Alpha1 Agrenergic Receptor Agonists
- 06-24-2009, 05:10 AM
- 06-24-2009, 04:23 PM
06-24-2009, 05:28 PM
Its a very specific question .. why?
alpha-2 receptor -
I presume is what you are after.
Uses fat-burner (cutting). Okay so why wanna know?
06-24-2009, 05:48 PM
06-25-2009, 05:04 AM
06-25-2009, 05:05 AM
06-25-2009, 09:31 AM
Okay ... educate us. From my knowledge you anagtonise the alpha receptors you get jump, more focussed and alert. What is the difference then between receptors 1,2 and 3?
Its hard enough to target a group of receptors to hit a specific receptor as opposed to 2 and 3 is a big ask.
So what answer did you receive?
The answer to the question is fat-burning, but what was the question?
06-25-2009, 02:49 PM
06-25-2009, 05:32 PM
Very interesting indeed. Thanks.
According to the wiki the specificity prevents activation of norephinephrine (noradrenalin). SO it ain't a fat burnerwhich I though it would be, but for vasodilation it looks good.
I'll give it a go to clear my sinuses and see what else happens besides. It is useful to know because if you've a specific receptor reaction (pretty rare) you can be confident there will be no none specific side-effects.
06-25-2009, 05:49 PM
06-25-2009, 06:03 PM
06-25-2009, 06:07 PM
06-26-2009, 03:45 AM
06-26-2009, 12:16 PM
06-28-2009, 03:56 PM
06-28-2009, 05:48 PM
06-28-2009, 06:14 PM
06-29-2009, 02:31 PM
Selective alpha-1 agonism would cause an unwelcome increase in blood pressure. It is one of the main adrenergic regulatory pathways for BP (constricts smooth muscle, in particular in the vascular system...arterioles, venules, and coronary arteries). Norepinephrine, epinephrine, etc activates alpha1, which is why they result in vasoconstriction and increased BP.
I would suspect that there is no relevant use for a selective alpha1 agonist in bodybuilding/powerlifting/anything without a medical use.
Alpha 2 is activated by norE as a negative feedback loop...agonism of alpha2 receptors leads to downregulation of NorE release, as well as vasoconstriction. Hence selective blocking of alpha2 (a la alpha-yohimbine) will lead to less downregulation of norE release, among other things.
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