Vat Attack! By USPowders, Get Super Lean for Super Cheap! Write up and Q&A

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    Vat Attack! By USPowders, Get Super Lean for Super Cheap! Write up and Q&A



    USPowders Q & A: VAT Attack!

    VAT attack! is without a doubt one of the most innovative powders to hit the weight loss scene. USPowders, a subsidiary of USPlabs is the forefront of the innovative side of the bulk powder game. Itĺs rarely seen in our industry that a company releases innovation at an economical and cost effective way.

    Iĺm about to tell you why you need VAT Attack! the ONLY Non-Hormonal way to combat visceral adipose tissue (VAT). VAT is the "blubber" deep down that when reduced is the only way to get the deep ripped defined physique!

    Glucocorticoids are recognized as stress hormones that mediate a myriad of physiological pathways that are implicated in inflammatory, metabolic, and cardiovascular processes. An excessive expression of glucocorticoids can lead to obesity, hypertension (and other cardiovascular dysfunctions), dyslipidemia, impaired insulin metabolism, and other inflammatory states.

    Now, cortisol (corticosterone), a catabolic hormone released in the adrenal cortex, is the main (active) glucocorticoid form in humans. Two proteins are known to mediate glucocorticoid action. One is corticosteroid-binding globulin (CBG), and the other is 11▀-hydroxysteroid dehydrogenase. The protein, 11▀-HSD has two isoenzymes that regulate the interconversion of cortisol and cortisone at the endoplasmic reticulum.

    These two isoenzymes, 11▀-HSD type 1 and 11▀-HSD type 2, are not only produced by different genes, but also have different tissue distribution. More specifically, 11▀-HSD1 is primarily distributed in the liver, the kidneys, the brain, and in adipose cells; while 11▀-HSD2 is mainly found in the kidney and the salivary glands. In humans, 11▀-HSD1 is responsible for the conversion of inactive cortisone to cortisol, while 11▀-HSD2 is mediates the catalysis of the opposite reaction. Cortisol is primarily converted into the inert glucocorticoid, cortisone, in the kidney. Cortisol accumulation occurs via a combination of tissue 11▀-HSD1 activity and plasma diffusion. Plasma glucocorticoid levels are mediated by the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and can be triggered by stress, both physical and psychological.

    The glucocorticoid receptor mediates glucocorticoid action and, consequently, activates or deactivates target genes involved in such physiological processes as adipocyte differentiation, inflammation, and gluconeogenesis. Examples of these target genes include glucose-6-phosphatase [G6Pase], tyrosine aminotransferase (TAT), leptin, hormone sensitive lipase (HSL), lipoprotein lipase (LPL), corticotrophin-releasing hormone (CRH), interleukin 6 (IL-6), prolactin, and so on.

    Clearly, 11▀-HSD1 activity is important for the regulation of cortisol levels. In particular, 11▀-HSD1 inhibition leads to a series of effects including increased fat loss, reduction in hyperglycemia and hepatic glucose output (via reduced expression of glucose-6-phosphatase [G6Pase] and phosphoenolpyruvate carboxykinase [PEPCK], the rate-limiting enzymes in gluconeogenesis), reduced hepatic fat accumulation (via reduction in the differentiation of pre-adipocytes to adipocytes, reduction of the activities of enzymes involved in fatty-acid synthesis and triglyceride accumulation), improved peripheral insulin sensitivity (via reversal of glucocorticoid antagonism of insulin-stimulated glucose disposal), reduction of visceral adipose tissue fat accumulation, and favorable changes in other metabolic indicators. Note that fat accumulation can occur either via increase in the size of individual adipocytes (large adipose cells are more insulin insensitive), or an increase in the number of adipocytes (via adipose differentiation from pre-adipocytes to adipocytes). Or both!

    We have seen that cortisol management is desirable to mitigate metabolic disturbances. We have also established that 11▀-HSD1 is the key regulatory enzyme for cortisol synthesis, and that the inhibition of this enzyme, in the presence of physiological and psychological stress stimuli, will favorably induce a myriad of beneficial results, including improved (visceral) fat loss, improved insulin sensitivity, improved cardiovascular state, and enhanced lean mass preservation.

