through which Cissus exerts its analgesic and anti-inflammatory properties has not been well characterized. It may act centrally, but the anti-inflammatory features suggest that it acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins.

    One would suspect with similar properties as OTC pain relievers it would put some strain on the liver to some extent or else might have issues if mixed with Ibuprofen/tylenol etc

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    Acetaminophen is the main NSAID that puts stress on the liver and it's mainly an antipyrrhetic. This is also a tad faulty in logic as well. For example, omega-3 EFAs have been shown to be anti-inflammatory as well.
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    I'm aware of omega 3 being anti inflammatory, but I'm having trouble finding anything on the net besides here that says if there are any side effect of long term usage or mixability with other drugs. Just wanna be sure before I recommend this to other people who are using perscription medication.
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    Quote Originally Posted by Jessep76 View Post
    I'm aware of omega 3 being anti inflammatory, but I'm having trouble finding anything on the net besides here that says if there are any side effect of long term usage or mixability with other drugs. Just wanna be sure before I recommend this to other people who are using perscription medication.
    I highly doubt that there is any data on this subject. Most of the studies on cissus are Indian and not very long term.
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    Not true. tHere are English studies, but they center around fat loss, not joint repair. I've never seen any cissus study show any negative changes in any of the usual markers.
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    Reactive oxygen species, neutrophil infiltration and proinflammatory cytokines play an important role in the pathogenesis of gastric ulcers caused by aspirin. The present study demonstrates the healing effect of Cissus quadrangularis extract (CQE) through inhibitory action on generation of lipid peroxidation, proinflammatory cytokines and neutrophil infiltration. The concentration of malondialdehye (MDA), protein carbonyl content, conjugated dienes, mucosal (SH) sulphydryls, uric acid, tumor necrosis factor-alpha (TNF-alpha), and activities of myeloperoxidase (MPO), xanthine oxidase (XO) and antioxidative enzymes were determined in the gastric mucosa. Administration of CQE significantly attenuated the gastric lesions induced by aspirin and this was accompanied by the rise in uric acid, antioxidative enzymes, SH groups, and a significant decrease in lipid peroxidase, TNF-alpha, MPO and XO activities. These findings suggest that the significant gastroprotective activity could be mediated by the antioxidant activity as well as by the attenuation of oxidative mechanism and proinflammatory cytokines.
    Re: Efficacy of a Cissus quadrangularis Formulation in the Treatment of Weight Loss and the Metabolic Syndrome
    Oben J, Kuate D, Agbor G, Momo C, Talla X. The use of Cissus quadrongularis formulation in the management of weight loss and metabolic syndrome. Lipids in Health and Disease. 2006;5(24):1-7.

    The metabolic syndrome, also commonly known as insulin resistance syndrome, is a disorder that has become common in the United States and worldwide as a result of the increased prevalence of obesity. As of 2003, more than 60% of the adult US population was overweight or obese, and 47 million people had the metabolic syndrome. Globally, this syndrome has become a major public health problem because obesity is associated with high serum triglycerides, low serum HDL cholesterol, and hyperglycemia all of which are associated with an increased risk of cardiovascular disease. Total cholesterol and LDL cholesterol are additional cardiovascular risk factors. Pharmacotherapeutic options have been used in the treatment of obesity. However, adverse effects have led to the withdrawal of some of these medications from the marketplace. Because of safety concerns and high costs, many populations are seeking natural therapies to aid with weight loss. The objective of this study was to evaluate the efficacy of a Cissus quadrangularis formulation (CylarisTM; Gateway Health Alliances, Inc., Fairfield, CA) in the management of weight loss and the metabolic syndrome. In addition to a C. quadrangularis extract standardized to contain a minimum of 2.5% phytosterols and of 15% soluble plant fiber, the formulation contained soy (Glycine max) albumin extract, a green tea (Camellia sinensis) extract standardized to 22% epigallocatechin gallate and 40% caffeine, niacin-bound chromium, selenium standardized to 0.5% l-selinomethionin, vitamin B6 (as pyridoxine hydrochloride), vitamin B12 (as cynaocobalamin), and folic acid.

    This prospective, randomized, double-blind, placebo-controlled study was conducted at the Laboratory for Nutrition and Nutritional Biochemistry at the University of Yaoundé I, Cameroon, Africa. Obese men and women (n = 92) aged 19–50 years were randomly assigned to 3 groups: placebo, C. quadrangularis formulation plus no dietary intervention (usual diet), or C. quadrangularis formulation plus dietary intervention (a calorie-controlled diet providing 2100–2200 calories/day) for 8 weeks. Overweight men and women (n = 31) comprised a fourth group, which received C. quadrangularis formulation plus no dietary intervention. The C. quadrangularis formulation was provided as 2 daily doses of 514 mg each, taken with water before breakfast and dinner. Body weight, percentage body fat, waist circumference, and cholesterol, C-reactive protein, glucose, and triglyceride concentrations were measured at baseline and at week 8. A P value <0.05 indicated significance.

