Looks an unfamiliar word but it is appearing more and more in supplement formulations, Drive , RPM just 2 examples.
For those that dont know , it is an extract of grapefruit and according to Wikipedia can have the following effect
Naringin exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions in vivo.[1] Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (esp. grapefruit) and other juices with medications is contraindicated. [2]
My questions are does it aid or hinder the absorbtion of the other ingredients?
If taking a designer or ph or AI would it again aid or hinder absorbtion even if not taken together?
Without detailed studies on various products as to which way naringin has an effect, how do we know.
One final thought , for those who are concerned about reducing estrogen , in his book "The testosterone syndrome " Dr Shippen advises against eating grapefruit because it inhibits "the P450 phase 1 system resulting in increased estrogen levels"
For those that dont know , it is an extract of grapefruit and according to Wikipedia can have the following effect
Naringin exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions in vivo.[1] Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (esp. grapefruit) and other juices with medications is contraindicated. [2]
My questions are does it aid or hinder the absorbtion of the other ingredients?
If taking a designer or ph or AI would it again aid or hinder absorbtion even if not taken together?
Without detailed studies on various products as to which way naringin has an effect, how do we know.
One final thought , for those who are concerned about reducing estrogen , in his book "The testosterone syndrome " Dr Shippen advises against eating grapefruit because it inhibits "the P450 phase 1 system resulting in increased estrogen levels"