    But how can we achieve 11▀-HSD1 via non-hormonal means? Enter VAT Attack! Contained in VAT Attack!, Coffee (Coffea Arabica L.) extract is known to support lipid and glucose metabolism via selectively inhibiting the action of 11▀-HSD1 (but not that of 11▀-HSD2), leading to physiological processes enumerated earlier. Elevated cortisol levels are known to induce breakdown of muscle tissue.

    Essentially, cortisol exerts a metabolic action by elevating glucose levels during exercise, for instance, via inducing protein (amino acid) and lipid mobilization in adipocytes and skeletal muscle cells. Beyond this, cortisol stimulates hepatic production of enzymes that mediate gluconeogenic, glycogenetic, and related pathways.

    This leads to conversion of amino acids and glycerol into glucose and glycogen. In this instance, cortisol acts much like insulin as a non-discriminatory storage hormone. Clearly, the metabolic action of cortisol ultimately leads to adipose-cell accumulation, especially of the visceral-adipose-tissue type.

    What can you expect from VAT Attack!?
    • Significant and noticeable reduction in elevated cortisol levels via selective 11▀-HSD1 inhibition.
    • Dramatic increase in lipolytic action within the deep visceral-adipose-tissues (VAT), leading to a significant trimming of VAT accumulation, inducing noticeable fat loss, and bringing you closer to your desired six-pack.
    • Enhanced ôburningö of subcutaneous adipose tissue (SCAT), triggering a cascade of events that ultimately deliver noticeable fat loss.
    • Preservation of lean mass by reducing the action of the catabolic hormone, cortisol.
    • Enhanced cellular insulin sensitivity, leading to the breakdown of another supportive factor in weight gain.
    • Elevation of the markers of optimal cardiovascular and endothelial functions.
    • Improvement in the testosterone:cortisol ratio, following the strong negative correlation between testosterone (total and free) and cortisol.


    By selectively inhibiting the action of 11▀-HSD1, VAT Attack! supports a significant reduction in cortisol levels, leading to such favorable outcomes as generalized and abdominal (visceral-adipose-tissue and subcutaneous-adipose-tissue) fat loss, improved insulin sensitivity, and increased testosterone:cortisol ratio, and an enhancement in markers of cardiovascular and endothelial functions.

    But what is abdominal obesity and how is it connected to visceral adipose tissue and cortisol?
    Abdominal obesity is a function of the accumulation of visceral adipose tissues (VAT) and subcutaneous adipose tissue (SCAT). Accounting for up to a fifth of total fat in men, VAT is distributed in the deep cavity beneath abdominal muscles. Its location makes it very difficult to target and detonate.

    VAT has a very powerful impact on abdominal obesity. On its part, SCAT is located on top of abdominal muscles, right beneath the skin, and is consequently easier to reach and trim than VAT. VAT accumulation is known to not only be positively correlated with, but also sustains the development of, such metabolic abnormalities as hyperlipidemia, cardiovascular disorders (including endothelial dysfunction, insulin disturbances, and so on. VAT accumulation is not just a problem for obese individuals. Even lean individuals with elevated VAT accumulation are equally susceptible to the problems outlined earlier. Consequently, and as VAT adipocyte is more sensitive to lipolysis, even a modest (5-10 percent) body weight loss can preferentially produce a greater reduction in VAT deposits compared to SCAT.

    Based on the earlier discussion, this reduced concentration in the VAT depot can trigger dramatic improvements in pro-inflammatory and pro-atherogenic markers, including reductions in insulin insensitivity, improved fat oxidation, and markers of cardiovascular function.

    So, what are the key differences between VAT and SCAT, and why is reduction of VAT depots significantly more beneficial?
    1. VAT adipocytes are more sensitive to lipolysis, and produce more inflammatory cytokines such as IL-6 and plasminogen activator inhibitor-1 (PA-1). VAT supports the increased transport of glycerol and free fatty acids to the liver, leading to a stimulation of hepatic glucose production, and ultimately insulin abnormalities.
    2. VAT adipocytes have a higher GLUT-4 expression than SCAT adipocytes, leading to a higher level of insulin-triggered glucose uptake, ultimately inducing preferential triglyceride stores in VAT.
    3. VAT is strongly negatively correlated with plasma levels of total testosterone, free testosterone, and sex-hormone binding globulin levels.
    4. VAT possesses more glucocorticoid receptors than SCAT, making 11▀-HSD1 especially active in VAT. As 11▀-HSD1 activity is significantly higher in VAT adipocytes than in SCAT ones, a much higher amount of cortisol is produced in VAT, leading to further VAT accumulation, and metabolic abnormalities.