    Waist circumference decreased significantly by week 8 in all treatment groups. Body weight and body mass index decreased significantly in the 2 obese groups. Over 8 weeks, the placebo group lost 2.3.kg, the overweight group lost 3.7 kg, and the 2 obese groups lost 6.6 and 8.1 kg of body weight. Plasma total cholesterol and LDL cholesterol decreased significantly in the 3 treatment groups, and HDL cholesterol increased significantly in the 2 obese groups. Triglyceride, C-reactive protein, and glucose concentrations also decreased significantly in the 3 treatment groups. Some adverse effects were reported; however, the incidence of all reported side effects was higher in the placebo than in the treatment groups; thus, the authors concluded that the side effects were not associated with C. quadrangularis treatment.

    The results help support the authors' hypothesis that the use of a C. quadrangularis formulation is efficacious in the management of weight loss, total cholesterol, LDL cholesterol, and the metabolic syndrome. Treatment with C. quadrangularis for 8 weeks resulted in weight reduction, total cholesterol reduction, LDL cholesterol reduction, and improvements in the symptoms of the metabolic syndrome. The drastic reduction in waist circumference after 8 week of C. quadrangularis use in both the dietary intervention and nondietary intervention groups was a particularly important finding because waist circumference is the major criterion used to diagnose obesity and the metabolic syndrome. The authors suggest that C. quadrangularis "may also have applications in other metabolic diseases, such as diabetes mellitus."
    And for more info search these:

    Chopra SS, Patel MR, Awadhiya RP.
    Related Articles, Links
    No Abstract Studies of Cissus quadrangularis in experimental fracture repair : a histopathological study.
    Indian J Med Res. 1976 Sep;64(9):1365-8. No abstract available.
    PMID: 1010630 [PubMed - indexed for MEDLINE]
    48:
    Chopra SS, Patel MR, Gupta LP, Datta IC.
    Related Articles, Links
    No Abstract Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in blood.
    Indian J Med Res. 1975 Jun;63(6):824-8. No abstract available.
    PMID: 1213779 [PubMed - indexed for MEDLINE]
    49:
    UDUPA KN, PRASAD G.
    Related Articles, Links
    No Abstract BIOMECHANICAL AND CALCIUM-45 STUDIES ON THE EFFECT OF CISSUS QUADRANGULARIS IN FRACTURE REPAIR.
    Indian J Med Res. 1964 May;52:480-7. No abstract available.
    PMID: 14175605 [PubMed - OLDMEDLINE]
    50:
    DAS PK, SANYAL AK.
    Related Articles, Links
    No Abstract STUDIES ON CISSUS QUADRANGULARIS LINN. I. ACETYLCHOLINE LIKE ACTION OF THE TOTAL EXTRACT.
    Indian J Med Res. 1964 Jan;52:63-7. No abstract available.
    PMID: 14112165 [PubMed - indexed for MEDLINE]
    51:
    UDUPA KN, PRASAD GC.
    Related Articles, Links
    No Abstract FURTHER STUDIES ON THE EFFECT OF CISSUS QUADRANGULARIS IN ACCELERATING FRACTURE HEALING.
    Indian J Med Res. 1964 Jan;52:26-35. No abstract available.
    PMID: 14112159 [PubMed - indexed for MEDLINE]
    52:
    PRASAD GC, UDUPA KN.
    Related Articles, Links
    No Abstract EFFECT OF CISSUS QUADRANGULARIS ON THE HEALING OF CORTISONE TREATED FRACTURES.
    Indian J Med Res. 1963 Jul;51:667-76. No abstract available.
    PMID: 14073618 [PubMed - OLDMEDLINE]
    53:
    SINGH LM, UDUPA KN.
    Related Articles, Links
    No Abstract Studies on "Cissus Quadrangularis" in fracture by using phosphorus 32. III.
    Indian J Med Sci. 1962 Nov;16:926-31. No abstract available.
    PMID: 13977656 [PubMed - indexed for MEDLINE]
    54:
    UDUPA KN, PRASAD GC.
    Related Articles, Links
    No Abstract Cissus quadrangularis in healing of fractures. A clinical study.
    J Indian Med Assoc. 1962 Jun 1;38:590-3. No abstract available.
    PMID: 13923449 [PubMed - OLDMEDLINE]
    55:
    UDUPA KN, ARNIKAR HJ, SINGH LM.
    Related Articles, Links
    No Abstract Experimental studies of the use of 'cissus quadrangularis' in healing of fractures. II.
    Indian J Med Sci. 1961 Jul;15:551-7. No abstract available.
    PMID: 13778943 [PubMed - OLDMEDLINE]
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    bad ass.
    Would an extract of 40% just be more efficient than 20% or are other benefits brought about through higher standardizations?
  

  
 

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