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Novel Methods to Reduce Stubborn Belly Fat - Life Extension
As highlighted below, delivering targeted ingredients directly into the skin has one key objective: to initiate lipolysis using a strategy that does not depend on beta-adrenoreceptor activation, since subcutaneous fat cells have a lower concentration of beta adrenoreceptors (which stimulate lipolysis) and a higher concentration of alpha adrenoreceptors (which inhibit lipolysis). This can be achieved with active ingredients that:
* Prevent the storage of more fat in subcutaneous adipocytes (anti-adipogenesis effect). A specific strategy that accomplishes this is the inhibition of an enzyme called lipoprotein lipase, which normally acts on triglycerides within lipoproteins, breaking them down into free fatty acids to be stored as fat.
* Stimulate the release of currently stored fat in subcutaneous adipocytes (pro-lipolytic effect) by:
- Activating an enzyme called adenylate cyclase, which increases levels of cyclic AMP (an important cell-regulating compound and a key lipolytic activator) within fat cells. The resulting high tissue concentrations of cAMP activate a fat-breakdown hormone called hormone-sensitive lipase, which promotes lipolysis.23
- Reducing the degradation of cAMP within fat cells.
* Prevent the maturation of pre-adipocytes into mature fat cells, capable of storing large amounts of fat (anti-differentiation effect).
* Can be applied topically to target subcutaneous fat cells just under the skin, rather than through an oral systemic stimulant.
* Include complementary ingredients to simultaneously encourage collagen and elastin synthesis, restoring youthful tone to thinning or sagging skin.
Increasing cAMP while inhibiting Lipoprotein Lipase
Xantalgosil C® is designed to promote subcutaneous lipolysis. It contains a synergistic combination of organic silicon and a xanthic base (similar to the caffeine and theophylline found in green tea) that activates lipolysis by increasing cAMP and prevents further fat storage by inhibiting lipoprotein lipase. Xantalgosil C® also improves microcirculation, reduces inflammation, and yields firmer skin.24 In a study conducted on 25 non-obese patients aged 22-54 years old, Xantalgosil C® reportedly improved skin appearance within two months of use. In addition, more than half of the treated subjects lost nearly two inches from around the waist.24
As highlighted below, delivering targeted ingredients directly into the skin has one key objective: to initiate lipolysis using a strategy that does not depend on beta-adrenoreceptor activation, since subcutaneous fat cells have a lower concentration of beta adrenoreceptors (which stimulate lipolysis) and a higher concentration of alpha adrenoreceptors (which inhibit lipolysis). This can be achieved with active ingredients that:
* Prevent the storage of more fat in subcutaneous adipocytes (anti-adipogenesis effect). A specific strategy that accomplishes this is the inhibition of an enzyme called lipoprotein lipase, which normally acts on triglycerides within lipoproteins, breaking them down into free fatty acids to be stored as fat.
* Stimulate the release of currently stored fat in subcutaneous adipocytes (pro-lipolytic effect) by:
- Activating an enzyme called adenylate cyclase, which increases levels of cyclic AMP (an important cell-regulating compound and a key lipolytic activator) within fat cells. The resulting high tissue concentrations of cAMP activate a fat-breakdown hormone called hormone-sensitive lipase, which promotes lipolysis.23
- Reducing the degradation of cAMP within fat cells.
* Prevent the maturation of pre-adipocytes into mature fat cells, capable of storing large amounts of fat (anti-differentiation effect).
* Can be applied topically to target subcutaneous fat cells just under the skin, rather than through an oral systemic stimulant.
* Include complementary ingredients to simultaneously encourage collagen and elastin synthesis, restoring youthful tone to thinning or sagging skin.
Increasing cAMP while inhibiting Lipoprotein Lipase
Xantalgosil C® is designed to promote subcutaneous lipolysis. It contains a synergistic combination of organic silicon and a xanthic base (similar to the caffeine and theophylline found in green tea) that activates lipolysis by increasing cAMP and prevents further fat storage by inhibiting lipoprotein lipase. Xantalgosil C® also improves microcirculation, reduces inflammation, and yields firmer skin.24 In a study conducted on 25 non-obese patients aged 22-54 years old, Xantalgosil C® reportedly improved skin appearance within two months of use. In addition, more than half of the treated subjects lost nearly two inches from around the waist.24