    VAT is the site of significantly more glucocorticoid receptors than SCAT, making the VAT an important center for 11▀-HSD1 activity, and thus, cortisol concentrations. So, by inhibiting the action of the 11▀-HSD1 enzyme, VAT Attack! not only reduces global cortisol action, but also cortisol concentrations in the VAT, thus inducing lipolysis and visceral fat loss (as well as SCAT fat loss), improved insulin sensitivity, and cardiovascular function.

    To note, besides inducing fat accumulation, cortisol would also initiate and sustain the systematic breakdown of muscle tissue. But, by inhibiting 11▀HSD1 activity, VAT Attack! down-regulates the conversion of cortisone to metabolically active cortisol, leading to a reduction of skeletal-muscle and adipose-tissue glucocorticoid levels. This supports effective protein synthesis and shunts fat accumulation. Furthermore, considering the existence of a positive relationship between high levels of circulating cortisol and insulin insensitivity, reductions in cortisol levels induce improvements in cellular insulin sensitivity with benefits for blood-glucose optimization, diabetic states, and fat loss.

    So, VAT Attack! is a simple-but-potent product that has a myriad of benefits including supporting the reduction in cellular visceral-adipocyte content and body weight via 11▀HSD1 inhibition; inducing favorable changes in lipid levels, thus providing considerable cardiovascular support; improving insulin sensitivity, thus providing diabetic-amelioration support; preservation of muscle mass via its anti-catabolic action induced through cortisol down-regulation; supporting the management of obese states; and so on.

    Whether you are dieting, whether you want to preserve muscle mass, or you simply wish to reduce cortisol levels to reap the associated string of benefits, whether you wish to enrich your current fat-loss stack, or whether you are in PCT (there appears to be a significant associative negative relationship between testosterone and cortisol), VAT Attack! is one non-hormonal-but-potent agent that can help you reach your goals smarter.

    Expect VAT Attack! Expect fat loss! Expect abdominal fat loss! Finally expect true (abdominal) lean mass exposure! Expect improved cardiovascular function! Expect unparalleled value for money! Get ready for a mind-blowing summer!

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    USPowders Q & A: VAT Attack!

    What is VAT Attack!?
    VAT Attack! is a specifically engineered extract from the Coffea Arabica L., plant, and an ingredient that plays a key role in the formula ReCreate. It is a natural inhibitor of 11▀HSD1 activity that down-regulates the conversion of cortisone to metabolically active cortisol, leading to a reduction of skeletal-muscle and adipose-tissue glucocorticoid levels.


    What is the purpose of VAT Attack!?
    The purpose of VAT Attack! is to potently and effectively mitigate excessive glucocorticoid levels for the purpose of regulating fat distribution, especially of the visceral adipose type, and promoting lean mass. It does so by preventing the intracellular conversion of inactive glucocorticoids (cortisone, 11-dehydrocorticosterone) to active glucocorticoids (Cortisol, corticosterone). Consequently, VAT Attack! also induces an improvement in the testosterone:cortisol ratio.


    What is Cortisol?
    Cortisol, as mentioned above, is known as a corticosteroid or glucocorticoid, and is the body’s primary glucocorticoid. While often referred to as the “stress hormone” – because of its propensity to increase during stressful periods as a reaction to mobilize energy stores – it can be altered by changes to diet and exercise as well. Cortisol’s actions are primarily controlled via three major pathways: modulation of total serum (blood) levels by the hypothalamic-pituitary-adrenal complex; by activation/inactivation in target tissues by local enzymes, or; by antagonizing the GR (glucocorticoid receptor).

    Cortisol has myriad roles in metabolically active tissues, and carries out these actions through a process known as “destructive metabolism” – i.e., ‘catabolism’. Cortisol plays an important role in the regulation of glucose homeostasis, for example, by degrading serum amino acids to raise blood glucose, as well as activating glycogenolysis in the liver – both of these actions are considered ‘catabolic’. For these and other reasons, Cortisol is highly implicated in the distribution of fatty tissue, fuel metabolism, and glucose regulation; as such, it has also been implicated in regulating body composition and the maintenance in lean mass. As a result of these implications, supplements are often sought to control Cortisol levels from reaching excess levels.


    Which one of the major pathways described above does VAT Attack! work through?
    As stated above, there are three major pathways to inhibit Cortisol: reducing serum levels through the HPA-axis (by affecting the CRH - > ACTCH pathway, for example), controlling Cortisol’s activation of the GR (by competitive binding, for example), or by inhibiting localized conversion of the inert glucocorticoid Cortisone to the active glucocorticoid Cortisol. VAT Attack! prevents the activation of the glucocorticoid Cortisol by selectively inhibiting an enzyme known as 11▀-HSD1 [1].


    Why is local inactivation preferable to systemic methods of Cortisol inhibition?
    The recent push toward selective Cortisol modulators has been made due to some of the inherent issues with systemic Cortisol regulation. Mitigating the serum production of Cortisol at the hypothalamic-pituitary-adrenal level, for example, may have unintended consequences on the greater processes of steroidogenesis, and also interfere with Cortisol’s other, vital physiological roles in the body (regulation of blood pressure, bone physiology, fuel metabolism and so on). At the receptor level, the binding of Cortisol to the GR leads to what are known as “conformational changes” to the GR, and its translocation to the cell nucleus, from the cell cytoplasm; this activation is then also responsible for Cortisol-dependent regulation of glucocorticoid receptor gene-response elements (GREs) that cause an alteration in gene expression/action; these genes, in turn, regulate Cortisol’s vital physiological functions mentioned above. The disruption of GREs, like the disruption of serum Cortisol production, can have unintended physiological and metabolic consequences. As a result of these possible consequences, the pursuit of extra-adrenal, tissue-specific methods of Cortisol regulation have been explored; 11▀-HSD1, being the predominant catalytic enzyme for GC activation, has been one such exploration.


    What is “11B-HSD1”?
    11B-HSD1 is what is known as a “local enzyme” (meaning it locally inhabits the metabolically active tissue in question – therefore, its actions are not necessarily ‘systemic’) that is, as stated, responsible for activating the inert glucocorticoid Cortisone into the active glucocorticoid Cortisol. It has two forms: an oxidase (oxidative) form and a reductase (reductive) form in metabolically active tissues. The reductive activity of 11▀-HSD1R is what we commonly refer to as “activating” Cortisol, while the oxidative role is the less-commonly known role of 11▀-HSD1, as it “inactivates” Cortisol in certain tissues. While this bi-directional enzyme predominantly (2:1 ratio) exists in the reductive capacity, and therefore inhibiting it is beneficial, its oxidative role is carried out in certain tissues such as the Testes! This essentially means that an effective 11▀-HSD1 inhibitor is known as “selective”.


    Is VAT Attack! “selective”?
    The [albeit limited] research on VAT Attack! does seem to suggest that its actions are not only selective to tissue-type [inhibition in both adipocytes and myotubes was seen] but also for isomers [1]. 11▀-HSD has both a 1 and 2 isomer, with only the 1 isomer being bi-directional. 11▀-HSD2 is exclusively oxidative in action, and its down regulation would have certain, adverse, and tissue-specific consequences.


    Is VAT Attack! hormonal?
    No, it is not. Other selective 11▀-HSD1R inhibitors are sex-hormones and/or sex-hormone derivatives in-and-of themselves, and operate by serving as direct substrates for the 11▀-HSD1R, thereby occupying the enzyme and making it unavailable to Cortisone. The nature of these inhibitors as sex-hormone (derivatives) can lead to possible suppression when used in high enough dosages. (Though suppression is not likely when used in suggested dosages.) VAT Attack!, on the other hand, is not an 11▀-HSD1R substrate or sex-hormone (derivative), but rather, works by lowering 11▀-HSD1R mRNA [1].


    Is VAT Attack! safe, and does it require support supplements?
    There is nothing in VAT Attack!'s pharmacological profile that would suggest outward adverse reactions of any kind. As a result, support supplements will not be necessary when using VAT Attack!


    Can VAT Attack! be used in P.C.T.?
    Yes. As stated, it is not a sex hormone or sex hormone derivative, and does not convert to any androgens, estrogens or progestin. Seeing as it has no hormonal action, it is perfectly suited for use in P.C.T. where Cortisol-suppression is paramount to prevent excessive destructive metabolism.


    What is an optimal dose of VAT Attack!?
    An optimal dose of VAT Attack! is 3-6 grams, depending on the purpose. In a P.C.T. environment, a maximum dose of 6 grams should be considered, due to heightened GR sensitivity to Cortisol. (Sex steroids block the GR.) For everyday use, 3 grams will suffice.


    Will I experience a “Cortisol rebound”?
    As VAT Attack!'s effects are both localized and tissue-specific, a “rebound” effect is highly unlikely. As no conformational changes of the GR, and no competitive binding to the GR occur, it is highly unlikely that an outward Cortisol rebound effect would occur through negative feedback of any kind.


    How long should I use VAT Attack!?
    8-12 weeks is the optimum time of use.


    Can I stack VAT Attack! with other Cortisol-inhibitors?
    As stated above, Cortisol plays certain necessary roles in the body. One should seek to regulate, but not decimate, its action. As such, the combination of VAT Attack! with one or more potent Cortisol-regulators may be excessive, and it is not recommended.


    Is VAT Attack! better for cutting or bulking?
    While the preservation of lean muscle tissue via localized Cortisol inhibition is where VAT Attack! will shine, it is certainly useful in a hyper caloric environment to regulate efficient fuel metabolism and regulate fat deposition.


    Can I stack VAT Attack! other USPlabs and USPowders products?
    Yes! Some useful combination's are below.


    P.C.Triple Your Gains Stack:
    This stack, consisting of PRIME, PowerFULL, and Vat Attack! is designed for a dual purpose in the P.C.T., environment: sustain the maintenance of newly acquired muscle mass, and lead to the rejuvenation of natural testosterone production. In regard to the first role, each compound “in the mix” plays a unique part. The potent and effective Cortisol mitigation of Vat Attack! alone would surely prove a formidable way to maintain newly acquired mass, based on the virtue of its ability to normalize blood glucose levels and mitigate excess Cortisol levels – avoiding the unwanted degradation of amino acids [muscle tissue] for glucose provision. One adds in both PRIME and PowerFULL, each with their own potent means of lean mass provision, and P.C.T. is complete!
    In the second role, again we see considerable synergy – specifically, the synergy between the Cortisol-mitigating properties of Vat Attack! and the natural testosterone-enhancing capacities of both of PowerFULL’s ingredients. It is well known that suppressing either Cortisol or Prolactin alone can lead to substantial increases in natural Testosterone, though through obviously different pathways – combining these effects [Cortisol inhibition of Vat Attack! and Prolactin inhibition from the L-DOPA found within PowerFULL] is sure to produce rapid rejuvenation of the H.P.G.A “post-cycle”.

    USPlabs P.C.Triple Yo' Gains Dosing Protocol:
    Training Days:
    USPlabs PRIME (PRIME 69 Protocol) = 3 capsules with food (a.m. dose), 2capsules with another meal, 2 capsules 35-45 minutes pre workout, 2 capsules with last meal of the day.
    USPlabs PowerFULL = 3 capsules 30 minutes prior to training, 2 capsules 30 minutes prior to bedtime on an empty stomach.
    USPowders VAT Attack! = 3g split over 2-3 doses per day. Typical dosing times would be Morning Cardio, Pre-Workout and Pre-Bed to correlate with typical times of cortisol release.
    One may increase daily dose by one gram each week to experiment with higher dosages, upper end being ~6g/day.

    Non-Training Days:
    USPlabs PRIME (PRIME 69 Protocol) = 2 capsules with food 3 times a day.
    USPlabs PowerFULL = 3 capsules 30 minutes prior to training, 2 capsules 30 minutes prior to bedtime on an empty stomach.
    USPowders VAT Attack! = 3g split over 2-3 doses per day. Typical dosing times would be Morning Cardio, Pre-Workout and Pre-Bed to correlate with typical times of cortisol release.
    One may increase daily dose by one gram each week to experiment with higher dosages, upper end being ~6g/day.

    Take one day off per week of PRIME and PowerFULL.


    Six Pack Vat Attack! Stack
    As you may well know, the Six Pack Stack [comprised of Anabolic Pump and ReCreate] is one of the most popular stacks on the market, for several reasons – most notably, the ability of Six Pack Stack to directly regulate fuel metabolism; specifically, the sustaining of normalized blood glucose levels, the regulation of triglyceride and fatty acid synthesis, storage, and expenditure [through both the actions of AP-dependent AMPk, and the regulation of enzymes such as glycerol-3-phosphate dehydrogenase by ReCreate], and the regulation of the body’s key hormones for catabolic fuel metabolism [epinephrine/norepinephrine and T3]. Now, imagine adding in a compound that not only assists in the maintenance of blood glucose and the improvement to Insulin sensitivity, but also contributes to regulation of lipid metabolism and lean mass maintenance! With Vat Attack! and the Six Pack Stack, one essentially regulates every major pathway of fuel metabolism.

    USPlabs Six Pack VAT Attack! Stack:
    Training and Non-Training Days:
    USPlabs Anabolic-Pump = 1 capsule, 3 times per day 20 minutes prior to carbohydrate containing meals. Prioritize your pre-workout dose.
    USPlabs Recreate = 2 capsules 30 minutes prior to breakfast, 1 capsules 30 minutes prior to training on an empty stomach.
    USPowders VAT Attack! = 3g split over 2-3 doses per day. Typical dosing times would be Morning Cardio, Pre-Workout and Pre-Bed to correlate with typical times of cortisol release.
    One may increase daily dose by one gram each week to experiment with higher dosages, upper end being ~6g/day.

    How much is it?
    Vat Attack! will be $19.99 at Nutraplanet, and this will last approximately 30 days.
    USPowders at Nutraplanet.com

    How can you stack VAT Attack! ???

    Contest coming soon!!!
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    This looks freakin awesome. Youve done it again Jacob. Ur the man
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    Quote Originally Posted by Rah22491 View Post
    This looks freakin awesome. Youve done it again Jacob. Ur the man
    Thanks for your support buddy!
    \\ USPlabs Alpha Ginger //
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    WOW, this sounds absolutely amazing. Not only controlling 11B-HSD1 selectively but in a non-hormonal way, this is truely a novel compound. I cannot wait to get me some VAT Attack.

    BTW, I don't know if I missed it in the write-up but how many grams will we get for the 30-day supply. I want to stack this with Super Cissus along with Purple Wraath and Cordygen Ultra VO2.

    I'm also intersted in this VAT Attack contest. How long before this arrives at Nutra? I apologize but I am VERY eager to get my order in, VAT Attack is the only thing I'm waiting on. Cortisol has no chance in messing up my summer cut this year. Let's do this USPlabs!
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    Quote Originally Posted by F355 View Post
    WOW, this sounds absolutely amazing. Not only controlling 11B-HSD1 selectively but in a non-hormonal way, this is truely a novel compound. I cannot wait to get me some VAT Attack.

    BTW, I don't know if I missed it in the write-up but how many grams will we get for the 30-day supply. I want to stack this with Super Cissus along with Purple Wraath and Cordygen Ultra VO2.

    I'm also intersted in this VAT Attack contest. How long before this arrives at Nutra? I apologize but I am VERY eager to get my order in, VAT Attack is the only thing I'm waiting on. Cortisol has no chance in messing up my summer cut this year. Let's do this USPlabs!
    Very exciting powder and at 3 grams a day which is recomended, the powder will last over 30 days.

    NP should have it friday on site or monday the latest.
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    good stuff, Jacob.

    USPlabs keeps putting out innovative products the science to back it.
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    Quote Originally Posted by USPLabs View Post
    Very exciting powder and at 3 grams a day which is recomended, the powder will last over 30 days.

    NP should have it friday on site or monday the latest.
    C'mon Friday or Monday. My eyes will be on Nutra. I want to be sure to get mine before they sell out. Talk about perfect timing, I should be starting my PCT right when I get this.

    Should I wait until the 3rd or 4th week of PCT to introduce VAT ATTACK? Most information on 7-oxo dhea type cort blockers recommend this kind of timing and I was wondering if it is true for this product as well.

    Thanks Jacob and all of the great USP reps for great products and great customer service!
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    hmm interesting.
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    i hate living in a super controlled country overseas... i always miss usp's awesome powders...
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    A certian monkey told me that it will be on sale at NP today.
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    Quote Originally Posted by USPLabs View Post
    A certian monkey told me that it will be on sale at NP today.
    What u say Willis??
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    Voila: VAT Attack
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    http://www.nutraplanet.com/product/u...100-grams.html

    Those NP guys are fast and this will sell as fast.
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    Is there a scoop in this?
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    Quote Originally Posted by benj851 View Post
    Is there a scoop in this?
    no sir
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    yet another great USP poduct!!! I'll be getting some of this & using it later. Right now I'm on Eviscerate & Alpha-Yohimbine.
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    huge props for the write up.

    normally i do my own research after reading a write up and decide for my self, however, i think i just got sucked in !!!!

    may have to run this as my post PCT
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    my order is in. should be v gd
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    I hope it's still in stock Monday.
    CORE NUTRITIONALS Representative

    If you have any questions feel free to email me at, tommy.day@corenutritionals.com
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    Quote Originally Posted by Steveoph View Post
    Voila: VAT Attack
    Awesome job, NutraPlanet! I did not expect it to turn up before Monday.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowdersĺ opinion as a whole.
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    Just bought it. lets see what it does!
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    Quote Originally Posted by benj851 View Post
    Just bought it. lets see what it does!
    Thank you! Let us know how things go.
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    I bought some, interested to see how this is gonna hold up compared to say 11-oxo. Isnt this sort of the same pathway 11oxo is supposed to be working?

    Also stacking with endoamp max wont be to much on the cort inhibiting will it?
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    Quote Originally Posted by 1HP View Post
    I bought some, interested to see how this is gonna hold up compared to say 11-oxo. Isnt this sort of the same pathway 11oxo is supposed to be working?
    VAT Attack! is completely non-hormonal.

    Also stacking with endoamp max wont be to much on the cort inhibiting will it?
    I would be hesitant to stack the two at full doses. If you absolutely intend to use the two together, I would recommend a full dose of VAT Attack! and half a dose of EndoAmp Max, if your main concern is visceral-adipose tissue reduction. Alternatively, you could do full EndoAmp Max and half a dose of VAT Attack!, if you are more concerned about general cortisol management, as opposed to a targeted visceral-adipose tissue focus.

    Ideally, though, I would recommend them sequentially with a break in-between.
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    Just placed my order as well this looks very promising and I'm looking forward to a little help for my summer shredding! haha... Do you guys think VAT Attack will stack with Formex?
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    Quote Originally Posted by wolverines View Post
    Just placed my order as well this looks very promising and I'm looking forward to a little help for my summer shredding! haha...
    Sounds awesome. Thanks for your support!

    you guys think VAT Attack will stack with Formex?
    Absolutely!
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    Quote Originally Posted by crazyfool405 View Post
    ...however, i think i just got sucked in !!!!
    Was that a good thing?
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    Do you have any studies showing Arabica extract lowers cortisol? I went crazy searching for evidence for my work that coffee extracts inhibit 11-b. I found that they inhibit glucose-6-phosphatase, which is effective for controlling blood sugar and thus fat loss, but nothing on cortisol control.

    http://www.svetol.com/upload/coffee-..._on_G6Pase.pdf

    What's interesting about this is people that have natural defeciencies in glucose-6-phosphatase suffer from higher cortisol levels because they body is breaking down muscle for other fuel sources. Not to say the extract does the same thing, but I wouldn't expect to lower it.

    http://emedicine.medscape.com/article/119184-overview

    I was under the impression that the (2-(4-(beta-D-Gluco-pyranosyloxy) phenyl)-5-hydroxy-6, 7-dimethoxy-4H-1 -benzopyran-4-one was actually the source of cortisol control in Recreate, because I was pretty sure it was polymethoxylated flavones, like citricoma, which is an 11-b inhibitor.

    http://www.hpingredients.com/citricoma.htm

    If you do have a study showing Arabica as an 11-b inhibitor, it would really help me out.

    Thanks
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    Quote Originally Posted by Dancebot 2000 View Post
    Do you have any studies showing Arabica extract lowers cortisol? I went crazy searching for evidence for my work that coffee extracts inhibit 11-b. I found that they inhibit glucose-6-phosphatase, which is effective for controlling blood sugar and thus fat loss, but nothing on cortisol control.

    http://www.svetol.com/upload/coffee-..._on_G6Pase.pdf

    What's interesting about this is people that have natural defeciencies in glucose-6-phosphatase suffer from higher cortisol levels because they body is breaking down muscle for other fuel sources. Not to say the extract does the same thing, but I wouldn't expect to lower it.

    http://emedicine.medscape.com/article/119184-overview

    I was under the impression that the (2-(4-(beta-D-Gluco-pyranosyloxy) phenyl)-5-hydroxy-6, 7-dimethoxy-4H-1 -benzopyran-4-one was actually the source of cortisol control in Recreate, because I was pretty sure it was polymethoxylated flavones, like citricoma, which is an 11-b inhibitor.

    http://www.hpingredients.com/citricoma.htm

    If you do have a study showing Arabica as an 11-b inhibitor, it would really help me out.

    Thanks
    Well we have access to research not common to the google or pubmed search.

    [6] Walker BR. Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning. Proc Nutr Soc. 2007 Feb;66(1):1-8
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    Quote Originally Posted by USPLabs View Post
    Well we have access to research not common to the google or pubmed search.

    [6] Walker BR. Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning. Proc Nutr Soc. 2007 Feb;66(1):1-8
    Wicked. Thanks boss.

    Edit: maybe you have access to part of it I don't, but from what I see that study had nothing to do with Coffee extracts.
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    Quote Originally Posted by Dancebot 2000 View Post
    Wicked. Thanks boss.

    Edit: maybe you have access to part of it I don't, but from what I see that study had nothing to do with Coffee extracts.
    [4] Atanasov AG, Dzyakanchuk AA, Schweizer RA, et al. Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of coffee? FEBS Lett. 2006 Jul 24;580(17):4081-5.

    oops
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    haha. Thanks, that's much better.
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    Ordered mine yesterday!!! Does anyone know the best way to take this? Will it dissolve well in juice? In the past I have had some powders that haven't dissolved well and ended up just coating the inside of the glass.
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    11▀-HSD has other actions in the body than just making cortisol from cortisone.
    by lowering 11▀-HSD wont u be lowering test ability to convert to other anabolic hormones because of a lack of 11▀-HSD?
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    Quote Originally Posted by alwaysgaining View Post
    11▀-HSD has other actions in the body than just making cortisol from cortisone.
    by lowering 11▀-HSD wont u be lowering test ability to convert to other anabolic hormones because of a lack of 11▀-HSD?
    We are talking about the specific modulation of 11▀-HSD1, not 11▀-HSD2, and not both isoforms. Cortisol, by the way, inhibits steroidogenic enzymes and key proteins involved in testosterone biosynthesis in Leydig cells. However, 11▀-HSD2 is crucial for the reduction of intracellular cortisol levels in Leydig cells, such that 11▀-HSD2 inhibition would induce undesirable effects on testosterone synthesis. As it turns out, our extract does not disrupt testosterone synthesis, as it selectively inhibits 11▀-HSD1, not 11▀-HSD2.
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    Interesting review on 11B-HSD1 inhibition and the metabolic syndrome PMID: 18230901
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    Quote Originally Posted by Steveoph View Post
    Interesting review on 11B-HSD1 inhibition and the metabolic syndrome PMID: 18230901
    So if I read the study right, noting that it is on rats not on humans, then for obese people on high fat diets, inhibiting the 11beta -HSD1 would be benefical as it was actually proven to reduce fat while the rodents were on the high fat diet.

    Doesn't this study confirm what Jacob and Ike have been saying, it helps destroy visceral fat, where the most 11b-hsd1 enzyme is located?

    even moreso, the study says that inhibiting the 11beta -HSD1 enzyme in people who are naturally obese helps them overcome the naturally or dare I say it genetic fat... making a product that inhibits 11beta -HSD1 even better for endomorphs.

    my question after reading this is whether VAT ATTACK would work better on a ckd type diet or a regular 40/40/20 macro diet? since the study notes that inhibiting the enzyme worked dramatically for rats and hopefully people on a high fat diet, like ckd.

    What do you think?
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    [QUOTE=strategicmove;1992518]We are talking about the specific modulation of 11▀-HSD1, not 11▀-HSD2, and not both isoforms. Cortisol, by the way, inhibits steroidogenic enzymes and key proteins involved in testosterone biosynthesis in Leydig cells. However, 11▀-HSD2 is crucial for the reduction of intracellular cortisol levels in Leydig cells, such that 11▀-HSD2 inhibition would induce undesirable effects on testosterone synthesis. As it turns out, our extract does not disrupt testosterone synthesis, as it selectively inhibits 11▀-HSD1, not 11▀-HSD2.[/QUOTE]

    i just wanted some one to say that so ppl dont get confuzed
  

  
 

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